Gene Information

Name : Metho_0614 (Metho_0614)
Accession : YP_007312403.1
Strain : Methanomethylovorans hollandica DSM 15978
Genome accession: NC_019977
Putative virulence/resistance : Resistance
Product : copper/silver-translocating P-type ATPase,heavy metal-translocating P-type ATPase, Cd/Co/Hg/Pb/Zn-transporting
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 624652 - 627003 bp
Length : 2352 bp
Strand : +
Note : TIGRFAM: copper-(or silver)-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase

DNA sequence :
ATGACACAATCAATTCTAAAGGTAATTAATAAACAAAAAGTTGTTTTTCAAGTAGATGGAATTACCTGTCTGGACTGTGC
CCAAAAGTTTGAAAAAGCAGTTAATGAATTACCTGGAGTTCTAAGCGCTTCTTTGAACACCATGACAGGCAAGCTTACGG
TTGAAGGGATGGCTGACTTAGCAGCTATCAGACGACTAGGGCAGGATGAAAATTATACGATTAACCCAATGGAGCAAGTC
AAAAACAAAGCGCCTACTGTTTTTCAAGTAGACGGAATTACCTGTCTGGATTGTGCCCAAAAGTTCGAAAAAGCAGTTAA
TGAATTACCTGGAGTTCTAAGCGCTTCTTTGAACACCATGACAGGCAAGCTTGCAGTTGAAGGAAGGGCTAGCTTGGAAG
ACATCAGGCAATTAGGACAGGATGAGAACTATAAGATTAATCCGGTAGTGCAGCAGCGGTCTATAGCTCAACCGGTGAAA
AAAATTAATTGGGAAATGCTTCGTGCTGTTTTATCTGGTGTTAGTTTGGTTATTGCTGTGGGAGTGGAGAAATTCGGCGG
CTCCGCCACGGCTTACCTGCCGATGTACATTCTAGCTATGGTATTAGGTGGATGGGGTAATTTTAAGAAGGCATCCCATG
CTTTGCCACGTCTTAATTTTAACATGAGTGTACTCATGAGTGTGGCGGTTATTGGTGCTTTTGCCATCGGCCAATATGAA
GAAGGTGCTACTGTTGCCTTCCTTTACGCAATATCTGAAATGCTACAGGCATGGACAGTGGAAAAGGCACGCCGTTCCAT
TCGACAATTGATGGATATTGCTCCAAAAACAGCATTGTTACGCCGCTCTGGTAGCGAAGTGGAAACATCTGTCGAACAAA
TTAATATTGATGATATTATGATTGTCTACCCTGGTGAAAAAATTGCCATGGATGGCGAAATTGTTAAAGGTGAAAGTGCT
ATTAACGAGGCAGCCATCACCGGAGAATCTATTCCAGCGGATAAAGGTCCAGGTGCTGAAGTATTTGCAGGTACGCTCAA
TACTCACGGTTCTATCGAAGTGAAGGTAACAAAGCTAGTACAAGATACCACCATTGCCAAGATCATTCATATGGTAGAAG
AAGCTCAAAGCAAAAGAGCTCCATCTCAGGTATTTGTTGAAAAATTTGCAACTGTATATACTCCCATCGTAATGGCATTA
GCTATGGGTTTTATGTTTCTTCCACCTTTGTTATTAGGTTATGAGTGGACACCCTGGATTTATCGTGGACTAACTCTTCT
TGTAGTTGCCTGTCCTTGTGCTTTGGTGGTATCTACGCCGGTTGCAATTGTCAGTGCAATCAGCAATGCCGCTAAAAACG
GCGTATTAATTAAAGGGGGTATACACCTGGAAGAAGCCGGTTCCTTAAATGCCATTGCCTTCGACAAGACGGGAACATTG
ACAAAAGGAGAGGCAGTAGTCACTGATATAATACCTGTTGGCTCTACTCCGGAAAATAAGCTTTTACAAATGGCAGCTAA
TTTGGAAGCTCGCTCCGAACACCCTCTAGCAGTAGCTATCATTAAGGCAGCTCAGCAACGAGGTCATCAAGTGGTTCCAG
TAGAAGATTTTACAGCCATCGCTGGCAGAGGTGCACACGGTACAATTAATGCACAGAGGATCTATATTGGTAATCCGCGG
ATGTTCATAGAGAAGGGCATATCTCTAGAGCCGGTGATAAAGGAGATAGAAAGGCTGCAAGGGCAAGGTAAGACGGTTAT
GATTGTTGGGACTCCAAATACCTTTTTAGGTATAATTGCTGTAGCAGATGAAGTGCGTGAAAACAGCACCGATGCGGTTA
CTGCTCTTAAAAGTGCAGGTATCCAGCACACTATTATGCTTACCGGTGATAATGACGTAACTGCCAAAGCCATGTCGGCA
AAGGTAGGTGTTGATGAATATCGGGCTGAACTATTACCTCAGGACAAAGTCACAGTAGTACAAGAACTCCTGGGTAAATA
CAACAAAGTGGGTATGATTGGTGATGGCATCAATGACGCTCCAGCGCTCGCTCTATCTACTGTTGGCATCGCCATGGGTG
GAGCAGGTACTGATACGGCCCTTGAAACGGCAGACATTGTCCTTATGGCAGATGATTTAAGCAAGCTTCCATTTACTATC
CGGTTAAGTCGTAAAGCACTTGCGATCATCCATCAGAATATTGGCTTCTCACTGATAATCAAGGCTATCGCCATCCTGGC
AATATTCCCCGGCTGGCTGACGTTGTGGATGGCTATCCTCGCTGATATGGGTGCTACAATTATTGTAACACTTAACAGCT
TAAGGCTCTTAAAGGTGAATGGAAAAAAGTAA

Protein sequence :
MTQSILKVINKQKVVFQVDGITCLDCAQKFEKAVNELPGVLSASLNTMTGKLTVEGMADLAAIRRLGQDENYTINPMEQV
KNKAPTVFQVDGITCLDCAQKFEKAVNELPGVLSASLNTMTGKLAVEGRASLEDIRQLGQDENYKINPVVQQRSIAQPVK
KINWEMLRAVLSGVSLVIAVGVEKFGGSATAYLPMYILAMVLGGWGNFKKASHALPRLNFNMSVLMSVAVIGAFAIGQYE
EGATVAFLYAISEMLQAWTVEKARRSIRQLMDIAPKTALLRRSGSEVETSVEQINIDDIMIVYPGEKIAMDGEIVKGESA
INEAAITGESIPADKGPGAEVFAGTLNTHGSIEVKVTKLVQDTTIAKIIHMVEEAQSKRAPSQVFVEKFATVYTPIVMAL
AMGFMFLPPLLLGYEWTPWIYRGLTLLVVACPCALVVSTPVAIVSAISNAAKNGVLIKGGIHLEEAGSLNAIAFDKTGTL
TKGEAVVTDIIPVGSTPENKLLQMAANLEARSEHPLAVAIIKAAQQRGHQVVPVEDFTAIAGRGAHGTINAQRIYIGNPR
MFIEKGISLEPVIKEIERLQGQGKTVMIVGTPNTFLGIIAVADEVRENSTDAVTALKSAGIQHTIMLTGDNDVTAKAMSA
KVGVDEYRAELLPQDKVTVVQELLGKYNKVGMIGDGINDAPALALSTVGIAMGGAGTDTALETADIVLMADDLSKLPFTI
RLSRKALAIIHQNIGFSLIIKAIAILAIFPGWLTLWMAILADMGATIIVTLNSLRLLKVNGKK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 9e-173 52
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 7e-173 52
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 5e-169 50
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 4e-113 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Metho_0614 YP_007312403.1 copper/silver-translocating P-type ATPase,heavy metal-translocating P-type ATPase, Cd/Co/Hg/Pb/Zn-transporting BAC0298 Protein 1e-101 47
Metho_0614 YP_007312403.1 copper/silver-translocating P-type ATPase,heavy metal-translocating P-type ATPase, Cd/Co/Hg/Pb/Zn-transporting BAC0092 Protein 1e-92 42
Metho_0614 YP_007312403.1 copper/silver-translocating P-type ATPase,heavy metal-translocating P-type ATPase, Cd/Co/Hg/Pb/Zn-transporting BAC0124 Protein 5e-82 41