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Name : ureC (M062_25690) Accession : YP_008135518.1 Strain : Pseudomonas aeruginosa RP73 Genome accession: NC_021577 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : - COG ID : - EC number : 3.5.1.5 Position : 5535623 - 5537323 bp Length : 1701 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAAAATCAGCAGACAAGCCTACGCCGACATGTTCGGCCCCACCGTCGGCGACCGCGTGCGCCTGGCCGACACCGACCT GTGGATCGAGGTGGAACGGGACTTCACCGTCTATGGCGAGGAAGTGAAGTTCGGCGGCGGCAAGGTCATCCGCGACGGCA TGGGCCAGAGCCAGCTGGGCGCGGCGCAGGTGGTCGACACGGTGATCACCAATGCGCTGATCCTCGACCACTGGGGCGTG GTCAAGGCCGACGTCGGTCTCAAGGACGGGCGCATCCAGGCCATCGGCAAGGCCGGCAACCCGGACATCCAGCCCGGGGT GAACATCGCCATCGGCGCCGGCACCGAGGTGATCGCCGGCGAGGGCATGATCCTCACCGCCGGCGGCATCGACACGCACA TCCACTTCATCTGCCCGCAGCAGATCGAAGAGGCGCTGATGAGCGGGGTCACCACCATGATCGGCGGCGGCACCGGCCCC GCCGCCGGGACCAACGCCACCACCTGCACCTCCGGTCCCTGGCACATGGCGCGGATGCTCCAGGCCGCCGACGCCTTCCC GATGAACATCGGCTTCACCGGCAAGGGCAACGCCAGCCTGCCGCTGCCGCTGGAGGAGCAGGTGCTCGCCGGCGCCATCG GCCTGAAGCTGCACGAGGACTGGGGCAGCACCCCGGCGGCGATCGACAACTGCCTGGAGGTCGCCGAGCGCCACGACATC CAGGTGGCGATCCACACCGACACCCTCAACGAATCCGGCTTCGTCGAGACCACCCTCGGCGCCTTCAAGGGCCGCACCAT CCACACCTACCACACCGAGGGCGCCGGTGGCGGCCACGCACCGGACATCATCAAGGCCTGCGGCTTCGCCAACGTGCTGC CCAGCTCGACCAACCCGACACGGCCGTTCACCCGCAATACCATCGACGAGCACCTGGACATGCTGATGGTCTGCCACCAC CTCGACCCGGCCATCGCCGAGGACGTGGCCTTCGCCGAGTCGCGCATCCGCCGCGAGACCATCGCCGCCGAGGACATCCT CCACGACCTCGGCGCGTTCAGCATGATCAGCTCCGACAGCCAGGCCATGGGCCGGGTCGGCGAAGTGATCACACGCACCT GGCAGACCGCCGACAAGATGAAGCGCCAGCGCGGCCGCCTCGACGGCGACGGTGCGCGCAACGACAACTTCCGCGCCAGG CGCTACATCGCCAAGTACACCATCAACCCGGCGATCACCCACGGCATCAGCCATGAAGTGGGCTCCGTCGAAGCCGGCAA GTGGGCCGACCTGGTGCTCTGGCGCCCGGCCTTCTTCGGCGTCAAGCCGAGCCTAATCCTCAAGGGCGGGGCCATCGCCG CCAGCCTGATGGGCGACATCAACGGCTCGATCCCCACGCCGCAGCCGGTGCACTACCGGCCGATGTTCGCCAGCTACGCC GGCAGCCGCCACGCGACCAGCCTGACCTTCGTCAGCCAGGCCGCCTTCGCCGCCGGCGTACCGCAGCAGCTCGGCCTGCG CAAGGCCATCGGCGTGGTCAGCGGCTGTCGCGGTGTGCAGAAGACCGACCTGATCCACAACGGCTACCTGCCGACCATCG AGGTCGACGCACAGAACTACCAGGTACGCGCCGACGGCCAGTTGCTCTGGTGCGAACCGGCGGACGTGCTGCCGATGGCG CAGCGCTATTTCCTGTTCTGA Protein sequence : MKISRQAYADMFGPTVGDRVRLADTDLWIEVERDFTVYGEEVKFGGGKVIRDGMGQSQLGAAQVVDTVITNALILDHWGV VKADVGLKDGRIQAIGKAGNPDIQPGVNIAIGAGTEVIAGEGMILTAGGIDTHIHFICPQQIEEALMSGVTTMIGGGTGP AAGTNATTCTSGPWHMARMLQAADAFPMNIGFTGKGNASLPLPLEEQVLAGAIGLKLHEDWGSTPAAIDNCLEVAERHDI QVAIHTDTLNESGFVETTLGAFKGRTIHTYHTEGAGGGHAPDIIKACGFANVLPSSTNPTRPFTRNTIDEHLDMLMVCHH LDPAIAEDVAFAESRIRRETIAAEDILHDLGAFSMISSDSQAMGRVGEVITRTWQTADKMKRQRGRLDGDGARNDNFRAR RYIAKYTINPAITHGISHEVGSVEAGKWADLVLWRPAFFGVKPSLILKGGAIAASLMGDINGSIPTPQPVHYRPMFASYA GSRHATSLTFVSQAAFAAGVPQQLGLRKAIGVVSGCRGVQKTDLIHNGYLPTIEVDAQNYQVRADGQLLWCEPADVLPMA QRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 73 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 73 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-159 | 61 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-159 | 61 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 4e-159 | 61 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-159 | 61 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_008135518.1 | urease subunit alpha | VFG0270 | Protein | 3e-156 | 62 |
