Gene Information

Name : tpx (N220_13275)
Accession : YP_008340054.1
Strain : Mannheimia haemolytica USMARC_2286
Genome accession: NC_021883
Putative virulence/resistance : Virulence
Product : lipid hydroperoxide peroxidase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2522141 - 2522638 bp
Length : 498 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.

DNA sequence : 
ATGAGTAAAGTGACTTTAGCAGGAAGCCCGATTGATGTTGCAGGCACATTTCCACAAAAAGGCGATGTGGTTGCCGATTT
TACCTTAGTCAACAGTGATTTAAGTGATGTTTCGCTTTCCGATTTTGATGGCAAACGCAAAGTGTTAAATATTTTCCCAA
GTATTGACACCGGCATTTGTGCCACTTCTGTGCGTGTGTTTAATCAAAAAGCGGCTGATGTAGCGAATACGGTTGTCCTT
TGTATTTCAGCGGATTTACCTTTTGCCCAAGCACGTTTCTGTGGAGCAGAAGGAATTGAAAATGCCAAAGTATTATCCAG
TTTCCGTCATCGTGATTTACACAACAAACTGGGGGTAGATATTATTTCAGGTCCGTTGGCAGGCTTAACTTCACGTTCAG
TAATTGTGTTAGATGAAAACAACAAGGTATTACACAGCGAATTAGTGCCGGAAATTAAACAAGAGCCGGATTATGAGGCG
GCGTTAGCGGTATTATAA

Protein sequence : 
MSKVTLAGSPIDVAGTFPQKGDVVADFTLVNSDLSDVSLSDFDGKRKVLNIFPSIDTGICATSVRVFNQKAADVANTVVL
CISADLPFAQARFCGAEGIENAKVLSSFRHRDLHNKLGVDIISGPLAGLTSRSVIVLDENNKVLHSELVPEIKQEPDYEA
ALAVL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 8e-29 46
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 5e-29 46
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 6e-29 45
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 4e-29 45

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_008340054.1 lipid hydroperoxide peroxidase VFG0087 Protein 2e-29 46