Gene Information

Name : SFUL_4752 (SFUL_4752)
Accession : YP_007933533.1
Strain : Streptomyces fulvissimus DSM 40593
Genome accession: NC_021177
Putative virulence/resistance : Resistance
Product : Cystathionine gamma-synthase
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 5251747 - 5252892 bp
Length : 1146 bp
Strand : +
Note : pathway_coverage:01.01.62.12 degradation of methionine to 2-oxobutanoate (cysteine biosynthesis in animals); UniProt-pubmed:11572948; pathway_coverage:01.01.15.15 biosynthesis of cysteine by transsulfuration (animals and microorganisms); cofactor:Pyridoxa

DNA sequence :
ATGAGCGACCAGCACAGCTTCGAGACTCTCGCGATCCACGCGGGGAACACCGCCGACCCCCTCACCGGCGCGGTGGTTCC
GCCCATCTACCAGGTGTCCACGTACAAGCAGGACGGCGTGGGCGGACTGCGCGGCGGCTACGAGTACAGCCGCAGCGCCA
ACCCCACCCGTACCGCCCTGGAGGAGAACCTGGCGGCCCTGGAAGGCGGCCGCCGCGGTCTCGCCTTCGCCTCCGGCCTC
GCCGCCGAGGACTGCCTCCTGCGTACGCTGCTGACCCCCGGTGACCACGTGGTCATCCCCAACGACGCCTACGGCGGCAC
CTTCCGGCTGTTCGCGAAGGTCGCCGCGCGCTGGGGCGTGGAGTTCTCGGTCGCCGACACCTCGGACGTGGCGGCGGTGC
GGGCGGCGATCACCCCGCGCACCAAGGCGGTCTGGGTGGAGACCCCCTCCAACCCGCTGCTCAACATCACCGACATCGCC
GCCGTCGCCCAGGTCGCGCACCAGGCCGGGGCCCGCCTCGTCGTCGACAACACCTTCGCCTCGCCCTACCTCCAGCAGCC
GCTGCCCCTCGGCGCGGACGTCATCGTGCACTCCACCACCAAGTACATGGGCGGCCACTCCGACGTCGTCGGCGGCGCCC
TCGTCGTCAGCGACCCGGAGCTTGCCGAGGAGCTGGCGTTCCACCAGAACGCCATGGGCGCGGTCTCCGGCCCCTTCGAC
GCCTGGCTCGTGCTGCGCGGCATCAAGACCCTCGCCGTCCGCATGGACCGGCACACCGAGAACGCCACCAAGGTCACCGA
GCTGCTGACCCGGCACCCCAAGGTCTCCCAGGTCCTCTACCCGGGCCTGCCCGAGCACCCCGGCCACGAGGTCGCCGCCA
AGCAGATGAAGGCCTTCGGCGGCATGGTGTCCTTCCGCGTCAACGGCGGCGAGGAGGCGGCTGTCGAGGTCTGCAACCGG
GCGAAGCTCTTCACGCTCGGTGAGTCCCTCGGCGGCGTCGAGTCGCTGATCGAGCACCCCGGCCGGATGACGCACGCCTC
CGTCGCGGGCTCCCTGCTGGAGGTCCCCGCCGACCTGGTCCGTCTCTCCGTCGGCATCGAGAACGGCGACGACCTGCTCG
CCGACCTCACCCAGGCCCTGGGCTGA

Protein sequence :
MSDQHSFETLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALEGGRRGLAFASGL
AAEDCLLRTLLTPGDHVVIPNDAYGGTFRLFAKVAARWGVEFSVADTSDVAAVRAAITPRTKAVWVETPSNPLLNITDIA
AVAQVAHQAGARLVVDNTFASPYLQQPLPLGADVIVHSTTKYMGGHSDVVGGALVVSDPELAEELAFHQNAMGAVSGPFD
AWLVLRGIKTLAVRMDRHTENATKVTELLTRHPKVSQVLYPGLPEHPGHEVAAKQMKAFGGMVSFRVNGGEEAAVEVCNR
AKLFTLGESLGGVESLIEHPGRMTHASVAGSLLEVPADLVRLSVGIENGDDLLADLTQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-79 48
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-80 48
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 9e-61 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SFUL_4752 YP_007933533.1 Cystathionine gamma-synthase BAC0207 Protein 2e-63 45