Gene Information

Name : cagA (HPOK113_0565)
Accession : YP_007536679.1
Strain : Helicobacter pylori OK113
Genome accession: NC_020508
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 597443 - 600991 bp
Length : 3549 bp
Strand : +
Note : -

DNA sequence : 
ATGACTAACGAAACCATTGATCAAACAACAACACCAGATCAAACACCAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTCTTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAGGAATTCGCTAATAAAGCGATCAAAAAT
CCTGCCAAAAAGAATCAGTATTTTTCAAACTTTATCAGTAAGAGCAATGATTTAATCGACAAAGACAGTCTCATTGATAT
AGGTTCTTCCATAAAGAGCTTTCAGAAATTTGGGACTCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAG
ATCCATCTAAAATCAACACCCAAAGAATCCGAAGTTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAAACTTTTGCAGGAATTATCATAGGAAACCAGATCCAATCAGATCAAAAATT
CATGGGCGTGTTTGAAGAATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTACTGGAGAGCCTACTGGTG
GGGATTGGCTTGATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTTAAAGAAACACTAAATCAAGAA
CCAGTTCCTCATGTCCAACCAGATATAGCCACTACCACCACTGACATACAAAGCTTACCGCCTGAAGCTAGGGATTTTCT
TGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGTGATATGGAAATGTTGGATGTTGAGGGCGTCGCTGATATTGATC
CTAATTACAAGTTCAACCAATTATTGATTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAA
CCTGAAAAAGTTTCATTATTGTATGGGGGCAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAA
AAACCAACAAGGCGACAATGTGGCTACACTCATTAATGTGCATATGAAAAACGGCAGTGGGTTAGTCATAGCAGGTGGTG
AGAAAGGGGTTAACAACCCTAGTTTTTATCTCTACAAAGAAGACCAGCTCACAGGCTTGAAACAAGCATTGAGCCAAGAA
GAGATCCAAAACAAAGTAGATTTCATGGAATTTCTTGCACAAAACAATGCTAAATTAGATAACTTGAGCAAGAAAGAGAA
AGAAAAATTCCAAAATGAGATTGAAGATTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTG
CTTTTGTTTCTAAAAAAGACAAAAAACATTTAGCTTTAGTTGCTGAGTTTGGTAATGGGGAATTGAGCTACACTCTCAAA
GATTATGGGAAAAAACAAGATAAAGCTTTAGATAGGGAGACAAAAACCACTCTTCAAGGTAACCTAAAACATGATGGCGT
GATGTTTGTTAATTATTCTAATTTCAAATACACCAACGTCTCCAAGAGTCCTGATAAGGGTGTAGGCACTACGAATGGCG
TTTCCCATTTGGAAGCAAATTTTAGCAAGGTAGCTGTTTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTAT
ATAAGGCGAGATTTAGAAGATAAACTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTT
GAACAGCAACAAAGAATTGGTTGAAAAAGCTTTAAACTTCAATAAAACTGTAGCTGAAGCTAAAAACACAGGCAATTATG
ACGAAGTGAAAAAAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAACGAAAAAA
TTGGAGAGCAGAAACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACT
TATCAATCAAGAGGCTAGTAAGGAAGCAAGAGCGGTCGCTTTCGATCAGAATCTTAAAAGCATCAGGAGCGAATTGTTTG
ATAAACTTGAAAATATCAACAAGAATTTGAAAAACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGAT
TTCAGCAAGGCAGAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAA
AGTTGAAAACCTTAATACAGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAA
GCGACCTTGAAAATTCCATTAAAGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAAGCTGTA
TCAATAGCTAAAGCAACGAGTGATTTCAGTAGGGTAGAGCAAGCGCTAGCCGAACTCAAAAACTTGTCATTGGATCTTGG
AAAAAATTCTGATCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAG
CCACAACGCTCACCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAAT
AATGGACTCAAAAACAGCACAGAGCCTATTTACGCTAAAGTTAATAAAAAGAAAACAGGACAAGCAGCTAGCCCTGAAGA
GCCTATTTACGCTCAAGTTGCCAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATTAGCAATAAATAGAA
AAATTGACCGGATTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCT
GAACCCATTTACGCTACAATTGATTTTGATGAGGCAAATCAAGCAGGCTTCCCTTTGAGAAGAAGTGCTGCAGTTAATGA
TCTCAGTAAAGTAGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTGGCAATCTCAATCAGGCGGTATCAGAAGCTA
AAACATGTCATTTTGACAACCTAGATCAAATGATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATGAATCTATAT
GTTGAAAGTGCAAAAAAAGTGCCTACTAGTTTGTCAGCGAAATTGGACGATTATGCTACTAACAGCCACACACGCATTAA
TAGCAATGTCAAAAATGGAGCAATCAATGAAAAAGCGACTGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCG
TGAATGATAAGATAGTTGCGCATAATGTGGGAAGCGTTTCTTTGTCAGAGTATGATAAAATTGGCTTCAACCAGAAGAAT
ATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCTATAAAAGACATTAAGTCTGGCTTTGTGCA
ATTTTTAACCAATACATTTTCTACAGCATCTTATTACTGCTTGGCGGAAGAAAATGCGAAGCATGGAATCAAAAATGCTA
ATACAAAAGGTGGTTTCCAAAAATCTTAA

Protein sequence : 
MTNETIDQTTTPDQTPNQTDFVPQRFINNLQVAFLKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEFANKAIKN
PAKKNQYFSNFISKSNDLIDKDSLIDIGSSIKSFQKFGTQRYQIFMNWVSHQKDPSKINTQRIRSFMENIIQPPISDDKE
KAEFLRSAKQTFAGIIIGNQIQSDQKFMGVFEESLKERQEAEKNGEPTGEPTGGDWLDIFLSFVFNKKQSSDLKETLNQE
PVPHVQPDIATTTTDIQSLPPEARDFLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIE
PEKVSLLYGGNGGPEARHDWNATVGYKNQQGDNVATLINVHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGLKQALSQE
EIQNKVDFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGELSYTLK
DYGKKQDKALDRETKTTLQGNLKHDGVMFVNYSNFKYTNVSKSPDKGVGTTNGVSHLEANFSKVAVFNLPNLNNLAITNY
IRRDLEDKLLAKGLSPQEANKLIKDFLNSNKELVEKALNFNKTVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVTKK
LESRNDNKNRMEAKAQANSQKDKIFALINQEASKEARAVAFDQNLKSIRSELFDKLENINKNLKNFGKSFDELKNGKNND
FSKAEETLKALKDSVKDLGINPEWISKVENLNTALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAV
SIAKATSDFSRVEQALAELKNLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNN
NGLKNSTEPIYAKVNKKKTGQAASPEEPIYAQVAKKVSAKIDQLNEATLAINRKIDRINKIASAGKGVGGFSGAGRSASP
EPIYATIDFDEANQAGFPLRRSAAVNDLSKVGLSREQELTRRIGNLNQAVSEAKTCHFDNLDQMIDKLKDSTKKNVMNLY
VESAKKVPTSLSAKLDDYATNSHTRINSNVKNGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSVSLSEYDKIGFNQKN
MKDYSDSFKFSTKLNNAIKDIKSGFVQFLTNTFSTASYYCLAEENAKHGIKNANTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 90
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 90
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 90
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 90
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 90
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 90
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 89
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 89
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 89
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 89
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 89
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 89
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 88
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 88
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 88
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 88
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 88
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 87
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 87
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 87
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 87
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 87
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 87
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 86
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 86
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 86
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 86
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 85
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 85
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 85
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 83
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 81
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 81
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 81
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 80
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 80
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 79
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 79
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 79
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 77

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_007536679.1 cag pathogenicity island protein VFG0306 Protein 0.0 81