Gene Information

Name : aadK (RBAU_0707)
Accession : YP_008411710.1
Strain : Bacillus amyloliquefaciens UCMB-5033
Genome accession: NC_022075
Putative virulence/resistance : Resistance
Product : aminoglycoside 6-adenylyltransferase
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.7.-
Position : 748788 - 749657 bp
Length : 870 bp
Strand : +
Note : Evidence 2a:Function of homologous gene experimentally demonstrated in an other organism; PubMedId:2550327, 9308178, 9384377; Product type e:enzyme

DNA sequence :
GTGAGAAGTGAAGGCGAAATGATGAAATTGATTCTTGATATTGCGATGAAGGACGAGAGAATCCGTCTTGTCACTTTAGA
GGGATCAAGAACCAATAAAAATGTACCGAGAGACAAATTTCAAGACTATGATATTTCTTATTTTGTGACCGATATGGACT
CTTTCACATCTGACGAAAGCTGGCTGGATCAGTTTGGCGAAAGAATGATGATGCAAAAACCTGAAGATATGGAACTTTTC
CCTCCGGAACTCGGAGACTGGTTCTCCTATCTAATGCTTTTTAAAGATCATCATAAAATCGACTTAACTTTGATCCCTCT
GAGTCAAACAGAGGCTTATTTTACACAGAGTGATGGTTTGGCGGAAATATTATTAGACAAGGATGACCGAATCAACAGTA
AGATTATTGCGAGTGATGAACAATATCATATAAAGAAACCGACCCCCAGAGAGTTTGATGATTGCTGCAATGAATTTTGG
ATGGTTTCAACCTATGTTATTAAAGGATTAATGCGTAAAGAAATACTGTTTGCGCTGGATCATATGAATGACATTTTAAG
GCCTAATGTTTTGCGTATGATTGCGTGGAATATCGGGATAGAGAATCAGTTTTCATTAAGTGTAGGGAAGAATTATAAGT
ATATTCAACATTACATGAATGCGAAAGATTGGGAAATTCTGCTGAATACTTATGTCGGCAATACTTATGAAGGCGTGTGG
AAGGCATTGTTTGACTGCCAGGGTCTCTTTAGAGCATATTCAAAGTCAGTGGCTGTTTTATTGAGATATGAATATCCTGA
ATATGATCAACAAATTACGGAATATACATTGAAACATTATCAGCGCTTTCAATCAGATTTTTCATTATGA

Protein sequence :
MRSEGEMMKLILDIAMKDERIRLVTLEGSRTNKNVPRDKFQDYDISYFVTDMDSFTSDESWLDQFGERMMMQKPEDMELF
PPELGDWFSYLMLFKDHHKIDLTLIPLSQTEAYFTQSDGLAEILLDKDDRINSKIIASDEQYHIKKPTPREFDDCCNEFW
MVSTYVIKGLMRKEILFALDHMNDILRPNVLRMIAWNIGIENQFSLSVGKNYKYIQHYMNAKDWEILLNTYVGNTYEGVW
KALFDCQGLFRAYSKSVAVLLRYEYPEYDQQITEYTLKHYQRFQSDFSL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSU05_0957 YP_001198323.1 aminoglycoside 6-adenylyltansferase Not tested 89K Protein 2e-86 59
SSU98_0964 YP_001200522.1 aminoglycoside 6-adenylyltansferase Not tested 89K Protein 2e-86 59
aadE YP_003446812.1 streptomycin aminoglycoside 6-adenyltransferase Not tested The aminoglycoside resistance gene cluster Protein 1e-84 58
aadE AFJ97257.1 streptomycin aminoglycoside 6-adenyltransferase Not tested Not named Protein 2e-59 57
aadE AFJ97264.1 putative adenyltransferase Not tested Not named Protein 2e-77 56
SAKOR_00397 YP_008490581.1 Aminoglycoside 6-adenylyltransferase Not tested vSa¥á Protein 5e-42 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
aadK YP_008411710.1 aminoglycoside 6-adenylyltransferase NC_006663.1.orf0.gen Protein 2e-78 59
aadK YP_008411710.1 aminoglycoside 6-adenylyltransferase FN594949.1.gene25.p0 Protein 9e-76 54
aadK YP_008411710.1 aminoglycoside 6-adenylyltransferase AJ489618.1.orf2.gene Protein 4e-60 53