Gene Information

Name : LPE509_01108 (LPE509_01108)
Accession : YP_007567651.1
Strain : Legionella pneumophila Philadelphia 1
Genome accession: NC_020521
Putative virulence/resistance : Resistance
Product : Lead, cadmium, zinc and mercury transporting ATPase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1162838 - 1164991 bp
Length : 2154 bp
Strand : +
Note : FIG00658111

DNA sequence :
ATGACAACGCCTTTAAGGTTAACAACGTTTTTTGTGGCAGGACTGGATTGTCCTGCAGAAGAGCAACTGATTCGACGACA
ATTACAGGGCATTCCTGAAATTGAACATTTGGATTTTAATTTCATTGCTGAAGAAGTGACTATTCACCATCGTCTTTCTT
CCATAGATTTGTTGCAACAACGTATTGCAGCATTAGGAATGAGTGTGCGTTCTAAAAGCGGCATCCATCCAGCAAAAGAA
GGAGGGAGGTCTCTTTCTGATTCGTCTTGGCTACTCATTATTTTAGCTGGTGTTTTCGCTCTTTTTTCCGAATTGGCGGC
TTATTTTTTAGGCACAGAGCAATCCACCTGGAGTATTATCCCTGCCTTATTGGCTATGGTCTTAAGTGGTTCACCTACTT
TCAAAAAAGGTTGGCTTGCTTTGCGCACCAAAGCCATGAATATTAACAGTTTGATGTTGATTGCAATCAGTGGTGCTGTA
TTGATAGGCGAGTGGCCTGAGGCTGCGATGGTTACCGTGTTGTTTGCTTTGGCTGAGCGTATCGAGCGTTATTCGTTAGA
TAAAGCGCGATTAGCTATTCGAAGTTTGATGCAAATTGCTCCGGAAGTGGCTCGAGTTAAAATGGACAATGGTCAATGGC
AAACCATGCCGGTAGAAGAGGTACCACTAGAGGCTGTTTTCAGGGTAAGGCCGGGTGAGCGAATTCCCTTGGATGGAGTA
GTGATTTCGGGGCAAAGTACCGTCAATCAAGCGCCGATTACAGGTGAGTCCATGCCAGTAGTCAAACAAGTAGGGGATGA
GGTTTTTGCAGGTAGTTTAAATGAGCATGGTGCTTTTGAGGTCCAGGTCACAAAAGCATCAGGAGATACGCTGCTTGCTA
AAATTGGTAAGGCCATTGAACAAGCGCAGGCTGAACGGGCGCCAACTCAACGTTTTGTGGACCAATTTGCCAAGTATTAC
ACACCCATCATGGTCTTGATAGCAGTTCTTATTGCACTGTTCCCTCCATTGGCATTGGGTTATCCTTTTTATGACTGGCT
CTATAAGGCGTTAACTTTGCTGGTGATTGCTTGCCCTTGTGCTTTAGTCATTTCAACGCCGGTGACCGTTGTGAGTGGAT
TGGCTGCTGCTGCAAAACATGGACTTCTTATTAAGGGAGGGAGCTATTTAGAGACAGGTTATCGATTAAAATTAATCGCA
TTGGATAAAACAGGTACTTTAACAGAAGGCAAACCAATTGTGACTGATTTTATTGTTTATGATAAGAGCCAAACCAAAGA
GCAACTGTTATTGTTGGCTGCAAGCCTGGATAGTCACTCCGAACATCCTGTGGCTCATGCTTTAGTGACGTATTGGCAAC
AAGAACAATCCAATAGTTCCTTGCTGGATGTGGAGGAATTCTTTGCTCTTCCTGGGCGAGGTGTGAAAGGACTGGTTCAG
CAAGAACTTTATTACATAGGCAATCATCAATTGGCTGAAGACAATCAAGTCTGTAATTCTGCGATAGAACAAGCACTCAA
ACGATTAGAAGAGGAAGGAAAAACCACCGTTATCTTAAGCAACAGCTCCACTGTATTGGCTGTTTTTGCAGTCGCCGACA
CGCTTCGCACAACCAGCCAATGGGCGATTGCAAGGCTTCACCAACAAGGGATAAAAACAGCCATGTTAACAGGAGATAAT
GCGGTGACTGCTCATGCGATTGCCAAGCAAGTGGGTATTGATGAAGTGAAAGCGAATGTTTTGCCTACGGATAAACTCCA
GGCCATTGATTTTCTCATAGAGCAATATAAAGCGGTAGGAATGGTTGGTGATGGAATTAATGATGCGCCTGCTTTGGCCA
AAGCAACTGTTAGTTTTGCAATGGGCAAAGGAACAGATACCGCATTGGAAACAGCGGATGTGGCCTTGATGAATGACAAT
TTGGCGATGCTTCCTTTGTACATTGATTTAAGTCGCAACACAGCACGGATTCTTCGTCAAAACATTAGCTTATCCATTGC
AATCAAAGGGATTTTTTTCTTTTTGGCACTTGCGGGCATCGCAACTCTTTGGATGGCAGTGTTTGCAGACATGGGAGCGA
GTTTGATTGTGGTTGTGAATGGATTGCGATTATTGAATTCGCATCAAGGACATTCTGAAATTCAGGAAATATAG

Protein sequence :
MTTPLRLTTFFVAGLDCPAEEQLIRRQLQGIPEIEHLDFNFIAEEVTIHHRLSSIDLLQQRIAALGMSVRSKSGIHPAKE
GGRSLSDSSWLLIILAGVFALFSELAAYFLGTEQSTWSIIPALLAMVLSGSPTFKKGWLALRTKAMNINSLMLIAISGAV
LIGEWPEAAMVTVLFALAERIERYSLDKARLAIRSLMQIAPEVARVKMDNGQWQTMPVEEVPLEAVFRVRPGERIPLDGV
VISGQSTVNQAPITGESMPVVKQVGDEVFAGSLNEHGAFEVQVTKASGDTLLAKIGKAIEQAQAERAPTQRFVDQFAKYY
TPIMVLIAVLIALFPPLALGYPFYDWLYKALTLLVIACPCALVISTPVTVVSGLAAAAKHGLLIKGGSYLETGYRLKLIA
LDKTGTLTEGKPIVTDFIVYDKSQTKEQLLLLAASLDSHSEHPVAHALVTYWQQEQSNSSLLDVEEFFALPGRGVKGLVQ
QELYYIGNHQLAEDNQVCNSAIEQALKRLEEEGKTTVILSNSSTVLAVFAVADTLRTTSQWAIARLHQQGIKTAMLTGDN
AVTAHAIAKQVGIDEVKANVLPTDKLQAIDFLIEQYKAVGMVGDGINDAPALAKATVSFAMGKGTDTALETADVALMNDN
LAMLPLYIDLSRNTARILRQNISLSIAIKGIFFFLALAGIATLWMAVFADMGASLIVVVNGLRLLNSHQGHSEIQEI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 2e-162 52
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 4e-127 43
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 9e-124 42
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 9e-124 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
LPE509_01108 YP_007567651.1 Lead, cadmium, zinc and mercury transporting ATPase BAC0298 Protein 1e-157 53
LPE509_01108 YP_007567651.1 Lead, cadmium, zinc and mercury transporting ATPase BAC0092 Protein 4e-85 41
LPE509_01108 YP_007567651.1 Lead, cadmium, zinc and mercury transporting ATPase BAC0461 Protein 6e-79 41
LPE509_01108 YP_007567651.1 Lead, cadmium, zinc and mercury transporting ATPase BAC0124 Protein 7e-74 41