Gene Information

Name : TBHG_02688 (TBHG_02688)
Accession : YP_002159713.1
Strain : Mycobacterium tuberculosis Haarlem
Genome accession: NC_022350
Putative virulence/resistance : Unknown
Product : type I restriction/modification system DNA methylase HsdM
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 3062521 - 3064143 bp
Length : 1623 bp
Strand : -
Note : -

DNA sequence :
ATGCCGCCCAGGAAGAAGCAGGCGCCGCAGGCGCCGTCGACGATGAAGGAGCTCAAAGACACGCTCTGGAAGGCCGCCGA
CAAGCTGCGCGGGTCGCTGTCGGCCAGCCAATACAAGGACGTGATCCTCGGCCTGGTGTTCCTTAAGTACGTGTCCGACG
CGTATGACGAACGGCGCGAGGCAATCCGTGCCGAGTTGGCGGCCGAAGGAATGGAGGAGTCTCAGATAGAAGACCTGATC
GACGATCCCGAGCAGTACCAGGGTTACGGCGTATTCGTCGTGCCGGTGAGTGCGCGCTGGAAGTTCTTGGCAGAGAACAC
AAAAGGCAAGCCAGCCGTTGGTGGTGAGCCGGCGAAGAACATCGGTCAGCTGATCGACGAGGCGATGGACGCGGTAATGA
AGGCCAATCCAACACTCGGTGGGACGCTGCCGAGGCTGTATAACAAGGACAACATCGACCAGCGCCGGCTCGGTGAGCTG
ATCGACCTATTTAACAGTGCGCGCTTCAGCCGGCAGGGCGAGCACCGCGCCCGGGATCTGATGGGTGAGGTCTACGAATA
CTTCCTCGGCAATTTCGCTCGCGCGGAAGGGAAGCGGGGTGGCGAGTTCTTTACCCCGCCCAGCGTGGTCAAGGTGATCG
TGGAGGTGCTGGAGCCGTCGAGTGGGCGGGTGTATGACCCGTGCTGCGGTTCCGGAGGCATGTTTGTGCAGACCGAGAAG
TTCATCTACGAACACGACGGCGATCCGAAGGATGTCTCGATCTATGGCCAGGAAAGCATTGAGGAGACCTGGCGGATGGC
GAAGATGAACCTCGCCATCCACGGCATCGACAACAAGGGGCTCGGCGCCCGATGGAGTGATACCTTCGCCCGCGACCAGC
ACCCGGACGTGCAGATGGACTACGTGATGGCCAATCCGCCGTTCAACATCAAAGACTGGGCCCGCAACGAGGAAGACCCA
CGCTGGCGCTTCGGTGTTCCGCCCGCCAATAACGCCAACTACGCATGGATTCAGCACATCCTGTACAAGTTGGCGCCGGG
AGGTCGGGCGGGCGTGGTGATGGCCAACGGGTCGATGTCGTCGAACTCCAACGGCGAGGGGGATATTCGCGCGCAGATCG
TGGAGGCGGATTTGGTTTCCTGCATGGTCGCGTTACCCACCCAGCTGTTCCGCAGCACCGGAATCCCGGTGTGCCTGTGG
TTTTTCGCCAAAGACAAGGCGGCAGGTAAGCAAGGGTCTATCGACCGGTGCGGGCAGGTGCTGTTCATCGACGCTCGTGA
ACTGGGCGACCTAGTGGACCGGGCCGAGCGGGCGCTGACCAACGAGGAGATCGTCCGCATCGGGGATACCTTCCACGCGT
GGCGCGGGTCGAAGTCGGCTGCCGTCAAAGGGATTATGTACGAGGATGTTCCGGGGTTCTGTAAGTCGGCGACGTTGGCG
GAGATCAAGGCGACCGACTATGCGCTCACGCCGGGGCGGTATGTGGGTACGCCCGCGGTCGAGGACGACGGAGAGCCGAT
CGACGAGAAGATGGCCCGGTTGTCGAAGGCGTTGCTGGAGGCGTTCGATGAGTCGGCGCGGCTGGAAAGGGTCGTGCGGG
AGCAACTGGGGCGGCTTAGATGA

Protein sequence :
MPPRKKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLVFLKYVSDAYDERREAIRAELAAEGMEESQIEDLI
DDPEQYQGYGVFVVPVSARWKFLAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGGTLPRLYNKDNIDQRRLGEL
IDLFNSARFSRQGEHRARDLMGEVYEYFLGNFARAEGKRGGEFFTPPSVVKVIVEVLEPSSGRVYDPCCGSGGMFVQTEK
FIYEHDGDPKDVSIYGQESIEETWRMAKMNLAIHGIDNKGLGARWSDTFARDQHPDVQMDYVMANPPFNIKDWARNEEDP
RWRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRAQIVEADLVSCMVALPTQLFRSTGIPVCLW
FFAKDKAAGKQGSIDRCGQVLFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYEDVPGFCKSATLA
EIKATDYALTPGRYVGTPAVEDDGEPIDEKMARLSKALLEAFDESARLERVVREQLGRLR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 6e-123 49
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 3e-123 49
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 3e-122 48
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 7e-108 45