Gene Information

Name : guaA (F382_01870)
Accession : YP_008233258.1
Strain : Mannheimia haemolytica D153
Genome accession: NC_021743
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : -
COG ID : -
EC number : 6.3.5.2
Position : 364024 - 365595 bp
Length : 1572 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; Derived by automated computational analysis using gene prediction method: GeneMarkS+.

DNA sequence :
ATGACAAACATCCACCACCACAAAATTTTAATTTTAGACTTCGGTTCACAATATACTCAGCTTATCGCACGCCGTGTGCG
GGAGATTGGGGTTTACTGCGAGCTTTGGGCTTGGGACGTAACGGAAGAGCAGATCCGTGAATTTAACCCAACGGGGATTA
TTCTTTCAGGAGGTCCTGAAAGCACCACTGAGGAAAACAGCCCACGAGCGCCGGAGTATGTGTTTAACGCTGGTCTGCCA
GTGCTGGGCATTTGCTACGGAATGCAGACAATGGCGATGCAGTTGGGCGGTTTAACCGAAACGTCCGACCACCGTGAATT
TGGCTATGCCTCGGTGGCTCTCAAATCTGCCGATCAACTTTTTGCAAATTTAAACGATGATTTGACCGCTTGCGAGCCAA
AATTGGACGTGTGGATGAGTCACGGCGACAAAGTCACCAAATTACCACCGCACTTTACCATCACAGGCGTTACCCCAACC
TGCCCGATTGCCGCGATGTCGGACGAAAGCCGCCGTTTCTATGGCGTGCAGTTCCACCCCGAAGTGACCCACACCAAACA
AGGCTTGGCGTTGCTGAAAAACTTCGTGGTCGGCATTTGCGGCTGTGAAACGAACTGGACGGCAGAAAACATCATTGAAG
ATGCGGTGAAACGCATTCGTGAGCAAGTGGGCGATGACGAGGTGATTTTAGGTTTGTCGGGCGGGGTGGATTCCTCCGTC
ACCGCCTTGCTATTACATCGTGCTATCGGTAAAAACCTGCACTGCGTATTTGTGGATAACGGCTTGCTCCGCTTGAACGA
AGGCGATCAAGTCATGGAAATGTTCGGCAACAAATTCGGTTTGAACATTGTGCGAGTGAATGCCGAAGACCGTTTCTTAG
AAGCGTTAAAAGGCTTAGACGAACCGGAAGCTAAACGCAAAACCATTGGTAAAGTGTTTGTGGACGTGTTTGATGACGAA
AGCAAAAAACTTAGCTCGGTCAAATGGCTTGCACAAGGCACGATCTACCCTGATGTGATTGAATCCGCCGCCAGCAAAAC
CGGCAAAGCCCACGTGATTAAATCACACCATAACGTTGGCGGCTTGCCGGATTATATGAAGCTCGGCTTAGTCGAACCGT
TGCGTGAATTGTTTAAAGACGAAGTGCGCAAAATCGGCTTGGCACTCGGCTTACCGGCTGAAATGCTCAACCGCCACCCG
TTCCCCGGCCCGGGCTTAGGCGTGCGTGTGCTGGGCGAAATCAAAAAAGAGTACTGCGATTTACTGCGTAAAGCCGATGC
GATCTTCATCGAAGAACTGCACAAAGCCGGCTGGTACTACAAAGTCAGCCAAGCTTTCACGGTATTCTTGCCGGTGAAAT
CGGTGGGCGTAATGGGCGATGGACGCAAATATGACTGGGTCGTCAGCCTGCGTGCGGTGGAAACCATCGACTTTATGACC
GCTCACTGGGCGCACTTGCCGTATGATCTATTAGGCAAAATCTCCAACCGCATTATTAACGAAGTGAACGGTATTTCCCG
TGTGGTGTATGACGTGAGCGGAAAACCACCGGCAACCATTGAGTGGGAATAA

Protein sequence :
MTNIHHHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEEQIREFNPTGIILSGGPESTTEENSPRAPEYVFNAGLP
VLGICYGMQTMAMQLGGLTETSDHREFGYASVALKSADQLFANLNDDLTACEPKLDVWMSHGDKVTKLPPHFTITGVTPT
CPIAAMSDESRRFYGVQFHPEVTHTKQGLALLKNFVVGICGCETNWTAENIIEDAVKRIREQVGDDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEGDQVMEMFGNKFGLNIVRVNAEDRFLEALKGLDEPEAKRKTIGKVFVDVFDDE
SKKLSSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLLRKADAIFIEELHKAGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
AHWAHLPYDLLGKISNRIINEVNGISRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-130 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-130 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-130 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-110 48