Gene Information

Name : mccB (BSU6051_27250)
Accession : YP_007534710.1
Strain : Bacillus subtilis 6051-HGW
Genome accession: NC_020507
Putative virulence/resistance : Resistance
Product : cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway MccB
Function : -
COG functional category : -
COG ID : -
EC number : 4.4.1.-
Position : 2784983 - 2786122 bp
Length : 1140 bp
Strand : -
Note : Evidence 1a: Function experimentally demonstrated in the studied strain; PubMedId: 10939241, 17056751; Product type e: enzyme

DNA sequence :
ATGAAGAAAAAAACATTGATGATACATGGCGGAATCACAGGTGATGAGAAAACAGGCGCAGTTTCCGTGCCGATTTATCA
AGTAAGCACGTACAAGCAGCCGAAAGCAGGGCAGCATACAGGCTACGAGTATTCAAGAACGGCCAATCCGACTCGAACCG
CTCTCGAAGCACTTGTGACAGAACTGGAAAGCGGGGAAGCAGGCTATGCGTTCAGCTCAGGAATGGCTGCCATTACAGCG
GTTATGATGCTGTTTAACAGCGGAGATCATGTCGTGTTGACTGATGATGTGTACGGCGGAACATATCGCGTGATGACAAA
GGTGCTTAACCGTCTTGGCATTGAATCAACATTTGTTGATACGAGCAGCAGGGAAGAAGTTGAAAAAGCGATTCGCCCTA
ATACAAAAGCAATTTATATTGAAACACCGACAAACCCGTTGCTCAAAATCACCGACCTGACGCTCATGGCTGATATCGCA
AAAAAAGCGGGTGTTCTGCTTATCGTAGACAATACCTTTAATACTCCTTATTTTCAACAGCCGCTTACTTTAGGCGCTGA
TATCGTACTGCACAGTGCGACAAAATATCTTGGCGGACACAGTGATGTCGTCGGAGGTTTAGTTGTGACAGCTTCGAAAG
AGCTTGGAGAAGAGCTGCATTTTGTGCAAAACTCCACAGGCGGCGTGCTCGGCCCTCAAGATTCCTGGCTGTTAATGAGA
GGAATCAAAACGTTGGGACTCAGAATGGAAGCGATCGATCAAAATGCGCGGAAAATCGCAAGCTTTCTTGAGAATCACCC
TGCTGTCCAAACGTTATATTACCCTGGTTCTTCAAATCATCCCGGACATGAGCTTGCAAAAACGCAAGGAGCGGGCTTCG
GCGGCATGATCTCCTTTGATATTGGCAGTGAAGAACGGGTTGATGCGTTTTTAGGAAATCTGAAACTGTTTACCATTGCT
GAAAGCCTGGGGGCGGTTGAAAGCTTAATTTCTGTTCCTGCAAGAATGACACATGCCTCTATTCCGAGAGAACGCCGGCT
TGAGCTCGGCATTACGGACGGCTTGATCAGAATTTCTGTAGGAATTGAAGATGCGGAAGACTTGTTGGAAGATATCGGCC
AAGCGCTTGAAAATATATAA

Protein sequence :
MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEYSRTANPTRTALEALVTELESGEAGYAFSSGMAAITA
VMMLFNSGDHVVLTDDVYGGTYRVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA
KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEELHFVQNSTGGVLGPQDSWLLMR
GIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPGSSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIA
ESLGAVESLISVPARMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-109 59
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-107 58
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-77 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mccB YP_007534710.1 cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway MccB BAC0207 Protein 1e-68 44