Gene Information

Name : M493_13170 (M493_13170)
Accession : REF_PRJNA208285:M493
Strain : Geobacillus sp. JF8
Genome accession: NC_022080
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 2447028 - 2448161 bp
Length : 1134 bp
Strand : -
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: GeneMarkS+.

DNA sequence :
ACGTTCGTCGACACAAGCGATATCGCTAACATTGAAGCGCATATTCGCCCGAACACGAAGGCGATTTACGTTGAAACGCC
GACGAATCCGCTTTTGAAAATCACCGATTTGCAGGCGGCGGCCGCCGTTGCCCGGGCGCGCGGGCTGCTGGTGATCGTTG
ATAACACGTTTTCGACGCCGTATTTTCAAACGCCGCTTGAACTTGGTGCGGATATCGTCATCCATAGTGCGACGAAATAT
TTAGGCGGCCATAGCGATGTCGTCGCCGGACTGGCTGTCGTCCGCACCGCGGAACTCGCTGAACGGCTCCATTTCGTGCA
AAACTCGACCGGCGGCGTGCTCGGCCCGCAAGATTCGTGGCTGTTGATGCGTGGGATGAAAACGCTCGGCGTACGAATGG
AAGAACATGAACAAAATGCGCGCGCCATTGCCGCCTTTTTGTCAGAACATCCGGCGGTCACCCGCGTCTATTACCCCGGG
CTTCCGGAGCACCCGAACCACGAGTTGGCCAAGCGACAAATGCGCGGATTTGGCGGTATGATTTCGTTTGACGTCGGCAG
CCTTGAACGGGCGGAAACGGTGCTTTCCCGCGTCCGCTATTTTACGCTTGCTGAAAGCTTAGGAGCGGTTGAAAGCTTAA
TTTCGCTGCCGGGGAAAATGACGCACGCCTCGATTCCGAAAGAGCGGCGCGAACAGCTCGGCATTACGGATGGGCTCATC
CGTCTATCGGTCGGCCTCGAAGACGTCAACGATCTGCTTGACGATTTGGCGCAGGCGCTTGGCTGAAATTGCCGCTCCCT
TCTCCCCTTCTTGTTATGGTACAGTGGGAAGGAGGAGGGATCGGCGATGAACAAGGAGCAACGAAACGACTGGCGCGCGA
AGGCAGGCGATTTTAAGACATACAGCCTCGTCTTGTTCGCGCTTGGTGCGTTTTTCTATTTAGGTACGATCATCCCGGGG
GCGCTTGAGGCGGCAAAAAAACCAGTTGCTTTGCTGGCAGTTGGCGGCTGTTTTGCCGCTGCCTTGTATTGTTCGCAGCG
TTCCGCCGCTTACGCCCGCCGGCTTGAAGAAGAGGAGAACTCGTTAAAATAGTAGCAGCCTGCCTTTTGATTCAAAAGGC
GGGCTTTTTGTTTC

Protein sequence :
MRRKTMLIHGGIPGDPHTGAVSVPIYQVSTYKQEEVGKHKGFEYSRTGNPTRAALEKLIADLEGGEAGFAFASGMAAITA
VMMLFQSGDHIVLTDDVYGGTYRVMANVLNRFGLEATFVDTSDIANIEAHIRPNTKAIYVETPTNPLLKITDLQAAAAVA
RARGLLVIVDNTFSTPYFQTPLELGADIVIHSATKYLGGHSDVVAGLAVVRTAELAERLHFVQNSTGGVLGPQDSWLLMR
GMKTLGVRMEEHEQNARAIAAFLSEHPAVTRVYYPGLPEHPNHELAKRQMRGFGGMISFDVGSLERAETVLSRVRYFTLA
ESLGAVESLISLPGKMTHASIPKERREQLGITDGLIRLSVGLEDVNDLLDDLAQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-98 57
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-100 57
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-74 46

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
M493_13170 REF_PRJNA208285:M493 cystathionine beta-lyase BAC0207 Protein 4e-63 45