Gene Information

Name : fliI (TPANIC_0402)
Accession : YP_008091251.1
Strain : Treponema pallidum Nichols
Genome accession: NC_021490
Putative virulence/resistance : Virulence
Product : IIISP family Type III (virulence-related) secretory pathway protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 428195 - 429538 bp
Length : 1344 bp
Strand : +
Note : flagellum-specific ATP synthase FliI

DNA sequence :
ATGGAAGCAGACCTGTTGTGCAAGTATGAGGTGGCGCTCCGCGAGAGTGAGCCGGTAAAGTACGTTGGGCATGTGACAGC
AGTGAGGGGTTTATTGATTGAAAGTCGTGGCCCTCACGCGGTAGTTGGTGAATTGTGTCGGATTGTGTTGCGCCGCCAGG
GGCGACCGTTGATAGCAGAGGTAGTAGGACTTGCAGGATCGACGGTAAAACTGATGAGCTACACCGATACGCACGGGGTT
GAAGTTGGCTGTGCGGTGGTAGCAGAAGGGGCGGCACTTTCAGTCCCCGTAGGAGATGCTTTACTCGGACGCGTTTTGAA
CGCGTTTGGGAAGGCAATTGACGGGAAGGGGGAGATATATGCGCCGCTCCGCTCCGAGGTGTTGCGCGCGTCTTCTAATC
CTATGGAGCGTCTTCCGATTACGCGTCAAATGGTAACAGGAGTGCGGGTGCTTGATTCGTTGCTGGCAGTTGGTTGCGGA
CAACGTCTGGGTATTTTTTCCGGTTCGGGGGTTGGGAAGTCGACGCTGATGGGGATGATCGCGCGCAATACAGACGCAGA
TGTGTCGGTCATTGCCCTTATCGGGGAGCGTGGCCGTGAAGTGATGGATTTTGTTGCGCATGATTTGGGTCCTGAGGGTT
TGAAGCGCTCGGTAATAGTTAGTGCGACGTCTGATGAAAGTCCGCTTGCGCGGGTACGAGGTGCGTACACGGCGACAGCG
ATTGCAGAGTACTTTCGGGATCAAGGCAAACAGGTGCTGCTGCTGTTTGATTCTCTGACGCGCTTTGCAAAAGCTCAGCG
TGAGATTGGGTTAGCGTCGGGGGAGCTCCCTGCAACGCGTGGATATACCCCGGGGGTATTCGAAACGTTACCGAAACTGC
TTGAGCGTGCAGGTTCTTTTTCCATGGGGAGCGTCACCGCTTTTTATACTGTTTTGGTAGATGGGGACGATCTCGATGAG
CCGATATCAGACGCCGTGCGTGGAATTGTAGACGGGCACATTGTACTCAGTCGCGCGCTTGCGCAGCGCAATCACTATCC
TGCAATAGACGTGTTGCAAAGCGTTTCTCGCTTGGCGCACCGCGTGCTGGGTGCAGACATGAAAGAGGCAGTGCGCATAG
TGCGTCGTGCGCTTGCAGTGTACGCAGAAGTAGAGGATTTGGTACGAGTTGGTGCGTACCAGCAGGGGAGTGATGCAGAA
CTTGATCGAGCTATTGCGATGCGCGCAGAGCTTGAACGGTTCCTAACGCAAGGAGCCCAGGAGCGCGTGCGTTTTCAGGA
TACTGTAACGTCGCTGTCCATGCTGACAGGGCTCAGTATAGCACAGCCGCCTTCGGGTGTGTGA

Protein sequence :
MEADLLCKYEVALRESEPVKYVGHVTAVRGLLIESRGPHAVVGELCRIVLRRQGRPLIAEVVGLAGSTVKLMSYTDTHGV
EVGCAVVAEGAALSVPVGDALLGRVLNAFGKAIDGKGEIYAPLRSEVLRASSNPMERLPITRQMVTGVRVLDSLLAVGCG
QRLGIFSGSGVGKSTLMGMIARNTDADVSVIALIGERGREVMDFVAHDLGPEGLKRSVIVSATSDESPLARVRGAYTATA
IAEYFRDQGKQVLLLFDSLTRFAKAQREIGLASGELPATRGYTPGVFETLPKLLERAGSFSMGSVTAFYTVLVDGDDLDE
PISDAVRGIVDGHIVLSRALAQRNHYPAIDVLQSVSRLAHRVLGADMKEAVRIVRRALAVYAEVEDLVRVGAYQQGSDAE
LDRAIAMRAELERFLTQGAQERVRFQDTVTSLSMLTGLSIAQPPSGV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 4e-88 50
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 3e-89 50
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 3e-89 50
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-88 50
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 4e-89 50
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-85 49
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-85 49
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 7e-86 49
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 1e-88 49
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-88 49
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 5e-85 49
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 5e-85 49
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-87 49
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-87 49
lscN AAO18044.1 LscN Virulence TTSS locus Protein 2e-86 48
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 2e-70 47
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 7e-73 47
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-73 47
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 3e-73 47
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 1e-69 46
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 1e-69 46
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 1e-74 46
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 1e-67 45
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-79 45
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 3e-79 45
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 4e-80 44
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 2e-73 44
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 7e-74 44
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 3e-81 44
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 6e-73 44
unnamed AAL06369.1 EscN Virulence LEE Protein 3e-81 44
escN CAC81862.1 EscN protein Virulence LEE II Protein 2e-80 43
escN CAI43874.1 EscN protein Virulence LEE Protein 9e-81 43
escN AAC38383.1 EscN Virulence LEE Protein 5e-81 43
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 2e-80 43
escN YP_003223475.1 translocator EscN Virulence LEE Protein 1e-80 43
escN NP_290268.1 hypothetical protein Virulence LEE Protein 3e-81 43
escN AAC31513.1 L0034 Virulence LEE Protein 2e-81 43
ECs4568 NP_312595.1 EscN Virulence LEE Protein 3e-81 43
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 2e-81 43
escN YP_003236088.1 translocator EscN Virulence LEE Protein 1e-81 43
invC AAS66861.1 InvC Not tested SSR-2 Protein 5e-66 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 4e-68 42
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 1e-64 42
escN AAK26715.1 EscN Virulence LEE Protein 6e-80 42
escN AAL57542.1 EscN Virulence LEE Protein 6e-80 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2144 Protein 3e-93 51
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0048 Protein 5e-89 49
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0515 Protein 4e-86 49
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0192 Protein 4e-93 49
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG1254 Protein 2e-81 49
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0390 Protein 2e-88 48
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2499 Protein 1e-80 47
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2331 Protein 5e-78 46
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2459 Protein 5e-68 43
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0730 Protein 3e-81 43
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0812 Protein 1e-81 43
fliI YP_008091251.1 IIISP family Type III (virulence-related) secretory pathway protein VFG1778 Protein 8e-68 41