Gene Information

Name : I917_16785 (I917_16785)
Accession : YP_007958424.1
Strain : Mycobacterium tuberculosis Haarlem/NITR202
Genome accession: NC_021192
Putative virulence/resistance : Virulence
Product : bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2674018 - 2675268 bp
Length : 1251 bp
Strand : +
Note : COG1021 Peptide arylation enzymes

DNA sequence :
ATGTGGCSAKCTGGGKTCGACTATCGGCCGATGGCGCGCGAACTTGTTGCCGATCACCCCACCCTGCGCCATGTCATCGT
CGATGGCGATCCGGGACCGTTCGTGTCGTGGGCGCAGCTGTGCGCCCAGGCCGGCACCGGTTCGCCGGCACCGCCGGCCG
ATCCCGGATCGCCAGCGCTGCTGCTGGTCTCCGGCGGCACYACTGGCATGCCCAAACTCATTCCACGCACCCACGACGAC
TACGTGTTCAACGCGACGGCCAGCGCCGCACTCTGTCGGCTTAGCGCCGACGACGTCTATCTGGTGGTGCTGGCCGCCGG
CCACAATTTCCCGCTGGCCTGCCCGGGCCTGCTCGGCGCGATGACCGTCGGGGCCACCGCCGTGTTCGCCCCCGATCCCA
GCCCGGAGGCCGCCTTCGCCGCCATCGAGCGCCACGGTGTCACCGTCACCGCGTTGGTTCCGGCACTGGCCAAACTGTGG
GCCCAATCCTGTGAGTGGGAGCCGGTGACACCGAAGTCACTGCGGTTGTTGCAGGTTGGCGGGTCCAAGCTAGAACCCGA
GGACGCTCGCCGGGTACGCACCGCGCTCACCCCGGGCCTGCAGCAGGTGTTCGGCATGGCGGAGGGGCTGSTGAACTTCA
CCCGCATCGGCGACCCACCCGAAGTGGTGGAGCACACCCAGGGGCGGCCACTATGCCCGGCCGACGAACTGCGCATCGTC
AACGCCGATGGTGAGCCGGTGGGGCCCGGGGAGGAAGGCGAACTCTTGGTGCGCGGGCCCTACACGCTGAACGGCTATTT
TGCTGCCGAACGCGACAACGAGCGCTGCTTCGATCCGGACGGCTTCTACCGCAGCGGCGACCTGGTCCGCCGCCGCGACG
ACGGCAATCTGGTGGTCACCGGGCGCGTCAAGGATGTCATCTGCCGTGCGGGAGAAACCATCGCCGCCAGCGACCTCGAA
GAACAGCTGCTGAGCCATCCGGCGATCTTCTCGGCCGCGGCGGYGGGACTACCTGACCAGTATCTGGGGGAAAWRATCTG
CGCTRCAGTCGTTTTYGCTRGAGCTCCGATTACGCTTGCGGAGTTGAACGGCTACCTTGACCGGCGTGGTGTGGCCGCGC
ATACGCGACCCGACCAGCTGGTCGCGATGCCGGCGCTGCCCACAACGCCGATCGGGAAGATCGACAAACGAGCGATCGTC
CGCCAGCTCGGCATCGCGACGGGTCCCGTGACGACCCAGCGCTGCCATTGA

Protein sequence :
MWXXGXDYRPMARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDD
YVFNATASAALCRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLW
AQSCEWEPVTPKSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLXNFTRIGDPPEVVEHTQGRPLCPADELRIV
NADGEPVGPGEEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLE
EQLLSHPAIFSAAAXGLPDQYLGEXICAXVVFAXAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIV
RQLGIATGPVTTQRCH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 6e-70 47
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-70 47
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-70 47
ybtE CAA21394.1 - Virulence HPI Protein 6e-70 47
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-70 47
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 4e-70 47
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-70 47
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 7e-70 47
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-70 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
I917_16785 YP_007958424.1 bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase VFG1817 Protein 1e-170 99
I917_16785 YP_007958424.1 bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase VFG0168 Protein 2e-68 47