Gene Information

Name : M943_02375 (M943_02375)
Accession : YP_008224548.1
Strain : Mycobacterium tuberculosis EAI5
Genome accession: NC_021740
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 549686 - 551206 bp
Length : 1521 bp
Strand : +
Note : catalyzes the oxidation of acetaldehyde, benzaldehyde, propionaldehyde and other aldehydes; Derived by automated computational analysis using gene prediction method: Protein Homology.

DNA sequence :
ATGACTGTCTTTTCCCGTCCCGGTTCCGCCGGGGCGCTGATGTCCTATGAATCCCGGAAAAACTTCATCGGGGGCCAGTG
GGTCGCGCCGGTCCATGGGCGCTACTTCGAGAACCCGACGCCGGTGACCGGCCAGCCGTTCTGCGAGGTGCCGCGCTCCG
ACGCGGCCGACATCGACAAGGCGCTCGACGCCGCGCACGCGGCGGCGCCGGGGTGGGGCAAGACCGCACCGGCCGAACGG
GCGGCGATCCTCAACATGATTGCCGACCGCATCGACAAGAACGCCGCCGCGCTGGCGGTGGCCGAGGTCTGGGACAACGG
GAAACCGGTCCGGGAAGCGCTGGCCGCCGATATCCCGTTGGCGGTCGATCACTTCCGGTACTTCGCCGCGGCGATTCGCG
CCCAGGAGGGCGCGCTGAGCCAGATCGACGAGGACACCGTGGCCTACCACTTCCACGAGCCGCTCGGCGTGGTGGGCCAG
ATCATTCCGTGGAACTTCCCCATCCTGATGGCGGCCTGGAAGCTGGCGCCGGCGTTGGCGGCCGGCAACACGGCGGTGCT
CAAACCCGCCGAGCAGACACCCGCTTCGGTGCTCTACCTGATGTCGCTGATCGGTGATCTGTTGCCGCCCGGGGTGGTCA
ACGTGGTCAACGGATTCGGCGCCGAGGCCGGCAAGCCGTTGGCCTCCAGCGACCGCATCGCCAAGGTCGCGTTCACCGGG
GAAACCACCACGGGGCGGCTGATCATGCAATACGCCTCGCACAACCTGATCCCGGTCACCCTGGAACTCGGCGGCAAGAG
CCCCAACATCTTCTTCGCCGACGTGCTGGCCGCCCACGACGACTTCTGCGACAAGGCGCTGGAAGGCTTCACCATGTTCG
CCCTCAACCAGGGCGAGGTGTGCACCTGCCCGTCGCGCAGTCTGATCCAGGCCGACATCTACGACGAGTTCCTGGAGCTG
GCGGCGATCCGGACCAAGGCGGTCCGGCAGGGCGACCCGCTGGACACCGAAACCATGCTGGGTTCCCAGGCCTCCAACGA
CCAGCTGGAAAAGGTGTTGTCCTACATCGAAATCGGCAAGCAAGAGGGTGCGGTGATTATCGCCGGAGGCGAGCGCGCCG
AACTAGGCGGCGACCTGTCCGGCGGTTATTACATGCAGCCGACGATCTTCACCGGCACCAACAACATGCGGATTTTCAAG
GAGGAGATCTTCGGGCCGGTGGTCGCGGTGACGTCGTTCACCGATTACGACGACGCGATCGGCATCGCCAACGACACCCT
CTACGGCTTGGGTGCCGGTGTGTGGAGCCGCGACGGCAACACTGCCTATCGGGCCGGGCGGGACATCCAGGCCGGCCGGG
TGTGGGTCAACTGCTACCACCTCTACCCCGCGCACGCGGCGTTCGGCGGCTACAAGCAGTCCGGCATCGGCCGGGAGGGC
CACCAGATGATGCTGCAGCACTACCAGCACACCAAGAACCTGCTGGTGTCCTACTCGGATAAGGCGCTGGGGTTCTTCTG
A

Protein sequence :
MTVFSRPGSAGALMSYESRKNFIGGQWVAPVHGRYFENPTPVTGQPFCEVPRSDAADIDKALDAAHAAAPGWGKTAPAER
AAILNMIADRIDKNAAALAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDTVAYHFHEPLGVVGQ
IIPWNFPILMAAWKLAPALAAGNTAVLKPAEQTPASVLYLMSLIGDLLPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTG
ETTTGRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTMFALNQGEVCTCPSRSLIQADIYDEFLEL
AAIRTKAVRQGDPLDTETMLGSQASNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGTNNMRIFK
EEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTAYRAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREG
HQMMLQHYQHTKNLLVSYSDKALGFF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 4e-128 60
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 1e-132 59
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 1e-132 59
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 1e-132 59
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 6e-132 59
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 2e-57 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
M943_02375 YP_008224548.1 aldehyde dehydrogenase VFG0082 Protein 2e-128 60