Gene Information

Name : entE (M892_06050)
Accession : YP_008525986.1
Strain :
Genome accession: NC_022269
Putative virulence/resistance : Virulence
Product : enterobactin synthase subunit E
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.7.58
Position : 1312911 - 1314530 bp
Length : 1620 bp
Strand : -
Note : bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate;

DNA sequence : 
ATGAGTCACGAGTCTATGCAAGCATCCGGTTTTACCCCATGGCCAGAAGCGCGAGCAGAACAATATCGCCAAGCTGGTTA
CTGGACAGATCAAACGATCCCACAAATGTTACAAGCCAGCGCTATTCGACTGCCACAGCAATTGGCATTGGTAGATGGCG
AGCGCGAGTGGACGTATCAATCTTTGGCGCAACAGGTCGACCAACTGGCGGCAGGTTTCCAAACCAAGCTGAGTCTCAAA
CCAGGAGACAAAGCGGTGTTGCATCTACCGAACATTGGGGAGTTTTATCTTAGCCTTTTCGCTCTACTCAAAATTGGCGT
GCAGCCCGTACTGTCTTTGCCAGCGCACCGTTATTCGGAGATTCGATACTTTTGTCATTTTACCGAGGCAAAAGTATTAA
TTACTGCACCGCAGCGAGGTGTGAACACGGCTGATATCGCGCAGCAAGTTGCGGCTGAATTGCCGAGTCTTACCAGCATT
GTTTGGGCGGGTGAAGTGAGCGAAATGCCTACTGGTAGCCTAACTCTCGATAGTCTTTATTTAAACGATGCCGAACTGCA
TGAAGAACAGGGAGAGGGCTTCGCGTTCTTCCAACTTTCTGGTGGAACTACGGGCACGCCAAAACTGATCCCGCGCACTC
ATAGCGACTATCTCTATAGCGTTCGTGCCAGCAATGAAGTTTGCCAGTTCTCAGATCGAACTCGTTACATTTGTGTGTTG
CCTGCGGCGCATAACTTTCCGCTTAGTTCGCCTGGTGCATTAGGCTGTTTTATGGCTGGTGGCACCGTGGTGTTAACACC
AGACGCCAGCCCTCAGACGGCGTTTTCTTTGATTGAGAAATACCAAATTACCGTGGCGGCTTTGGTTCCGCCATTAGCAC
TCTTATGGCTGGATGAAGCAGCGCGAACAGAACATGACATTACTTCCCTTGAAGTGCTGCAAGTGGGTGGTGCTCGTTTT
AGTGAAGAAGCCGCAAAGCGAGTACGACCAGAGTTGGGCTGTACCTTGCAGCAGGTGTTCGGCATGGCAGAGGGGCTCGT
AAACTACACCCGTTTGGATGACCCCGAGTCTGAAATCATTTCTACCCAAGGTCGGCCGATGTCGTCTGCGGACGAGTTGT
TGGTTCTTGATGAAATGGGCAACCCCGTTGAGCAAGGAACAGAGGGGATTTTGTTCGTGCGTGGCCCTTACACTATTCAA
GGTTACTACCGTGCGCCAGAGCATAATCAGCGTTCTTTTACTCAGCAAGGGTACTACCGCACGGGCGATATTGTCGTTTT
GACCGAAGCGGGCAACTTACAGGTGGTAGGGCGCGATAAAGATCAGATCAACCGTGGTGGAGAGAAAATCGCTGCGGAGG
AGGTCGAGAACCATCTGCTTGCCCATGACTCGGTGCACGATGCTGCCGTAATTGCCATTCCGGATGACTACTTAGGTGAG
CGCAGTTGCGCAGCTTTGGTTTGCCCAGAACAGAACCCTAGAGTGATTGAAATAAAACGCTTTTTAAGAGATCGCGGCTT
AGCGGACTTCAAGATCCCTGATCGTGTTATTTTTGTTGATGTACTGCCGAAAACTCCCGTCGGAAAAATAAATAAAAACA
AGCTATTAGAACTCGTTTAA

Protein sequence : 
MSHESMQASGFTPWPEARAEQYRQAGYWTDQTIPQMLQASAIRLPQQLALVDGEREWTYQSLAQQVDQLAAGFQTKLSLK
PGDKAVLHLPNIGEFYLSLFALLKIGVQPVLSLPAHRYSEIRYFCHFTEAKVLITAPQRGVNTADIAQQVAAELPSLTSI
VWAGEVSEMPTGSLTLDSLYLNDAELHEEQGEGFAFFQLSGGTTGTPKLIPRTHSDYLYSVRASNEVCQFSDRTRYICVL
PAAHNFPLSSPGALGCFMAGGTVVLTPDASPQTAFSLIEKYQITVAALVPPLALLWLDEAARTEHDITSLEVLQVGGARF
SEEAAKRVRPELGCTLQQVFGMAEGLVNYTRLDDPESEIISTQGRPMSSADELLVLDEMGNPVEQGTEGILFVRGPYTIQ
GYYRAPEHNQRSFTQQGYYRTGDIVVLTEAGNLQVVGRDKDQINRGGEKIAAEEVENHLLAHDSVHDAAVIAIPDDYLGE
RSCAALVCPEQNPRVIEIKRFLRDRGLADFKIPDRVIFVDVLPKTPVGKINKNKLLELV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 5e-93 46
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-92 46
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-92 46
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-92 46
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-92 46
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-92 46
ybtE CAA21394.1 - Virulence HPI Protein 1e-92 46
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-93 46
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 9e-93 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE YP_008525986.1 enterobactin synthase subunit E VFG0168 Protein 5e-113 50
entE YP_008525986.1 enterobactin synthase subunit E VFG0932 Protein 2e-113 48
entE YP_008525986.1 enterobactin synthase subunit E VFG1817 Protein 1e-95 43