Gene Information

Name : guaA (I917_23865)
Accession : YP_007959382.1
Strain : Mycobacterium tuberculosis Haarlem/NITR202
Genome accession: NC_021192
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : -
COG ID : -
EC number : 6.3.5.2
Position : 3804485 - 3806062 bp
Length : 1578 bp
Strand : -
Note : COG0518 GMP synthase - Glutamine amidotransferase domain

DNA sequence :
GTGGTGCAGCCTGCTGACATCGACGTGCCTGAGACACCGGCTCSKCCGGMGTTGGMGGMCGYCTTCGGTGCCCAATATGC
CCAGTTGATTGCCCGTCGGGTTCGAGAAGCACGGGTTTTCTCCGAGGTGATTCCGCACACCGCCTCGATCGAGGAGATCA
GGGCCCGTCAGCCGGTGGCGCTCGTGCTTTCCGGTGGACCGGCCAGTGTCTACGCCGACGGCGCTCCGAAACTCGATCCG
GCGCTACTGGACCTCGGTGTACCGGTTCTTGGCATCTGCTACGGGTTTCAGGCCATGGCGCAGGCGCTCGGGGGGATCGT
CGCCCACACCGGCACTCGCGAATACGGTCGGACTGAACTGAAAGTCCTTGGTGGCAAACTGCATTCGGATCTTCCCGAGG
TTCAGCCGGTATGGATGAGTCACGGTGACGCGGTCACGGCCGCGCCGGACGGATTCGACGTGGTGGCTAGCAGCGCCGGT
GCCCCGGTGGCCGCCTTCGAGGCCTTCGACCGGCGCCTGGCCGGGGTGCAGTATCACCCGGAGGTGATGCACACCCCACA
CGGGCAACAGGTGCTCAGCCGGTTTTTGCACGACTTCGCCGGGCTCGGCGCCCAGTGGACGCCCGCCAACATCGCCAACG
CGCTGATCGAGCAGGTGCGCACCCAGATCGGCGACGGCCACGCCATCTGCGGGCTATCCGGCGGCGTGGATTCCGCGGTG
GCCGCGGCCCTGGTGCAGCGGGCCATCGGCGACCGGTTGACCTGTGTCTTCGTCGACCACGGGCTGTTGCGCGCCGGTGA
GCGGGCGCAGGTGCAACGCGATTTCGTGGCCGCCACCGGCGCCAACCTGGTCACCGTCGACGCGGCCGAGACCTTCCTCG
AGGCGCTGTCGGGCGTGAGCGCCCCCGAGGGCAAACGCAAGATCATCGGCCGTCAGTTCATCCGCGCGTTCGAGGGCGCG
GTGCGGGATGTGCTGGACGGTAAGACTGCTGAGTTCCTGGTGCAGGGCACGCTGTATCCGGATGTGGTGGAGTCCGGCGG
GGGCAGCGGCACCGCGAACATCAAGAGCCACCACAATGTCGGCGGCCTGCCCGACGACCTGAAGTTCACCCTCGTTGAGC
CGCTGCGGCTGCTGTTCAAAGACGAGGTGCGCGCGGTCGGGCGGGAGTTGGGTCTGCCGGAGGAGATCGTGGCGCGCCAG
CCGTTTCCGGGACCGGGGTTGGGTATTCGGATCGTCGGGGAGGTCACCGCCAAGCGGGTGGATACGCTGCGGCACGCCGA
TTCGATCGTGCGTGAGGAGCTGACCGCGGCGGGSCTGGACAACCAGATCTGGCAGTGTCCGGTGGTGCTGTTGGCCGATG
TCCGCTCGGTGGGTGTGCAGGGTGACGGTCGCACCTATGGCCACCCGATTGTGCTGCGTCCGGTGTCGAGTGAAGACGCG
ATGACCGCCGACTGGACCCGGGTGCCCTACGAGGTGCTCGAGCGCATCTCGACCCGGATCACCAACGAGGTCGCCGAGGT
CAACCGCGTGGTGCTGGACATCACCAGCAAGCCSCCCGCCACCATCGAGTGGGAGTAG

Protein sequence :
MVQPADIDVPETPAXPXLXXXFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVYADGAPKLDP
ALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAG
APVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAV
AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGA
VRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQ
PFPGPGLGIRIVGEVTAKRVDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDA
MTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 77
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-128 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-128 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-129 51