Gene Information

Name : CFSAN002050_20725 (CFSAN002050_20725)
Accession : YP_008262016.1
Strain : Salmonella enterica CFSAN002050
Genome accession: NC_021818
Putative virulence/resistance : Virulence
Product : pathogenicity island 1 effector protein SipB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 3959968 - 3961749 bp
Length : 1782 bp
Strand : -
Note : cell invasion protein B; required for entry of the bacteria into the host cell; induces apoptosis in macrophages; Derived by automated computational analysis using gene prediction method: Protein Homology.

DNA sequence :
ATGGTAAATGACGCAAGTAGCATTAGCCGTAGCGGATATACCCAAAATCCGCGCCTCGCTGAGGCGGCTTTTGAAGGCGT
TCGTAAGAACACGGACTTTTTAAAAGCGGCGGATAAAGCTTTTAAAGATGTGGTGGCAACGAAAGCGGGCGACCTTAAAG
CCGGAACAAAGTCCGGCGAGAGCGCTATTAATACGGTGGGTCTAAAGCCGCCTACGGACGCCGCCCGGGAAAAACTCTCC
AGCGAAGGGCAATTGACATTACTGCTTGGCAAGTTAATGACGCTACTGGGCGATGTTTCGCTGTCTCAACTGGAGTCTCG
TCTGGCGGTATGGCAGGCGATGATTGAGTCACAAAAAGAGATGGGGATTCAGGTATCGAAAGAATTCCAGACGGCTCTGG
GAGAGGCTCAGGAGGCGACGGATCTCTATGAAGCCAGTATCAAAAAGACGGATACCGCCAAGAGTGTTTATGACGCTGCG
GCCAAAAAACTGACGCAGGCGCAAAATAAATTGCAATCGCTGGACCCGGCTGACCCCGGCTATGCACAAGCTGAAGCCGC
GGTAGAACAGGCAGGAAAAGAAGCGACAGAGGCGAAAGAGGCATTAGATAAGGCCACGGATGCGGCGGTTAAAGCAGGCA
CAGACGCCAAAGCGAAAGCCGAGAAAGCGGATAACATTCTGACTAAATTCCAGGGAACGGCTAATGCCGCCTCTCAGAAT
CAGGTTTCCCAGGGTGAGCAGGATAATCTGTCAAATGTCGCCCGCCTCACTATGCTCATGGCCATGTTTATTGAGATTGT
GGGCAAAAATACGGAAGAAAGCCTGCAAAACGATCTTGCGCTTTTCAACGCCTTGCAGGAAGGGCGTCAGGCGGAGATGG
AAAAGAAATCGGCTGAATTCCAGGAAGAGACGCGCAAAGCCGAGGAAACGAACCGCATTATGGGATGTATCGGGAAAGTC
CTCGGCGCGCTGCTAACCATTGTCAGCGTTGTGGCCGCTGTTTTTACCGGTGGGGCGAGTCTGGCGCTGGCTGCGGTGGG
ACTTGCGGTAATGGTGGCCGATGAAATTGTGAAGGCGGCGACGGGGGTGTCGTTTATTCAGCAGGCGCTAAACCCGATTA
TGGAGCATGTGCTGAAGCCGTTAATGGAGCTGATTGGCAAGGCGATTACCAAAGCGCTGGAAGGATTAGGCGTCGATAAG
AAAACGGCGGAGATGGCCGGTAGCATTGTTGGCGCGATTGTTGCCGCTATTGCGATGGTCGCGGTCATTGTGGTGGTCGC
AGTTGTCGGGAAAGGCGCGGCGGCGAAACTGGGTAACGCGCTGAGCAAAATGATGGGCGAAACGATTAAGAAGTTGGTGC
CTAACGTGCTGAAACAGTTGGCGCAAAACGGCAGCAAACTCTTTACCCAGGGGATGCAACGTATTACTAGCGGTCTGGGT
AATGTGGGTAGCAAGATGGGCCTGCAAACGAATGCCTTAAGTAAAGAGCTGGTAGGTAATACCCTAAATAAAGTGGCGTT
GGGCATGGAAGTCACGAATACCGCAGCCCAGTCAGCCGGTGGTGTTGCCGAGGGGGTATTTATTAAAAATGCCAGTGAGG
CGCTTGCTGATTTTATGCTCGCCCGTTTTGCCATGGATCAAATTCAGCAGTGGCTTAAACAATCCGTAGAAATATTTGGT
GAAAACCAGAAGGTAACGGCGGAACTGCAAAAAGCCATGTCTTCTGCGGTACAGCAAAATGCGGATGCTTCGCGTTTTAT
TCTGCGCCAGAGTCGCGCATAA

Protein sequence :
MVNDASSISRSGYTQNPRLAEAAFEGVRKNTDFLKAADKAFKDVVATKAGDLKAGTKSGESAINTVGLKPPTDAAREKLS
SEGQLTLLLGKLMTLLGDVSLSQLESRLAVWQAMIESQKEMGIQVSKEFQTALGEAQEATDLYEASIKKTDTAKSVYDAA
AKKLTQAQNKLQSLDPADPGYAQAEAAVEQAGKEATEAKEALDKATDAAVKAGTDAKAKAEKADNILTKFQGTANAASQN
QVSQGEQDNLSNVARLTMLMAMFIEIVGKNTEESLQNDLALFNALQEGRQAEMEKKSAEFQEETRKAEETNRIMGCIGKV
LGALLTIVSVVAAVFTGGASLALAAVGLAVMVADEIVKAATGVSFIQQALNPIMEHVLKPLMELIGKAITKALEGLGVDK
KTAEMAGSIVGAIVAAIAMVAVIVVVAVVGKGAAAKLGNALSKMMGETIKKLVPNVLKQLAQNGSKLFTQGMQRITSGLG
NVGSKMGLQTNALSKELVGNTLNKVALGMEVTNTAAQSAGGVAEGVFIKNASEALADFMLARFAMDQIQQWLKQSVEIFG
ENQKVTAELQKAMSSAVQQNADASRFILRQSRA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
sipB YP_217804.1 cell invasion protein Virulence SPI-1 Protein 0.0 99
sipB NP_461806.1 translocation machinery component Virulence SPI-1 Protein 0.0 99
sipB NP_457279.1 pathogenicity island 1 effector protein Virulence SPI-1 Protein 0.0 99
sipB NP_806488.1 pathogenicity island 1 effector protein Virulence SPI-1 Protein 0.0 99

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CFSAN002050_20725 YP_008262016.1 pathogenicity island 1 effector protein SipB VFG0546 Protein 0.0 99
CFSAN002050_20725 YP_008262016.1 pathogenicity island 1 effector protein SipB VFG0987 Protein 6e-70 43