Gene Information

Name : sctN (LAW_00556)
Accession : YP_007365639.1
Strain : Lawsonia intracellularis N343
Genome accession: NC_020127
Putative virulence/resistance : Virulence
Product : type III secretion system ATPase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 660438 - 661754 bp
Length : 1317 bp
Strand : -
Note : -

DNA sequence :
ATGGCGCTTGAATATATTGCTTCACTCCTTGAAGAGGCTGTGCAGAATACAAGTCCTGTAGAAGTTAGAGGAAGGGTTGA
ACAAGTTATTGGTACAATAATTCGTGCAGTTGTCCCAGGCGTTAAGATTGGTGAATTATGTGAACTACGTAACCCATGGG
ATAATTGGACCTTACAGGCTGAAGTAGTTGGTTTTGTAAAACATGTAGCTTTACTTACACCCTTAGGAGATCTCCAAGGT
ATTTCTCCCTCAACAGAAGTAATTCCTACAGGAATGGTTCATGCTATTCCAGTGGGAAGAGAGTTACTTGGTCGTGTATT
AAATGGACTTGGAGAACCTATAGATGGGAAAGCTCCATTACGTTTACGGACATACTATCCTGTATATGCAGATCCTCCTA
ATCCAATGTTACGTCGAATTATTGAGAAGCCAATTTCATTAGGTCTTCGTGTATTAGATGGAATATTAACTTGTGGTGAG
GGCCAAAGGATGGGTATTTTTGCTGCAGCTGGTGGAGGTAAAAGTACACTTTTATCAAGTATTATTAAAGGCACAACTGC
TGATGTTTGTATTTTAGCATTGATTGGTGAACGTGGTCGAGAAGTACGCGAATTTATTGAACATGATCTTGGAGCAGAAG
GTTTAAAGCGTTCTGTACTTGTTGTATCTACGTCTGATCGTTCTTCTATGGAGCGACTTAAATCAGCTTATACAGCAACT
GCAATTGCTGAATATTTTAGAGATCAAGGAAAGAAAGTTTTATTACTTATGGATTCTGTCACACGTTTTGGTCGTGCATT
ACGTGAAATAGGCCTTGCATCTGGAGAACCTCCAACACGTCGTGGGTTTCCACCTTCTGTCTTTTCTTCATTACCAAAAC
TTATGGAGCGAGCAGGAAACTCAGATAAAGGTTCTATTACAGCATTATATACTGTCCTTGTCGAAGGTGATGATATGACA
GAGCCAATTGCTGACGAAACACGTTCTATTCTAGATGGTCATATTATTTTATCAAGGAAGTTAGCTGCAGCAAATCACTA
TCCTGCTGTTGATGTCTTAGCTAGTGTAAGTCGTGTTATGAATGCTATAGTTACAAAGGAACATAAAGAAAATGCAGGGA
AATTAAGGAAATATCTTGCTAAATATGCAGAAGTTGAGCTTTTAGTCCAGATAGGAGAATATAAAGCAGGTAATGATCCT
GCTGCGGATGATGCTATAAAACATAATAAAGGGATTAATGCTTTTTTACAGCAGGGCCTAGATGAAAAAAGTACTTTTGA
GCAAACACTTCAGGCTTTAAAAAAAGCGGTGGCTTAA

Protein sequence :
MALEYIASLLEEAVQNTSPVEVRGRVEQVIGTIIRAVVPGVKIGELCELRNPWDNWTLQAEVVGFVKHVALLTPLGDLQG
ISPSTEVIPTGMVHAIPVGRELLGRVLNGLGEPIDGKAPLRLRTYYPVYADPPNPMLRRIIEKPISLGLRVLDGILTCGE
GQRMGIFAAAGGGKSTLLSSIIKGTTADVCILALIGERGREVREFIEHDLGAEGLKRSVLVVSTSDRSSMERLKSAYTAT
AIAEYFRDQGKKVLLLMDSVTRFGRALREIGLASGEPPTRRGFPPSVFSSLPKLMERAGNSDKGSITALYTVLVEGDDMT
EPIADETRSILDGHIILSRKLAAANHYPAVDVLASVSRVMNAIVTKEHKENAGKLRKYLAKYAEVELLVQIGEYKAGNDP
AADDAIKHNKGINAFLQQGLDEKSTFEQTLQALKKAVA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lscN AAO18044.1 LscN Virulence TTSS locus Protein 2e-140 67
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 1e-115 60
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 7e-115 60
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 1e-115 59
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 1e-115 59
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-114 59
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-115 59
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 7e-115 59
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-112 58
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 1e-112 58
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 3e-101 54
escN AAC31513.1 L0034 Virulence LEE Protein 3e-99 52
escN YP_003223475.1 translocator EscN Virulence LEE Protein 7e-100 52
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 3e-99 52
escN AAC38383.1 EscN Virulence LEE Protein 3e-99 52
escN AAK26715.1 EscN Virulence LEE Protein 6e-100 52
escN AAL57542.1 EscN Virulence LEE Protein 6e-100 52
escN NP_290268.1 hypothetical protein Virulence LEE Protein 4e-99 52
escN CAC81862.1 EscN protein Virulence LEE II Protein 6e-100 52
ECs4568 NP_312595.1 EscN Virulence LEE Protein 4e-99 52
escN CAI43874.1 EscN protein Virulence LEE Protein 5e-100 52
escN YP_003236088.1 translocator EscN Virulence LEE Protein 1e-99 52
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-92 52
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 2e-92 52
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 7e-96 51
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 7e-96 51
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 9e-100 51
unnamed AAL06369.1 EscN Virulence LEE Protein 2e-98 51
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 6e-89 50
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 5e-93 50
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 6e-94 50
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 5e-93 50
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 3e-94 50
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 6e-94 50
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 1e-94 50
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-94 50
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 3e-99 50
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 2e-93 50
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 2e-84 50
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 4e-91 50
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 1e-93 50
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 6e-86 49
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 6e-86 49
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 2e-80 45
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-81 45
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 1e-81 45
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-81 45
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 1e-81 45
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 6e-82 44
invC AAS66861.1 InvC Not tested SSR-2 Protein 4e-81 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
sctN YP_007365639.1 type III secretion system ATPase VFG0390 Protein 4e-141 67
sctN YP_007365639.1 type III secretion system ATPase VFG0048 Protein 1e-144 67
sctN YP_007365639.1 type III secretion system ATPase VFG0192 Protein 1e-141 66
sctN YP_007365639.1 type III secretion system ATPase VFG2144 Protein 1e-115 58
sctN YP_007365639.1 type III secretion system ATPase VFG0730 Protein 2e-99 52
sctN YP_007365639.1 type III secretion system ATPase VFG0812 Protein 2e-99 52
sctN YP_007365639.1 type III secretion system ATPase VFG0515 Protein 7e-95 50
sctN YP_007365639.1 type III secretion system ATPase VFG1254 Protein 7e-87 47
sctN YP_007365639.1 type III secretion system ATPase VFG2331 Protein 2e-77 46
sctN YP_007365639.1 type III secretion system ATPase VFG2459 Protein 4e-88 46
sctN YP_007365639.1 type III secretion system ATPase VFG0555 Protein 6e-82 45
sctN YP_007365639.1 type III secretion system ATPase VFG1778 Protein 9e-84 45
sctN YP_007365639.1 type III secretion system ATPase VFG2499 Protein 3e-80 45
sctN YP_007365639.1 type III secretion system ATPase VFG1008 Protein 2e-80 44