Gene Information

Name : J112_12790 (J112_12790)
Accession : YP_007855379.1
Strain : Mycobacterium tuberculosis Beijing/NITR203
Genome accession: NC_021054
Putative virulence/resistance : Virulence
Product : bifunctional salicyl-AMP ligase/salicyl-S-arcpsynthetase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2675714 - 2677396 bp
Length : 1683 bp
Strand : +
Note : COG1021 Peptide arylation enzymes

DNA sequence : 
ATGCCACCGAAGGCGGCAGATGGCCGCCGACCCAGTCCCGACGGCGGACTGGGTGGCTTTGTACCGTTCCCCGCGGATCG
GGCCGCGTCGTACCGGGCGGCCGGCTATTGGTCGGGGCGAACCCTGGACACCGTGCTCTCCGATGCCGCGCGGCGCTGGC
CTGACCGCCTCGCGGTGGCCGACGCGGAGATGCACGACGAGGTGGGTTTGCGGAATCAGCGGGCCGACCGGGAAGCTGAA
GTCGAGCAGGCCCTGGGCATCACGCCAGGCGACCGGGTACTGCTCCAGCTGCCAAACGGCTGCCAGTTCGCGGTTGCCCT
GTTCGCGTTATTGCGGGCGGGAGCGATCCCAGTGATGTGCCTGCCCGGTCACCGCGCCGCCGAATTGGGCCACTTCGCCG
CCGTCAGCGCGGCCACCGGGCTGGTGGTCGCCGATGTGGCCAGCGGGTTCGACTATCGGCCGATGGCGCGCGAACTTGTT
GCCGATCACCCCACCCTGCGCCATGTCATCGTCGATGGCGATCCGGGACCGTTCGTGTCGTGGGCGCAGCTGTGCGCCCA
GGCCGGCACCGGTTCGCCGGCACCGCCGGCCGATCCCGGATCGCCAGCGCTGCTGCTGGTCTCCGGCGGCACCACTGGCA
TGCCCAAACTCATTCCACGCACCCACGACGACTACGTGTTCAACGCGACGGCCAGCGCCGCACTCTGTCGGCTTAGCGCC
GACGACGTCTATCTGGTGGTGCTGGCCGCCGGCCACAATTTCCCGCTGGCCTGCCCGGGCCTGCTCGGCGCGATGACCGT
CGGGGCCACCGCCGTGTTCGCCCCCGATCCCAGCCCGGAGGCCGCCTTCGCCGCCATCGAGCGCCACGGTGTCACCGTCA
CCGCGTTGGTTCCGGCACTGGCCAAACTGTGGGCCCAATCCTGTGAGTGGGAGCCGGTGACACCGAAGTCACTGCGGTTG
TTGCAGGTTGGCGGGTCCAAGCTAGAACCCGAGGACGCTCGCCGGGTACGCACCGCGCTCACCCCGGGCCTGCAGCAGGT
GTTCGGCATGGCGGAGGGGCTGCTGAACTTCACCCGCATCGGCGACCCACCCGAAGTGGTGGAGCACACCCAGGGGCGGC
CACTATGCCCGGCCGACGAACTGCGCATCGTCAACGCCGATGGTGAGCCGGTGGGGCCCGGGGAGGAAGGCGAACTCTTG
GTGCGCGGGCCCTACACGCTGAACGGCTATTTTGCTGCCGAACGCGACAACGAGCGCTGCTTCGATCCGGACGGCTTCTA
CCGCAGCGGCGACCTGGTCCGCCGCCGCGACGACGGCAATCTGGTGGTCACCGGGCGCGTCAAGGATGTCATCTGCCGTG
CGGGAGAAACCATCGCCGCCAGCGACCTCGAAGAACAGCTGCTGAGCCATCCGGCGATCTTCTCGGCCGCGGCGGTGGGA
CTACCTGACCAGTATCTGGGGGAAAAAATCTGCGCTGCAGTCGTTTTCGCTGGAGCTCCGATTACGCTTGCGGAGTTGAA
CGGCTACCTTGACCGGCGTGGTGTGGCCGCGCATACGCGACCCGACCAGCTGGTCGCGATGCCGGCGCTGCCCACAACGC
CGATCGGGAAGATCGACAAACGAGCGATCGTCCGCCAGCTCGGCATCGCGACGGGTCCCGTGACGACCCAGCGCTGCCAT
TGA

Protein sequence : 
MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAEMHDEVGLRNQRADREAE
VEQALGITPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPMARELV
ADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAALCRLSA
DDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTPKSLRL
LQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGEEGELL
VRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAAAVG
LPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-85 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 3e-85 44
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 8e-84 43
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-84 43
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-84 43
ybtE CAA21394.1 - Virulence HPI Protein 8e-84 43
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 6e-84 43
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 8e-84 43
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-84 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
J112_12790 YP_007855379.1 bifunctional salicyl-AMP ligase/salicyl-S-arcpsynthetase VFG1817 Protein 0.0 97
J112_12790 YP_007855379.1 bifunctional salicyl-AMP ligase/salicyl-S-arcpsynthetase VFG0168 Protein 8e-86 45