Gene Information

Name : Desgi_1749 (Desgi_1749)
Accession : YP_007944883.1
Strain : Desulfotomaculum gibsoniae DSM 7213
Genome accession: NC_021184
Putative virulence/resistance : Resistance
Product : D-alanine--D-alanine ligase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1787424 - 1788479 bp
Length : 1056 bp
Strand : +
Note : PFAM: D-ala D-ala ligase C-terminus; D-ala D-ala ligase N-terminus; TIGRFAM: D-alanine--D-alanine ligase

DNA sequence :
ATGAAAAATGAAAAAAACAAAGTTGCCGTTTTATTCGGCGGATGCTCTACAGAGTATGAGGTTTCTCTCCAATCCGCCTA
TTCTGTAATAACGAACCTAAATCCAAATAAGTATGAAACCATATTGATTGGAATCACTCGGCAGGGAGCTTGGTTGAGAT
ATTATGGCTCACTTGAAAAAATTCAGAATGACACATGGATGGATAGCAACGATTGTGTCCCAGCAATCATTTCACCTGAT
CGGAATATTCACGGACTGCTCGAATTTCGTGGTAATAAAGTGATTGCAACCAGAATTGATGTGGCGTTTCCTGTTCTGCA
TGGAAAAAACGGCGAGGACGGAACATTACAGGGATTATTAACGATAGCTGGTATTCCTTTTGCAGGGTGTGGTACGCTTT
GTTCTGCAATGTGCATGGACAAGGACATCGCTCACAAAATAGCAAATCTGGCCGGTATCAAAACACCTCCGTCCGTCGTG
CTGCGGTCCGGATTTACCGATGCCGAACTGATGAAGCAGATTAGCTACCTAACATTTCCTCTGTTTGTTAAACCGGCAAA
CGCCGGTTCCTCATTTGGTATTACAAAGGTTTTGCAAAAGGATGAGCTTTCCGATGCAGTCACCGTTGCTTTTCAACATG
ACAATAAGGTCATCATAGAGGAAGCCGTCGACGGTTTTGAGGTTGGCTGTGCCGTCCTTGGCAATGATTCGCTTGCCATC
GGTGAGGTTGACGAAATAGAGCTGTCTCATGGGTTCTTTGATTACACGGAGAAATATACCCTGAAAACCTCTAAAATCCA
TATGCCTGCCCGCATTGATCCAGATACAGCCGAGCGTATTAAACAGACGGCTTCCGTCATTTACCGGGCGCTCGATTGCT
CGGGATTTGCAAGGGTTGATTTGTTTCTGACACCGGAAAAAGAAATCATCTTCAACGAAGTAAATACAATTCCCGGTTTT
ACCTCTCACAGCCGCTATCCCAATATGCTAAAAGGCATTGGAATGACATTCGGGCAGATTGTGGATGCAGCGATAAGTCT
GGCGACAAACTCATGA

Protein sequence :
MKNEKNKVAVLFGGCSTEYEVSLQSAYSVITNLNPNKYETILIGITRQGAWLRYYGSLEKIQNDTWMDSNDCVPAIISPD
RNIHGLLEFRGNKVIATRIDVAFPVLHGKNGEDGTLQGLLTIAGIPFAGCGTLCSAMCMDKDIAHKIANLAGIKTPPSVV
LRSGFTDAELMKQISYLTFPLFVKPANAGSSFGITKVLQKDELSDAVTVAFQHDNKVIIEEAVDGFEVGCAVLGNDSLAI
GEVDEIELSHGFFDYTEKYTLKTSKIHMPARIDPDTAERIKQTASVIYRALDCSGFARVDLFLTPEKEIIFNEVNTIPGF
TSHSRYPNMLKGIGMTFGQIVDAAISLATNS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 5e-68 47
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 1e-68 46

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase U00456.gene.p01 Protein 3e-68 47
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase U35369.1.gene6.p01 Protein 3e-68 47
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase AE016830.1.gene2250. Protein 3e-68 47
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase AY489045.gene.p01 Protein 2e-65 47
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase AF277571.gene.p01 Protein 5e-67 47
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase AY145441.gene.p01 Protein 3e-69 46
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase AF310956.2.orf5.gene Protein 7e-69 46
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase NC_005054.2598280.p0 Protein 3e-65 44
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase NC_014475.1.orf3.gen Protein 3e-65 44
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase AF130997.1.orf4.gene Protein 6e-63 44
Desgi_1749 YP_007944883.1 D-alanine--D-alanine ligase AF162694.gene.p01 Protein 9e-69 43