Gene Information

Name : mccB (BAM5036_2375)
Accession : YP_007498065.1
Strain : Bacillus amyloliquefaciens UCMB5036
Genome accession: NC_020410
Putative virulence/resistance : Resistance
Product : cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway
Function : -
COG functional category : -
COG ID : -
EC number : 4.4.1.1
Position : 2559161 - 2560303 bp
Length : 1143 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10939241, 15760717, 17056751; Product type e : enzyme

DNA sequence :
ATGAAGAAAAAAACGCTGATGGTGCACGGAGGAATTACGGGAGATGAAAAAACAGGAGCGGTTTCCGTACCGATTTATCA
AGTAAGCACGTACCAACAGCCGAAAGCGGGCGAGCACACGGGTTATGAATATTCAAGAACGGCCAATCCGACGCGGACGG
CGCTTGAAAGCTTAATTGCGGAGCTTGAAGGCGGCGCGGCGGGATATGCGTTCGGCTCAGGCATGGCTGCGATTACTGCC
GTCATGATGCTGTTTGACAGCGGCGATCATGTTATTTTGACGGATGATGTATACGGCGGAACTTACCGGGTGATGACAGG
CGTGCTGAACCGCTTCGGCATTGAAGCGGACTTTGTCGATACGAGCAGTGAAGAAAAAGTCAAAAAGGCCATTCGCCCGA
ATACGAAAGCCATTTATATCGAAACACCGACAAACCCGCTATTAAAAGTGACTGACCTCAAACTGATGTCTGACATCGCA
AAAGAAGCGGGTGTATTGCTTATCGTCGATAATACGTTTTACACGCCGTATTTCCAGCAGCCGCTCAGCTTCGGCGCGGA
CATCGTGCTTCACAGCGCGACAAAATATCTCGGCGGCCACAGCGATGTCGTCGGCGGCTTAGTCGTCACGGCTGATAAAG
AACTGGGCGAAAAGCTTCATTATGTGCAAAACTCAACGGGCGGCGTTTTAGGACCGCAGGATTCATGGCTTTTGATGAGA
GGCATTAAAACGCTGGGACTCAGAATGGATGCCATCAATCACAGCGCCGGAAAAATCGCCGGGCTGCTTGAAGCGCATGA
TGCCGTTCAGACGCTCTACTATCCCGGATCAGCGAAACACCCGGGCCATGAGCTGACAAAAGCACAAAGCTCCGGTTTCG
GCGGAATGATTTCCTTTGATGTCGGCAGCAGCGAACGCGTCGACGCGTTTTTAGAAAAATTGAACCTGTTTACGATCGCG
GAAAGTTTAGGAGCGGTTGAAAGCTTAATCTCCGTGCCGTCCAGAATGACGCACGCATCGATCCCGCGCGACCGCCGGCT
TGCGCTTGGCATTACCGACGGGCTCGTGCGGATCTCGGTCGGTATTGAGGATACTGAGGATTTAACGGCGGATGTGAAAC
AGGCGCTTGATTCACTTTTATAA

Protein sequence :
MKKKTLMVHGGITGDEKTGAVSVPIYQVSTYQQPKAGEHTGYEYSRTANPTRTALESLIAELEGGAAGYAFGSGMAAITA
VMMLFDSGDHVILTDDVYGGTYRVMTGVLNRFGIEADFVDTSSEEKVKKAIRPNTKAIYIETPTNPLLKVTDLKLMSDIA
KEAGVLLIVDNTFYTPYFQQPLSFGADIVLHSATKYLGGHSDVVGGLVVTADKELGEKLHYVQNSTGGVLGPQDSWLLMR
GIKTLGLRMDAINHSAGKIAGLLEAHDAVQTLYYPGSAKHPGHELTKAQSSGFGGMISFDVGSSERVDAFLEKLNLFTIA
ESLGAVESLISVPSRMTHASIPRDRRLALGITDGLVRISVGIEDTEDLTADVKQALDSLL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-110 62
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 8e-112 62
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-74 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mccB YP_007498065.1 cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway BAC0207 Protein 4e-65 43