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Name : ureC (SCE1572_13925) Accession : YP_008149222.1 Strain : Sorangium cellulosum So0157-2 Genome accession: NC_021658 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : - COG ID : - EC number : 3.5.1.5 Position : 3881604 - 3883325 bp Length : 1722 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGCCTTATCCGATCCCGCAATCCAGCTACGCGAGCCTGTACGGACCGACGGTGGGCCACAAGGTGCGGCTCGCCGACAC CGACCTCTTCATCGAGGTCGAGGCGGACCTCACCGCGTCCCACGGCTACGGCGAGGAGGTCACGTTCGGCGGCGGCAAGG CCATCCGCGACGGCATGGGCCAGTCGCAGAGGACACGGGCCGAGGGCGCCGTCGACACGGTGATCGTCAACGCGCTCATC CTCGATCACTGGGGCATCGTCAAGGCGGACATCGGCCTCAAGGACGGCCGGATCGCCGCGATCGGCAAGGCCGGCAACCC CGACGTGCAGGACGGCGTGACCATCGTCATCGGCCCCGGCACGGAGGTCATCGCGGGCTCCGGGAAGATCGTCACCGCCG GCGGCATCGACACGCACATCCATTTCATCTGCCCGCAGCTCGTCGAGGAGGCGCTCTCCTCGGGCCTGACCACGATGATC GGCGGGGGCACCGGACCGGCGGCGGGCACGACCGCGACGACCTGTACGCCCGGCCCCTTCCACATCCGGCGCATGCTCCA GGCGGCCGAGGCGCTGCCGATCAACATCGGCCTCTTCGGCAAGGGGAACACCAGCCGGCGCGAAGGGGCCATCGAGCAGA TCGAGGCCGGCGCCTGCGGGCTCAAGCTCCACGAGGACTGGGGCAGCACGCCGGCGGCCATCGACAACTGCCTCGCCGTG GCGGACGACTACGACGTTCAGGTGGCGCTCCACTCCGACACGCTGAACGAGGGCGGCTTCGTGCAGGACACGATCCGGGC CTTCAAGGGGCGCACGATCCACTCGTTCCACACCGAGGGGGCCGGCGGCGGCCATGCGCCCGACGTCATCGCGCTGGCCG GGGTGCCCAACGTGCTCCCGGCGTCCACGAACCCGACGCGTCCTTACACGGTGAACACGGTGGCGGAGCACAAGGACATG CTCATGGTCTGCCACCACCTCAACCCGAACATCGAGGAAGACTGCAAGTTCGCCGACAGCCGCATCCGGAAGGAGACGAT CGCCGCCGAGGACATCCTGCACGACATGGGGGCCATCTCCATCATGGCGAGCGACAGCCAGGCGATGGGGCGCGTCGGCG AGGTCATCCTGCGGACCTGGCAGACCGCCGACAAGATGAAGCGCCAGCGCGGGAAGCTGCCGGAGGAGACGCGGGACAAC GACAATTTCCGCGCCAAGCGGTATGTCGCCAAGTACACCATCAACCCGGCCATCGCCCAGGGCGTCAGCCGGCACATCGG CTCGGTCGAGGTCGGCAAGCTCGCCGATCTCGTGATCTGGTCGCCGGCCTTCTTCGGGGTCAAGCCGGACGTGGTGCTCA AGGGCGGCTCGATCGTCATGGCGCCGATGGGCGACCCCAACGCCGCCATCCCGACGCCGCAGCCCGTGCACTACCGGCCG ATGTTCGGGGCCTATGGCCGGAGCGCGATCGAGAGCTCGGTGCTGTTCGTCAGCCAGGCGTCGCTCGCGCGCGGGCTCGC GGCGGCCGCGGGGCTGTCGCGCCCGCTCATCGCGGTGGAGAACACCCGCTCGAAGATCTCGAAGGCGAGCATGATCCACA ACAGCGCCACGCCGAACATCGAGGTCGACCCGGAGCACTACACGGTGAAGGCCGACGGCGTGGTCCTCACGTGCGAGCCG GCGGACGTGCTCCCCATGGCCCAGCGCTACTTCCTGTACTGA Protein sequence : MPYPIPQSSYASLYGPTVGHKVRLADTDLFIEVEADLTASHGYGEEVTFGGGKAIRDGMGQSQRTRAEGAVDTVIVNALI LDHWGIVKADIGLKDGRIAAIGKAGNPDVQDGVTIVIGPGTEVIAGSGKIVTAGGIDTHIHFICPQLVEEALSSGLTTMI GGGTGPAAGTTATTCTPGPFHIRRMLQAAEALPINIGLFGKGNTSRREGAIEQIEAGACGLKLHEDWGSTPAAIDNCLAV ADDYDVQVALHSDTLNEGGFVQDTIRAFKGRTIHSFHTEGAGGGHAPDVIALAGVPNVLPASTNPTRPYTVNTVAEHKDM LMVCHHLNPNIEEDCKFADSRIRKETIAAEDILHDMGAISIMASDSQAMGRVGEVILRTWQTADKMKRQRGKLPEETRDN DNFRAKRYVAKYTINPAIAQGVSRHIGSVEVGKLADLVIWSPAFFGVKPDVVLKGGSIVMAPMGDPNAAIPTPQPVHYRP MFGAYGRSAIESSVLFVSQASLARGLAAAAGLSRPLIAVENTRSKISKASMIHNSATPNIEVDPEHYTVKADGVVLTCEP ADVLPMAQRYFLY |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 2e-169 | 67 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 2e-169 | 67 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 7e-151 | 61 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-152 | 61 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-152 | 61 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-152 | 61 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_008149222.1 | urease subunit alpha | VFG0270 | Protein | 2e-144 | 61 |
