Gene Information

Name : I917_06355 (I917_06355)
Accession : YP_007957056.1
Strain : Mycobacterium tuberculosis Haarlem/NITR202
Genome accession: NC_021192
Putative virulence/resistance : Virulence
Product : two component response transcriptional regulatory protein PRRA
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1008078 - 1008788 bp
Length : 711 bp
Strand : -
Note : COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

DNA sequence :
ATGGGCGGCATGGACACTGGTGTGACCTCACCTCGGGTGTTGGTCGTCGACGACGACTCCGATGTGCTCGCCTCGCTGGA
ACGCGGCTTACGGCTGTCCGGATTCGAGGTAGCGACCGCGGTGGACGGCGCCGAGGCCTTGCGCAGCGCCACCGAGAACC
GGCCGGACGCGATCGTGCTCGACATCAACATGCCAGTGCTCGATGGAGTCAGCGTCGTGYCGGCACTACGCGCGATGGAC
AACGACGTCCCGGTCTGTGTGCTATCCGCACGCAGCTCTGTCGATGACCGAGTGGCCGGATTGGAGGCCGGCGCCGACGA
TTACCTGGTGAAKCCGTTCGTGCTGGCCGAGCTGGTGGCACGGGTGAAGGCGCTGCTGCGCCGCCGCGGCTCCACTGCAA
CGTCGTCCTCGGAAACCATCACGGTGGGCCCGCTGGAGGTGGACATCCCCGGCCGGCGGGCCCGGGTCAACGGCGTCGAC
GTCGACCTGACCAAGCGCGAATTCGACCTGCTCGCGGTGCTGGCCGAGCACAAGACCGCGGTGCTCTCCCGAGCGCAACT
CCTGGAATTGGTGTGGGGCTACGACTTCGCCGCCGACACCAACGTGGTGGACGTCTTCATCGGGTACCTGCGGCGCAAAC
TGGAGGCCGGCGGMGGSCCTAGGCTGCTGCATACCGTCCGCGGAGTCGGATTCGTGCTGCGTATGCAGTGA

Protein sequence :
MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVXALRAMD
NDVPVCVLSARSSVDDRVAGLEAGADDYLVXPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVD
VDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 8e-25 42
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 3e-24 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA BAC0083 Protein 3e-30 46
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA BAC0125 Protein 6e-29 43
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA BAC0197 Protein 3e-24 43
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA AE000516.2.gene3505. Protein 4e-28 43
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA HE999704.1.gene1528. Protein 1e-30 42
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA BAC0638 Protein 2e-23 42
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_012469.1.7685629. Protein 3e-27 42
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA BAC0308 Protein 1e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_002952.2859905.p0 Protein 1e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_009641.5332272.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_013450.8614421.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_007793.3914279.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_003923.1003749.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_002745.1124361.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_007622.3794472.p0 Protein 1e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_009782.5559369.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_002951.3237708.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA NC_002758.1121668.p0 Protein 2e-26 41
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA HE999704.1.gene2815. Protein 2e-26 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA VFG1389 Protein 2e-86 99
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA VFG1390 Protein 1e-40 50
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA VFG1386 Protein 6e-36 45
I917_06355 YP_007957056.1 two component response transcriptional regulatory protein PRRA VFG0596 Protein 3e-25 42