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Name : ureC (PSYCG_05170) Accession : YP_008162906.1 Strain : Psychrobacter sp. G Genome accession: NC_021661 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : - COG ID : - EC number : 3.5.1.5 Position : 1143202 - 1145334 bp Length : 2133 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGACGATGAAAGCAGGCGAATATAAGATTAAAGCAGGCGATATGGCATTGAATGCTGGTCGCTGCGTTCAAACCATAGC AGTAATCAATACAGGCGACCGCCCTATTCAAATCGGTTCTCATTATCACTTCTATGAAGTCAATGCAGCACTGAGCTTTG ATCGAGAGTCGACGCTTGGCTATCGACTCAATATCCTATCTGGCACTGCGGTACGCTTTGAGCCGGGACAAGCGCGCGAA GTGGAGCTGGTTGCCATCTCAGGTAGACAGCATATCTATGGTTTTGCGGGCAAAGTCATGGGCGTTGTAGACCCTAAAAC CTCTCAAAACACCTCGAAAAAACGCATTGACCGACGTATCTATGCCGAACATTTTGGCCCTACCACAGGGGACAAAGTAC GCTTGGCAGATACAAATTTATGGCTTGAGGTTGAGTATGATTTGACCAGTCATATTGATCACCAGCCTGATATTGATAGT GTTAGCATTGGTGAAGAGGTTAAATTTGGCGGCGGCAAGGTTATCCGCGATGGCATGGGTCAGTCACAGCTGCTGGGTGA GCAAGTTGCCGATACTATTATTACCAATGCTCTGATTGTGGACTACAGCGGTATCTATAAGGCAGATATCGCTATCAAAG AGGGTCGTATCAGTGGCATCGGTAAAGCTGGCAACCCTGATATTCAGCCTAACGTGACGTTACCTATTGGCGCTGCTACC GAAATCATCGCAGGAGAAGGTAAAATCTTGACTGCTGGCGGTATCGATAGTCATATTCATTTCATTGCACCGCAGCAATG TGAGACGGCGCTAATGTCTGGTGTAACCACAATGTTAGGCGGTGGCACGGGGCCTGCTGAAGGCACTCTTGCCACTACTT GTACGCCTGGTGCCTATCATATCCACAGCATGCTAAAAGCCACTGATGCTATTCCGATGAATATCGGATTCTTGGGTAAA GGCAATGTTAGTCTACCTGCCCCCATTGTTGAGCAGATTGAAGCGGGTGCTATCGGGCTTAAGCTTCATGAAGACTGGGG CTCCACGCCCAAAGCCATTGATAACTGCCTTAGCGTGGCTGAAGAATATGATGTGCAAGTGGCTATTCATACTGATACGT TAAATGAAAGCGGCTATTTAGATAGCACTCTAGGCGCATTTAAAGACCGCTGTATCCACACCTTCCATACCGAAGGCGCT GGCGGTGGTCATGCACCAGATATCTTAAAAGCTATTGGCGAAACCAATGTTTTACCCTCATCAACCAATCCAACGCGCCC TTTCACCATTAATACTATTGACGAGCATCTCGACATGCTCATGGTTTGTCACCACTTAAGCCCAGCCATTGCTGAAGATG TCGCTTTTGCAGAAAGCCGTATTCGTAAAGAAACCATTGCCGCTGAAGATATTTTACAAGATATGGGCGCTATCTCCATG ATGAGTAGTGATTCGCAAGCGATGGGACGCGTGGGTGAAGTCATTATTCGCACATGGCAAACGGCTGATAAAATGAAAGC CCAGCGTGGTCACCTTGCTCCTGATCAATCAGCTAAAACCGAGCAGTCCTTAGACAATATCATGCTAAGTCCTATTGATT CTGATAGCGGCAACGATAATTTTCGTATCAAACGCTACCTCGCAAAATACACCATCAATCCCGCCATTACCCATGGCATT AGTGATGAAGTAGGATCACTTGAGTTGGGAAAATGGGCAGATTTAGTGTTGTGGTCGCCTGCATTTTTTGGTGTCAAGCC TGATTTAATTATAAAAGGCGGTTTGATTGCAGCGGCACCTATGGGCGACCTCAATGCTTCCATTTCAACCCCGCAGCCTG TGCACTATCGCAGCATGTTTGGCAGCTTCCCCAAAACAGTGGCGCAGACTTGCATCACCTTTATGTCAAGTGCGGCTATT GATAAGGGTGTTGATAAGCAATTAGGGTTAGAAAAGGTCATTAAAGCGGTACACAACATTCGTAAGGTACGTAAACAAGA CATGAAGTTTAATAGCTACTGTCCTAAGATGGAGGTCAACCCGGAAACCTATGAAGTGTACGCCGATGGTGAGCTGCTGA CCTGTGAGCCTGCCGACTATCTACCGATGGCACAGCGCTATTTTTTATTCTAG Protein sequence : MTMKAGEYKIKAGDMALNAGRCVQTIAVINTGDRPIQIGSHYHFYEVNAALSFDRESTLGYRLNILSGTAVRFEPGQARE VELVAISGRQHIYGFAGKVMGVVDPKTSQNTSKKRIDRRIYAEHFGPTTGDKVRLADTNLWLEVEYDLTSHIDHQPDIDS VSIGEEVKFGGGKVIRDGMGQSQLLGEQVADTIITNALIVDYSGIYKADIAIKEGRISGIGKAGNPDIQPNVTLPIGAAT EIIAGEGKILTAGGIDSHIHFIAPQQCETALMSGVTTMLGGGTGPAEGTLATTCTPGAYHIHSMLKATDAIPMNIGFLGK GNVSLPAPIVEQIEAGAIGLKLHEDWGSTPKAIDNCLSVAEEYDVQVAIHTDTLNESGYLDSTLGAFKDRCIHTFHTEGA GGGHAPDILKAIGETNVLPSSTNPTRPFTINTIDEHLDMLMVCHHLSPAIAEDVAFAESRIRKETIAAEDILQDMGAISM MSSDSQAMGRVGEVIIRTWQTADKMKAQRGHLAPDQSAKTEQSLDNIMLSPIDSDSGNDNFRIKRYLAKYTINPAITHGI SDEVGSLELGKWADLVLWSPAFFGVKPDLIIKGGLIAAAPMGDLNASISTPQPVHYRSMFGSFPKTVAQTCITFMSSAAI DKGVDKQLGLEKVIKAVHNIRKVRKQDMKFNSYCPKMEVNPETYEVYADGELLTCEPADYLPMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 3e-178 | 64 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 3e-178 | 64 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 8e-159 | 58 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-158 | 58 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 1e-158 | 58 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-158 | 58 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_008162906.1 | urease subunit alpha | VFG0270 | Protein | 1e-157 | 60 |
