|
Name : ureC (PSYCG_04905) Accession : YP_008162854.1 Strain : Psychrobacter sp. G Genome accession: NC_021661 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : - COG ID : - EC number : 3.5.1.5 Position : 1081953 - 1083656 bp Length : 1704 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAAAATATCTCGCGACGCCTATGCCAATATGTATGGTCCGACTGTTGGCGACCGCATCCGTTTAGGCGATACTGAGCT TTGGATCGAGATTGAAAAAGACCACACTCATTATGGTGAAGAGGTAGTATTCGGTGGCGGTAAAGTGATTCGTGATGGTA TGGGTCAAAGCCAGTTGTGCTCAGACTCAGTGATGGATACTGTGATTACCAACGTGATTATTATTGATTGGTGGGGCATC GTAAAAGCCGATGTTGGCTTAAAAGATGGTCGCATTGCCGCTATTGGTAAAGCCGGCAACCCAGATACGCAGCCAGATGT TGATATTATTATTGGTGCAGGTACTGAGATTATCGCTGGTGAAAACCAAATCTTGACCGCAGGCGCAGTAGACACACACG TGCACTATATCTGCCCGCAACAAGTAGATGAGGCGTTAATGAGCGGCCTTACCACTATGATTGGTGGCGGTACTGGCCCT GCGACTGGCTCAGTCGCTACCACCAACACGCCTGGACCGTGGCACATTGGCAAAATGATGCAAGCCGTGGATGACCTGCC TATTAACATCGGATTTTTGGGTAAAGGCAGTGCCAGTACGCCTGCAGCACTTGAAGAGCAAGTCAAAGCTGGCGTGATGA GTTTAAAAGTTCATGAAGATTGGGCAGCAACGCCAGCAACCATTAGTAATGCGCTTGATGTTGCTGACCGTTACGATATT CAGGTAGCGTTACATGCCGATAGTTTAAATGAGTCAGGATTTGTTAAAGATACGCTAGAGGCCTTTAAAGATCGCTGTAT CCATTCGTATCATACTGAAGGTGCGGGTGGTGGTCACGCGCCAGATATTATTGTCGCTTGTGGTCAGCCAAATGTTTTAC CGTCATCGACCAATCCAACACGCCCGTACACCATCAACACTGTTGACGAGCATCTCGACATGCTGATGGAGTGTCATCAC TTAGACCCAAATATTCCTGAAGATGTGGCCTTTGCTGATTCGCGTATCCGCCGTGAGACCATTGCTGCAGAAGATATCTT GCATGATCTTGGCGCTATTTCGATGATTTCGTCGGACTCGCAAGCCATGGGCCGTATTGGTGAAGTTGTCTGCCGTACGT GGCAAACCGCGCACAAAATGCGGCTGCAACGTGGTCTGCTACCAGAAGATCAAGAGCGCGGTACTGATAACTTCCGAGTC AAACGTTATATTGCCAAATATACCATCAATCCTGCCATCACCCATGGTGTATCACATGAAGTGGGCTCGGTAGAGATTGG CAAAATGGCAGACTTGGTACTATGGCGTCCTAAGTTTTTTGGTGTTAAGCCGTCCATTATCTTAAAAGGCGGCATGATTG CTGGCGCAGCAATGGGTGATCCTAACGCCGCAATTTCGACCCCGCAGCCAGTACATTACCGCCGTATGTTTGGCGCGCTA GGACGTGCAGTTTCTGCTACACGTGTTACTTTCGTTAGCCAAGCTGCGATGAACACGGGACTCGAAGAAAAACTGGGGCT AAGAAGCCGATTGGTCGCGTGTAAAAACGTTCGTAGCATGCGCAAAAAAGACATGAAGCTGAATGATTACTGCCCGAACA TCACGGTAGATCCAGAAACTTATGAGGTTCGTGTAGACGGTGTGCTTTTAACGTGTGAGCCGCTCTCTGAACTGCCATTA GCTCAGCTTTATCATTTGTTTTAG Protein sequence : MKISRDAYANMYGPTVGDRIRLGDTELWIEIEKDHTHYGEEVVFGGGKVIRDGMGQSQLCSDSVMDTVITNVIIIDWWGI VKADVGLKDGRIAAIGKAGNPDTQPDVDIIIGAGTEIIAGENQILTAGAVDTHVHYICPQQVDEALMSGLTTMIGGGTGP ATGSVATTNTPGPWHIGKMMQAVDDLPINIGFLGKGSASTPAALEEQVKAGVMSLKVHEDWAATPATISNALDVADRYDI QVALHADSLNESGFVKDTLEAFKDRCIHSYHTEGAGGGHAPDIIVACGQPNVLPSSTNPTRPYTINTVDEHLDMLMECHH LDPNIPEDVAFADSRIRRETIAAEDILHDLGAISMISSDSQAMGRIGEVVCRTWQTAHKMRLQRGLLPEDQERGTDNFRV KRYIAKYTINPAITHGVSHEVGSVEIGKMADLVLWRPKFFGVKPSIILKGGMIAGAAMGDPNAAISTPQPVHYRRMFGAL GRAVSATRVTFVSQAAMNTGLEEKLGLRSRLVACKNVRSMRKKDMKLNDYCPNITVDPETYEVRVDGVLLTCEPLSELPL AQLYHLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 69 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 69 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-155 | 61 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-155 | 61 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 2e-155 | 61 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-155 | 61 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_008162854.1 | urease subunit alpha | VFG0270 | Protein | 3e-153 | 57 |
