Gene Information

Name : lysS (J113_11390)
Accession : YP_007961535.1
Strain : Mycobacterium tuberculosis CAS/NITR204
Genome accession: NC_021193
Putative virulence/resistance : Unknown
Product : lysyl-tRNA ligase
Function : -
COG functional category : -
COG ID : -
EC number : 6.1.1.6
Position : 1843177 - 1846689 bp
Length : 3513 bp
Strand : -
Note : COG2898 Uncharacterized conserved protein

DNA sequence :
GTGGGACTCCACTTAACTGTCCCTGGCCTTCGCCGGGATGGTCGCGGCGTCCAGTCTAACAGCCATGACACGTCATCTAA
GACAACGGCCGACATCAGCCGGTGCCCTCAGCACACCGATGCGGGGCTACAAAGGGCTGCAACGCCGGGCATTTCCCGGC
TTTTGGGAATATCCTCGCGGTCTGTGACACTCACCAAACCTCGCTCGGCCACCAGGGGAAACTCCCGGTATCACTGGGTT
CCCGCGGCAGCCGGCTGGACCGTCGGCGTGATCGCGACCCTGTCACTACTGGCCAGTGTGTCGCCGTTGATTCGGTGGAT
CATCAAGGTTCCGCGCGAATTCATCAACGATTATCTGTTCAACTTCCCCGACACCAACTTCGCGTGGTCCTTCGTGCTGG
CATTGCTGGCCGCCGCGTTAACGGCACGCAAACGCATTGCCTGGTTGGTCTTGCTGGCAAATATGGTCCTGGCCGCCGTG
GTCAACGCCGCCGAGATCGCAGCGGGCGGCAACACCGCCGCCGAGAGCTTCGGGGAGAATCTCGGATTCGCCGTGCATGT
TGTGGCAATCGTCGTTCTGGTGCTGGGCTATCGGGAGTTCTGGGCCAAGGTCCGCAGGGGCGCGCTGTTTCGGGCGGCTG
CGGTGTGGCTTGCCGGCGCGGTGGTCGGAATCGTGGCGTCTTGGGGTCTGGTCGAACTGTTTCCGGGATCACTAGCGCCG
GACGAGCGGTTGGGTTACGCGGCCAACCGGGTGGTCGGATTCGCCCTCGCCGATCCCGATCTGTTCACCGGCAGACCGCA
CGTCTTCCTCAACGCGATCTTCGGGTTGTTCGGCGCGTTCGCGTTGATCGGGGCTGCGATCGTCTTGTTCCTATCTCAGC
GCGCTGACAATGCGCTGACCGGAGAGGACGAATCCGCTATCCGCGGGTTATTGGATTTGTATGGGAAGGACGACTCACTG
GGCTACTTCGCCACCCGTCGCGACAAGTCGGTGGTATTCGCATCCAGCGGCCGCGCCTGTATCACCTACCGTGTCGAGGT
CGGTGTCTGCCTAGCCAGCGGCGACCCGGTAGGCGACCACAGAGCATGGCCGCAGGCCGTCGACGCGTGGCTGCGGCTGT
GCACCTGGCCGGGCCCCGGCGTGATGGGCGCCAGTTCACAAGGGGCTCAGACATATCGCGAAGCGGGCCTAACCGCGCTC
GAGCTGGGCGATGAGGCCATCCTGCGGCCAGCCGATTTCAAGTTGTCCGGCCCGGAGATGCGCGGGGTGCGCCAGGCCGT
GACGCGGGCCCGGCGGGCGGGGTTGACGGTGCGCATCCGGCGGCATCGCGACATTGCCGAAGACGAGATGGCGCAGACCA
TCACACGGGCGGATTCCTGGCGCGACACCGAGACCGAGCGCGGCTTCTCGATGGCGCTGGGCCGCCTCGGCGACCCCGCG
GACTCCGACTGCCTGCTGGTGGAGGCGATTGATCCGCACAACCAGGTGCTGGCAATGCTGTCGCTGGTGCCGTGGGGAAC
CACCGGTGTCTCCCTGGATTTGATGCGTCGTTCTCCACAATCCCCGAACGGCACTATCGAACTTATGGTCAGCGAACTCG
CCTTGCACGCTGAAAGCCTTGGTATCACTCGTATTTCGTTGAACTTCGCGGTGTTTCGCGCGGCCTTCGAGCAGGGCGCC
CAACTCGGCGCCGGCCCGGTTGCCCGGTTGTGGCGGGGGCTGCTGGTCTTCTTCTCACGGTGGTGGCAGCTCGAGACGCT
CTACCGCTCCAACATGAAGTACCAACCCGAATGGGTACCGCGCTACGCCTGCTACGAAGACGCCCGAGTGATTCCCCGAG
TGGGCGTCGCCTCGGTGATCGCAGAGGGGTTCCTCGTGCTGCCGTTCAGCCGGCGCAACCGAGTACACACGGGGCATCAT
CCGGCAGTGCCCGAGCGGTTGGCGGCCACCGGCCTATTGCATCACGACGGCTCGGCACCGGACGTGAGCGGGCTGCGGCA
AGTAGGCCTCACCAATGGCGACGGGGTCGAGCGGCGGCTACCCGAGCAGGTGCGAGTTCGGTTCGACAAGCTAGAGAAGC
TGCGGAGCAGCGGCATTGACGCCTTTCCCGTGGGCCGGCCGCCCAGTCACACGGTGGCACAGGCGCTGGCCGCAGACCAC
CAGGCTAGCGTGTCGGTGTCCGGACGCATCATGCGAATACGTAACTACGGTGGTGTGTTGTTCGCCCAGCTGCGCGACTG
GTCGGGCGAAATGCAAGTGCTGCTGGATAATTCACGCCTGGACCAGGGCTGCGCGGCCGACTTCAACGCGGCGACCGATC
TGGGTGATCTGGTGGAGATGACCGGACACATGGGCGCCAGCAAGACCGGAACTCCATCGTTGATCGTCAGCGGCTGGCGC
CTGATCGGTAAGTGTTTGCGGCCGTTGCCGAATAAGTGGAAGGGGCTACTGGATCCCGAAGCCCGAGTCCGGACCCGTTA
CCTCGACCTGGCGGTCAACGCTGAGTCCCGTGCGCTGATCACCGCTCGCAGCAGCGTGCTGCGCGCTGTGCGCGAGACGC
TGTTCGCAAAGGGATTCGTCGAGGTCGAAACGCCGATCCTACAGCAGCTGCACGGCGGCGCCACCGCCCGACCGTTCGTC
ACGCACATCAACACGTATTCCATGGATCTGTTCCTGCGCATCGCACCAGAGCTCTACCTCAAGCGCCTGTGCGTCGGCGG
CGTGGAACGGGTATTCGAGCTCGGCCGTGCCTTTCGCAACGAGGGCGTCGACTTCAGCCACAACCCGGAGTTCACCCTAC
TGGAGGCCTATCAAGCACACGCCGACTACCTTGAGTGGATTGACGGCTGCCGCGAACTCATCCAGAACGCCGCCCAGGCC
GCCAACGGGGCGCCCATCGCCATGCGGCCCCGGACGGACAAGGGTTCCGACGGCACCCGCCACCACCTCGAACCGGTCGA
CATCTCCGGGATATGGCCGGTGCGGACGGTGCATGATGCGATCTCGGAAGCACTCGGTGAACGCATCGACGCCGATACCG
GCTTTACCACTCTCCGCAAGCTGTGCGACGCCGCCGGTGTCCCCTATCGGACCCAATGGGATGCCGGCGCGGTCGTGCTC
GAGCTATACGAGCACCTGGTGGAGTGCCGCACCGAGCAACCGACGTTCTACATCGACTTTCCGACATCGGTGTCACCGTT
GACCCGACCGCATCGCAGCAAGCGCGGTGTCGCCGAGCGTTGGGACCTGGTGGCGTGGGGTATCGAGCTGGGCACCGCCT
ACAGCGAGCTGACCGACCCGGTGGAGCAACGGCGCCGCCTGCAGGAGCAGTCCCTGCTGGCCGCCGGCGGAGACCCCGAG
GCGATGGAACTCGACGAAGACTTCCTGCAAGCGATGGAGTACGCCATGCCGCCCACCGGCGGCTTGGGCATGGGCATTGA
CCGGGTGGTCATGCTGATCACTGGGCGCAGCATTCGCGAAACACTGCCCTTTCCGTTGGCAAAACCGCATTAG

Protein sequence :
MGLHLTVPGLRRDGRGVQSNSHDTSSKTTADISRCPQHTDAGLQRAATPGISRLLGISSRSVTLTKPRSATRGNSRYHWV
PAAAGWTVGVIATLSLLASVSPLIRWIIKVPREFINDYLFNFPDTNFAWSFVLALLAAALTARKRIAWLVLLANMVLAAV
VNAAEIAAGGNTAAESFGENLGFAVHVVAIVVLVLGYREFWAKVRRGALFRAAAVWLAGAVVGIVASWGLVELFPGSLAP
DERLGYAANRVVGFALADPDLFTGRPHVFLNAIFGLFGAFALIGAAIVLFLSQRADNALTGEDESAIRGLLDLYGKDDSL
GYFATRRDKSVVFASSGRACITYRVEVGVCLASGDPVGDHRAWPQAVDAWLRLCTWPGPGVMGASSQGAQTYREAGLTAL
ELGDEAILRPADFKLSGPEMRGVRQAVTRARRAGLTVRIRRHRDIAEDEMAQTITRADSWRDTETERGFSMALGRLGDPA
DSDCLLVEAIDPHNQVLAMLSLVPWGTTGVSLDLMRRSPQSPNGTIELMVSELALHAESLGITRISLNFAVFRAAFEQGA
QLGAGPVARLWRGLLVFFSRWWQLETLYRSNMKYQPEWVPRYACYEDARVIPRVGVASVIAEGFLVLPFSRRNRVHTGHH
PAVPERLAATGLLHHDGSAPDVSGLRQVGLTNGDGVERRLPEQVRVRFDKLEKLRSSGIDAFPVGRPPSHTVAQALAADH
QASVSVSGRIMRIRNYGGVLFAQLRDWSGEMQVLLDNSRLDQGCAADFNAATDLGDLVEMTGHMGASKTGTPSLIVSGWR
LIGKCLRPLPNKWKGLLDPEARVRTRYLDLAVNAESRALITARSSVLRAVRETLFAKGFVEVETPILQQLHGGATARPFV
THINTYSMDLFLRIAPELYLKRLCVGGVERVFELGRAFRNEGVDFSHNPEFTLLEAYQAHADYLEWIDGCRELIQNAAQA
ANGAPIAMRPRTDKGSDGTRHHLEPVDISGIWPVRTVHDAISEALGERIDADTGFTTLRKLCDAAGVPYRTQWDAGAVVL
ELYEHLVECRTEQPTFYIDFPTSVSPLTRPHRSKRGVAERWDLVAWGIELGTAYSELTDPVEQRRRLQEQSLLAAGGDPE
AMELDEDFLQAMEYAMPPTGGLGMGIDRVVMLITGRSIRETLPFPLAKPH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lysS1 YP_005686365.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 2e-152 43
lysS1 YP_005682181.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 5e-152 43
lysS1 YP_005684273.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 2e-152 43
lysX YP_003784331.1 lysyl-tRNA synthetase Not tested PiCp 7 Protein 2e-152 43