Gene Information

Name : K749_08860 (K749_08860)
Accession : YP_008357709.1
Strain : Helicobacter pylori UM299
Genome accession: NC_021216
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 1321505 - 1322647 bp
Length : 1143 bp
Strand : +
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.

DNA sequence :
ATGCGCATGCAAACAAAATTAATCCATGGGGGTATTAGTGAGGACGCAGTAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCATAAGGGCTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CTTTAGAAGAACTTATCGCCGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGTTTAGCTGGGATCCACGCC
GTTTTTTCTCTCTTGCAATCAGGCGATCATGTGCTATTAGGCGATGATGTTTATGGGGGGACTTTTCGCTTGTTCAATAA
AGTGCTTGTTAAAAACGGGCTTTCTTGCACCATTATAGACACTAGCGATCTATCCCAAATCAAAAAGGCTATCAAGCCCA
ACACCAAAGCCCTTTATTTGGAAACCCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGTGCAATGCGCTAGTGTTGCT
AAAGATCATGGTTTGCTCACTATCGTGGATAACACTTTTGCCACCCCCTATTGCCAAAACCCTCTTCTTTTGGGGGCGGA
TATTGTGGCACATAGCGGCACAAAATACTTAGGCGGTCATAGCGATGTGGTCGCCGGGCTTGTAACCACTAATAATGAAG
CGCTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTAGGATTGCGCATGGAGGCCCACCAAAAAAATGCCCTTTACGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTGGAAAAGGTTTATTACCCGGGTCTTCCCACTCACCCTAACCACGAACTGGCCAAAAAACAGATGCGTGGCTTTA
GTGGGATGCTCTCTTTCACTCTCAAAAATGACAGCGAGGCGGTTACTTTTGTAGAAAGCCTTAAACTATTCATTTTGGGC
GAGAGTTTGGGCGGAGTGGAAAGTTTGGTGGGGATTCCAGCGCTTATGACCCATGCGTGTATCCCTAAAGTGCAACGAGA
AGCTGCCGGGATTAGAGATGGCCTGGTGCGCTTGTCTGTGGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAGGCTAA

Protein sequence :
MRMQTKLIHGGISEDAVTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLVQCASVA
KDHGLLTIVDNTFATPYCQNPLLLGADIVAHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALYVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSEAVTFVESLKLFILG
ESLGGVESLVGIPALMTHACIPKVQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAKIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-96 55
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-97 55
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-73 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
K749_08860 YP_008357709.1 cystathionine beta-lyase BAC0207 Protein 2e-61 43