Gene Information

Name : Thethe_00207 (Thethe_00207)
Accession : YP_007297637.1
Strain : Thermoanaerobacterium thermosaccharolyticum M0795
Genome accession: NC_019970
Putative virulence/resistance : Resistance
Product : D-alanine--D-alanine ligase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 199604 - 200689 bp
Length : 1086 bp
Strand : +
Note : PFAM: D-ala D-ala ligase N-terminus; D-ala D-ala ligase C-terminus; TIGRFAM: D-alanine--D-alanine ligase

DNA sequence :
ATGGAAAAGCTAAAAGTGGCTGTTTTGTTTGGGGGACAATCTGGAGAGCATGAAGTGTCAAGGGTTTCAGCGACTTCGAT
AATAAATAACATTGATAGAGATAAATACGATGTATATATGGTAGGCATAACTAAGAAGGGCGAATGGTATTTGTACAACG
GAGATATTGAGAAAATAGCTACAGGCGAGTGGGAGAAAGATGCTGTACCTGCTTTGATAGGGCCATCGACTAAATACAAA
GGAATTCTGGCTTTTAAAGACAGTAGGTACGAATTTTACCCAATTGATGTCGTTTTTCCTGTACTTCACGGTCCTAATGG
AGAAGATGGAACAGTTCAGGGTCTTTTAGAGCTTTTAGAGATGCCGTACGTGGGTCCAAATGTACTGTCATCATCCTTAT
GCATGGACAAAGTTTTTTCAAAGAGGATTTTTTTAGAGGCTGGAATACCTACGCCTAAATTTACAGTTGTGTATAGAAAA
GAGTTAAATAATGTAGATAATTACGAAGAAATACGAAGAAGAGTATCAGAGATTGGATATCCGTGCTTTGTAAAACCTGC
AAATATGGGCTCCAGCGTAGGTATAACGAAGGTTCACAATGAAAATGAACTGATGGATGGCTTGAAATTGGCGTCAAAGT
ATGATAGAAAAATTATTATAGAAGAAGGAATAGATGCAAGGGAGATTGAGTGCTCAGTTCTAGGCAATGATAATCCTGAG
GCATCTATTGCTGGTGAGATAGTCCCGGCACATGAATTTTACGATTACGATGCGAAATATTTCGATGAAGCATCGAAGCT
TTTTATACCAGCACCTATACCAGATGTTAAGATGGAAGAGATAAGAGAGTTAGCGATTAAAGCATACGTTGCATTGGACG
TAAGAGGAATGGCAAGGGTTGACTTTTTGATGGACAAAAATACTGGTAAAGTTTACCTAAATGAATTGAATACTATACCT
GGATTCACGAAAATTAGCATGTATCCGAAGCTTTGGGAAGCATCAGGGAAACCATATAGCAAATTAATCGATGAGCTGAT
ACAATTGGCTTTATCTGCCAATAAAGAAAAATGTACAAACTGGTAA

Protein sequence :
MEKLKVAVLFGGQSGEHEVSRVSATSIINNIDRDKYDVYMVGITKKGEWYLYNGDIEKIATGEWEKDAVPALIGPSTKYK
GILAFKDSRYEFYPIDVVFPVLHGPNGEDGTVQGLLELLEMPYVGPNVLSSSLCMDKVFSKRIFLEAGIPTPKFTVVYRK
ELNNVDNYEEIRRRVSEIGYPCFVKPANMGSSVGITKVHNENELMDGLKLASKYDRKIIIEEGIDAREIECSVLGNDNPE
ASIAGEIVPAHEFYDYDAKYFDEASKLFIPAPIPDVKMEEIRELAIKAYVALDVRGMARVDFLMDKNTGKVYLNELNTIP
GFTKISMYPKLWEASGKPYSKLIDELIQLALSANKEKCTNW

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 2e-56 42
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 8e-57 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase AF310956.2.orf5.gene Protein 4e-57 42
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase AY145441.gene.p01 Protein 2e-57 42
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase AF130997.1.orf4.gene Protein 5e-53 42
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase AF277571.gene.p01 Protein 1e-54 42
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase U00456.gene.p01 Protein 4e-57 41
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase U35369.1.gene6.p01 Protein 4e-57 41
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase AE016830.1.gene2250. Protein 4e-57 41
Thethe_00207 YP_007297637.1 D-alanine--D-alanine ligase AY489045.gene.p01 Protein 1e-53 41