Gene Information

Name : topB (KPR_2253)
Accession : YP_007991232.1
Strain : Klebsiella pneumoniae SB3432
Genome accession: NC_021232
Putative virulence/resistance : Unknown
Product : hypothetical protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2347945 - 2349891 bp
Length : 1947 bp
Strand : +
Note : highly similar to DNA topoisomerase 3 from Escherichia coli strain K12 (sp|P14294)

DNA sequence :
ATGCGGTTGTTTATTGCAGAAAAACCGAGTCTCGGTCGGGCTATCGCCGATGTGTTGCCTAAACCGCACCGCAAAGGCGA
TGGCTATATTGAGTGCGGCAACGGGCAGGTGGTCACCTGGTGTATCGGCCACCTGCTGGAGCAGGCGCAGCCGGACATCT
ACGACAGCCGCTATGCCCGGTGGAATCTCAACGATCTGCCGATTGTGCCGGAGAAATGGCAGCTGCAGCCAAAGCCCTCG
GTCACCAAACAGCTGAATGTCATCAAGCGCCTGCTCGGCGACGCCGAGGAGGTTATCCACGCCGGCGACCCGGACAGAGA
AGGGCAGCTGCTGGTGGACGAAGTACTCGACTACCTACAGCTGGCGCCGGAGAAGCGTCAGCAGGTGCAGCGCTGTCTGA
TTAACGATCTCAACCCGCAGGCGGTGGAGCGGGCGATCAACCGTCTGCGCGCCAACAGCGAGTTCGTGCCGCTCTGCGTG
TCGGCGCTGGCGCGGGCCCGCGCCGACTGGCTGTACGGCATCAATATGACCCGCGCCTACACCCTGCTGGGGCGCAACGC
CGGCTATCAGGGGGTGCTCTCGGTGGGGCGGGTGCAGACCCCGGTACTTGGCCTGGTGGTCCGTCGCGATGAAGAGATTG
AAAATTTCGTCGCCAAAGATTTCTTCGACGTGAAGGCGCATATCGTCACGCCGCAGGAGGAGCGTTTTGTCGCCACCTGG
GTGCCGAGCGAAGCCTGCGAACCTTACCAGGATGAAGAAGGGCGCCTGCTGCATCGTCCGCTGGCCGAGCATGTGGTTAA
GCGCATCGAAGGCCAGCCGGCAATCGTGACCGGCTATAACGATAAGCGCGATTCCGAACCCGCGCCGCTGCCGTTCTCGC
TGTCGGCGCTGCAGATTGAGGCGGCCAAACATTTCGGCTTCAGCGCGCAGAACGTGCTGGATATCTGCCAGAAGCTGTAC
GAAACCCACAAACTCATCACCTATCCGCGTTCGGACAGCCGCTATCTGCCGGAAGAGCACTTCGCTGGCCGCCATGCGGT
GTTGAATGCGATTGCCGTCCATGCGGCGGACCTGCTGCCGCAGCCGGTAGTGGATCCGGAGATCCGCAACCGCTGCTGGG
ATGATAAAAAGGTCGACGCGCACCATGCGATTATCCCAACTGCCCGCAGCAGCCAGGTGAAGCTCACCGATAACGAAGCG
AAGGTGTACACCCTGATCGCCCGCCAGTATCTGATGCAGTTCTGCCCTGACGCAGTGTTCCGCAAATGCCAGATTGATCT
TGAGATCGCCAACGGCAAGTTTGTCGCCAAGGCGCGTTTTCTGGCCGAGGCGGGCTGGCGGACGCTGCTTGGCAGCAAAG
AGCGCGATGAAGAGAACGACGGCACGCCGCTGCCGGTGGTGGCCAAAGGCGATGAACTGCTGTGCGAGAGGGGCGAGGTG
GTGGAGCGTCAGACCCAGCCGCCGCGCCACTTTACCGACGCCACGCTGCTGTCGGCGATGACCGGGATTGCCCGCTTCGT
GCAGGATAAAGATTTGAAGAAGATCCTCCGCGCCACCGACGGCCTCGGCACGGAAGCGACCCGCGCAGGGATTATCGAGC
TGCTGTTCAAGCGTGGTTTCCTGAGCAAAAAGGGGCGCTATATCCACTCTTCGGAGGCCGGCAGGGCGCTCATTCATTCC
CTGCCGGAGATGGCCGGGCGACTGGACATGACCGCCCACTGGGAGTCGGTGTTGACGCAGATCAGCGAGAAACAGTGCCG
CTATCAGGACTTTATGCAGCCGCTGGTGGGGACGCTGTATCAACTGATCGAGCAGGCGCGCAGCACGCCGGTGCGTCAGT
TCCGCGGCCTGGTGGCGCCGGGCGGGGCGAAGAAGTCGTTCAGCACAGGTAAAGGGAAGCCGAAAGGCAAAAAAGCGGCA
GACGATACCGCGCCGCCGCCGCAGTAA

Protein sequence :
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDIYDSRYARWNLNDLPIVPEKWQLQPKPS
VTKQLNVIKRLLGDAEEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCV
SALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATW
VPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKHFGFSAQNVLDICQKLY
ETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEA
KVYTLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCERGEV
VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLSKKGRYIHSSEAGRALIHS
LPEMAGRLDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQARSTPVRQFRGLVAPGGAKKSFSTGKGKPKGKKAA
DDTAPPPQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 2e-105 41
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 5e-102 41
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 4e-109 41