Gene Information

Name : SFUL_5226 (SFUL_5226)
Accession : YP_007934004.1
Strain : Streptomyces fulvissimus DSM 40593
Genome accession: NC_021177
Putative virulence/resistance : Virulence
Product : Pyruvate kinase
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.1.40
Position : 5771662 - 5773089 bp
Length : 1428 bp
Strand : -
Note : UniProt-pubmed:11572948; UniProt-pubmed:20624727; UniProt-pubmed:20064060; gene_name:pykA1; pathway_coverage:02.01.02.01 standard path; UniProt-pubmed:21463507; gene_name:pyk2; pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3

DNA sequence :
ATGCGCCGTTCCAAAATCGTCTGCACCCTCGGTCCCGCCGTCGACTCCCATGAGCAGCTCGTCGCTCTGATCGAGGCCGG
CATGAGCGTGGCCCGTTTCAACTTCAGTCACGGCACCCACGAGGAACACCAGGGCCGGTACGACCGTGTCCGCAAGGCGG
CCGCCGAGACCGGCCGCGCGGTGGGCGTCCTCGCCGACCTCCAGGGCCCGAAGATCCGCCTGGCCAAGTTCGCCGAGGGC
CCGGTCGAGCTGGTCCGCGGGGACGAGTTCACCATCACGTCCGAGGACGTCCCCGGCGACAAGTCGATCTGCGGCACGAC
CTACAAGGGTCTGCCCGGCGACGTCACCAAGGGCGACCCGATCCTGATCAACGACGGCAACGTCGAGCTGAAGGTCATCG
AGGTCGTCGGCCCCCGGGTCAAGACCATCGTCATCGAGGGCGGTGTCATCTCCGACCACAAGGGCATCAACCTGCCCGGC
GCGGCGGTGAACGTCCCGGCCCTCTCCGAGAAGGACATCGAGGACCTGCGCTTCGCCCTGCGGATGGGCTGCGACCTGGT
CGCCCTCTCCTTCGTCCGGGACGCCGACGACGTCAAGGACGTGCACAAGGTGATGGACGAGGAGGGCCGCCGGGTCCCCG
TCATCGCCAAGGTGGAGAAGCCGCAGGCGGTCGAGCACATGGAGGGCGTCGTCATGGCGTTCGACGGTGTGATGGTGGCC
CGTGGCGACCTGGCGGTGGAGTACCCGCTGGAGAAGGTCCCGATGGTGCAGAAGCGCCTCATCGAGCTGTGCCGCCGCAA
CGCCAAGCCGGTGATCGTGGCGACCCAGATGATGGAGTCGATGATCACCAACTCGCGGCCGACCCGCGCCGAGGCGTCCG
ACGTCGCGAACGCGATCCTGGACGGCGCGGACGCGGTCATGCTGTCCGCCGAGTCGTCGGTGGGCGCGTACCCGATCGAG
ACGGTCAAGACGATGTCGAAGATCGTCTGCGCCGCCGAGGAGGAGCTGCTCTCCAAGGGCCTCCAGCCGCTGGTGCCCGG
CAAGAAGCCCCGTACCCAGGGCGGTTCGGTGGCCCGTGCGGCCTGCGAGATCGCGGACTTCCTGGACGGCAAGGCCCTGG
TCGCCTTCACCCAGTCCGGCGACACCGCCCGCCGCCTCTCCCGCTACCGCGTGGCCCAGCCGATCCTGGCCTTCACCACG
GACGAGTCCACCCGCAACCAGCTCGCGCTGAGCTGGGGCGTCGAGTCGCACGTCGTCCCTCACGCGGACAACACCGACGC
GATGGTCGACCTGGTCGACGCGGAGCTGCTGAAGCTGAACCGCTACAACACCGGCGACACGATGATCATCACCGCCGGTT
CGCCCCCCGGCATCCCCGGCACCACCAACATGGTCCGGGTCCACCACCTGGGCGGCGAGCAGGGCTAG

Protein sequence :
MRRSKIVCTLGPAVDSHEQLVALIEAGMSVARFNFSHGTHEEHQGRYDRVRKAAAETGRAVGVLADLQGPKIRLAKFAEG
PVELVRGDEFTITSEDVPGDKSICGTTYKGLPGDVTKGDPILINDGNVELKVIEVVGPRVKTIVIEGGVISDHKGINLPG
AAVNVPALSEKDIEDLRFALRMGCDLVALSFVRDADDVKDVHKVMDEEGRRVPVIAKVEKPQAVEHMEGVVMAFDGVMVA
RGDLAVEYPLEKVPMVQKRLIELCRRNAKPVIVATQMMESMITNSRPTRAEASDVANAILDGADAVMLSAESSVGAYPIE
TVKTMSKIVCAAEEELLSKGLQPLVPGKKPRTQGGSVARAACEIADFLDGKALVAFTQSGDTARRLSRYRVAQPILAFTT
DESTRNQLALSWGVESHVVPHADNTDAMVDLVDAELLKLNRYNTGDTMIITAGSPPGIPGTTNMVRVHHLGGEQG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 3e-79 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-79 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-79 42
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 2e-70 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 6e-79 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SFUL_5226 YP_007934004.1 Pyruvate kinase VFG0479 Protein 5e-80 42