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Name : ureC (L483_12140) Accession : YP_008094214.1 Strain : Pseudomonas putida H8234 Genome accession: NC_021491 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : - COG ID : - EC number : 3.5.1.5 Position : 2612130 - 2613833 bp Length : 1704 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGCCGTATTTCCCGCCAGGCCTATGCCGACATGTTCGGGCCCACCGTGGGCGACCGCGTGCGGCTGGCCGACACGGC ATTGTGGGTAGAGGTGGAGAAGGACTACACAATCTACGGCGAAGAGGTGAAGTTTGGGGGCGGCAAGGTCATCCGCGACG GCATGGGGCAGGGCCAGATGCTGGCCGCTGAGGCCATGGACCTGGTGCTGACCAACGCGCTGATCATCGACCACTGGGGG ATCGTCAAGGCCGACATCGGCATCAAGCACGGGCGTATCGCGGTGATCGGCAAGGCCGGGAACCCGGATGTGCAGCCGGG CGTCAACGTCCCGGTGGGCCCCGGTACCGAAGTGATCGCGGCCGAGGGCAAGATCGTGACGGCGGGGGGTGTCGATTCGC ATATCCATTTCATCTGCCCGCAGCAGGTGGACGAGGCACTGAACAGCGGCGTCACGACCTTTATCGGCGGCGGCACCGGC CCGGCCACCGGCACCAATGCAACCACCTGCACGCCTGGCCCTTGGTACCTGGCGCGTATGCTACAGGCCGCCGACAGTCT GCCCATCAACATCGGTTTGCTGGGCAAGGGCAATGCCTCGCGGCCAGAAGCGCTGCGTGAGCAGATCGCGGCCGGTGCGG TGGGCCTCAAGCTGCATGAAGACTGGGGCTCGACCCCGGCGGCTATCGACTGCTCGCTGGGCGTTGCAGAGGAAATGGAC GTCCAGGTGGCGATCCATACCGACACCCTCAACGAGTCCGGTTGCATCGAAGACACCCTGGCGGCCATCGGCGACCGGAC CATCCACACCTTCCACACCGAAGGTGCCGGCGGTGGCCACGCGCCGGACATCATTCGCGCTGCGGGGCAGGCCAACGTGC TGCCATCCTCGACCAATCCGACCCTGCCGTACACGGTCAACACCGTGGACGAGCACCTGGACATGCTCATGGTCTGCCAT CACCTGGACCCGAGCATTGCGGAGGACGTGGCCTTTGCCGAATCGCGCATCCGCCGCGAAACCATCGCCGCCGAGGACAT CCTTCACGACATGGGTGCATTTGCCATGACCTCGTCCGACTCTCAGGCCATGGGCCGGGTCGGTGAAGTGGTGCTGCGCA CCTGGCAGGTTGCCCACCAGATGAAACTGCGTCGTGGGCCTTTGGCGCCAGACACGGCCTACAGCGACAACTTCCGGGTC AAGCGCTACATCGCCAAGTACACCATCAACCCCGCGTTAACCCACGGCATTGGCCACGAAGTGGGTTCGGTGGAGGCGGG CAAGCTGGCCGACCTGGTGCTGTGGTCGCCGGCGTTCTTCGCGGTCAAGCCGGCCCTGGTGATCAAAGGCGGGATGATCG TCACCGCGCCCATGGGCGACATCAACGGCTCCATTCCCACACCGCAGCCGGTGCACTACCGGCCGATGTTCGGCGCCCTC GGCGCCGCACGGCATGCCACGCGCATGACCTTCCTGCCCCAGGCGGCAATGGACCGCGGCCTGGCCGAGGAGCTGAACCT GCGCAGCCTGATTGGGGTGGTCAACGGCTGCCGCCGCGTGCGCAAGCCGGACATGGTCCACAACACCTTGCAGCCGCTGA TCGAAGTCGATGCGCAGACCTACCAGGTGCGTGCCGACGGCGAATTGCTGGTCTGCGAGCCCGCCAGCGAACTGCCGCTG GCACAGCGTTATTTCCTGTTTTGA Protein sequence : MSRISRQAYADMFGPTVGDRVRLADTALWVEVEKDYTIYGEEVKFGGGKVIRDGMGQGQMLAAEAMDLVLTNALIIDHWG IVKADIGIKHGRIAVIGKAGNPDVQPGVNVPVGPGTEVIAAEGKIVTAGGVDSHIHFICPQQVDEALNSGVTTFIGGGTG PATGTNATTCTPGPWYLARMLQAADSLPINIGLLGKGNASRPEALREQIAAGAVGLKLHEDWGSTPAAIDCSLGVAEEMD VQVAIHTDTLNESGCIEDTLAAIGDRTIHTFHTEGAGGGHAPDIIRAAGQANVLPSSTNPTLPYTVNTVDEHLDMLMVCH HLDPSIAEDVAFAESRIRRETIAAEDILHDMGAFAMTSSDSQAMGRVGEVVLRTWQVAHQMKLRRGPLAPDTAYSDNFRV KRYIAKYTINPALTHGIGHEVGSVEAGKLADLVLWSPAFFAVKPALVIKGGMIVTAPMGDINGSIPTPQPVHYRPMFGAL GAARHATRMTFLPQAAMDRGLAEELNLRSLIGVVNGCRRVRKPDMVHNTLQPLIEVDAQTYQVRADGELLVCEPASELPL AQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 0.0 | 78 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 0.0 | 78 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-155 | 62 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-155 | 62 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 2e-155 | 62 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-155 | 62 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_008094214.1 | urease subunit alpha | VFG0270 | Protein | 1e-153 | 62 |
