Gene Information

Name : I876_14395 (I876_14395)
Accession : YP_008197261.1
Strain : Alteromonas macleodii Ionian Sea U7
Genome accession: NC_021717
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 3269364 - 3270803 bp
Length : 1440 bp
Strand : -
Note : COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

DNA sequence : 
ATGAACGCACAAGGCAGCTCTAATTGTTGTGCAAGCAAGGCGAAGCAACTTCATGTTGCTATTATTGGCAGTGGATCTGC
GGCATTCTCGTGCGCCATTAAAGCGGCAGAAAATGGTGCAAGGGTCACCATAATAGAAGGAGCCGACGTTATAGGCGGGT
GTTGTGTTAATGTCGGCTGCGTTCCATCTAAAATTCTCATCCGCGCCGCTCAATTAGCACATCAACAACGAAGCAACCCT
TTTACAGGCATTGAAGACCACGAACCTAAGATAGACCGCACGCTTTTATCGCATCAACAAATCAGTCGCGTTGACGAATT
GAGAACTGCCAAATACCAAAATATACTGAAAAACAATCCGGCATTAACCTTGATTAAGGGGTATGCGCGGTTTAGTAGCA
AAAATGCGCTGAACATTACCCATGCTGACGGTACAGAAGTAACACTACTTGCAGACAAATTTCTTATTGCAACAGGCTCA
ACACCCACTTTCCCTAAAATAGAAGGACTACAAAACACCCCATATTGGACTTCAACAGAAGCGTTGTTCGAAAAAGAGCT
ACCTAAGAGCCTTGCAGTAATTGGCTCATCGGTTGTCGCTGTAGAAATTGCTCAGGCATATGCTCGATTAGGTTGCCAAG
TTACTATTTTAGCGCGCAGTACCTTGTTGAAAAGTGAGGATCCACTGTTGGGTGATAGATTAAGTCAGTGTTTTGAGAAA
GAGGGCATTGAAATAATAAATAATACCCAAGTCACTCGAATCACTCATGATGACAATGGTTTTTTCATACAGACCGAAGA
TGAGCAAGTGCTCTGTGAGAAGTTATTGATATCTACAGGTCGTCACGCAAACACTGTAGGACTTGATTTAGATGTAGTAG
GTGTCAGGACCGATGGATCTGGCGCTGTCCTTGTTAATGAAAAGCTTGAGACAAATGTTTCTCATATCTACGCTGCAGGT
GATTGCTCAACCATACCTCAATATGTGTATGTTGCGGCGGCTGCAGGCAGCCGTGCCGGTTCAAATATGACTGGTGATAA
CTTGAAGCTAGACTTATCAATCATGCCTGCCGTTATTTTTACCGATCCGCAAGTTGCTACCGTTGGGTTATCAGAAGGTG
AAGCTGAAAATCAGGGAATAAGCGTTATTAGCCGCGTATTAGAAATGGAAAATGTGCCAAGAGCCTTAGCCAACTTTGAG
ACAGACGGTTTTATAAAGTTAGTGGCAGATAAACAGTCCAATAAGCTTATCGGTGCGCAAATCTTAGCACACGAAGGTGG
TGAGCTAATACAAAGTGCAGCCCTTGCTATACACAATCAAATGACAATTGAAGATTTAGCAAACCAGCTTTTTCCTTATC
TAACCATGGTTGAAGGTCTGAAACTGTGTGCGCAGACTTTTAATAAAGATGTGAGTGAGTTGTCTTGTTGCGCTGGATAA

Protein sequence : 
MNAQGSSNCCASKAKQLHVAIIGSGSAAFSCAIKAAENGARVTIIEGADVIGGCCVNVGCVPSKILIRAAQLAHQQRSNP
FTGIEDHEPKIDRTLLSHQQISRVDELRTAKYQNILKNNPALTLIKGYARFSSKNALNITHADGTEVTLLADKFLIATGS
TPTFPKIEGLQNTPYWTSTEALFEKELPKSLAVIGSSVVAVEIAQAYARLGCQVTILARSTLLKSEDPLLGDRLSQCFEK
EGIEIINNTQVTRITHDDNGFFIQTEDEQVLCEKLLISTGRHANTVGLDLDVVGVRTDGSGAVLVNEKLETNVSHIYAAG
DCSTIPQYVYVAAAAGSRAGSNMTGDNLKLDLSIMPAVIFTDPQVATVGLSEGEAENQGISVISRVLEMENVPRALANFE
TDGFIKLVADKQSNKLIGAQILAHEGGELIQSAALAIHNQMTIEDLANQLFPYLTMVEGLKLCAQTFNKDVSELSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 1e-113 58
merA AFG30120.1 MerA Not tested PAGI-2 Protein 1e-113 58
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 2e-113 58
merA AGK07079.1 MerA Not tested SGI1 Protein 4e-116 57
merA ABQ57371.1 MerA Not tested SGI1 Protein 4e-116 57
merA AGK07021.1 MerA Not tested SGI1 Protein 4e-116 57
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 2e-114 57
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 4e-111 55
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 1e-111 54
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 6e-112 54
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 2e-79 43
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 2e-79 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
I876_14395 YP_008197261.1 mercuric reductase BAC0653 Protein 2e-114 57
I876_14395 YP_008197261.1 mercuric reductase BAC0652 Protein 3e-114 56
I876_14395 YP_008197261.1 mercuric reductase BAC0650 Protein 6e-113 56
I876_14395 YP_008197261.1 mercuric reductase BAC0651 Protein 1e-79 43
I876_14395 YP_008197261.1 mercuric reductase BAC0224 Protein 8e-75 42