Gene Information

Name : Natpe_4232 (Natpe_4232)
Accession : YP_007282574.1
Strain :
Genome accession: NC_019963
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 20569 - 22941 bp
Length : 2373 bp
Strand : -
Note : PFAM: E1-E2 ATPase; Heavy-metal-associated domain; haloacid dehalogenase-like hydrolase; TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC

DNA sequence :
ATGACAGAGAATCCGGACGCAGCAGGAGAAACGAGCGGCGGCGGACAGCGACGTGAGCTGACCGCCCGCCTCGCCGTTCC
CGAGATGGACTGTCCCTCTTGCGCCCAAAAGGTGGACAAGAGCCTCCAGCGTGTCGACGGCATTACTGACGCCACGCTCC
AGCCGACCACCGGCACGGCCAACGTCACGTACGACCCTGATCGGACTAGCGAAGCCGACGTAATCAAGGCGATTGAAGGC
GCCGGCTACGAGGTCGTCGGGGGCTCGGACGCTGAGGGCGATGATGAGGACAACCAGGCGACCGACGGCGTCGACATCGC
GCCACCATCGGAGGTCTGGACGAGTCCTCGCGCGAAGAAGACGTGGCTCGGCGCGGCGTTCGTCACGCTCGGCCTCCTCT
TCGAATTCCTCCTCACCGGACAGAACGTCACGGTGGCGAGCGTCCTCGAGTACCCGCTCCACATCGCAGATGTCCTGTTC
CTCGGCGCCGTCGCCGCCAGCGGCATCCCCGTCGTCCGTAGCGGGTACTACTCCGCGAAGAACCGAAGCCTCGACATCGA
CCTGCTGATGGGGACGGCGATCATCGCGGCGACCGGTATCGGCTACTTCGTCGAGGCCGCCACGCTGGCCGTCCTATTCA
GCATCGCCGAGCTGCTCGAGGACTACGCGATGGACAGGGCACGGGACTCCCTGCGCGAGCTGATGGAACTCTCGCCCGAC
GAGGCGACCGTCCTTCGCGATGGTGAGGAAGTGACCGTTCCCGCCGAGGAGGTCGACGTTGGCGAGACCGTCGTCGTCCG
CCCCGGCGACAAGATTCCGCTCGACGGAACGGTCATCGACGGCGAGAGTGCAGTCGACCAGTCGCCGATCACGGGCGAGA
GCGTCCCCGTCGACAAGACTGCCGGCGACGAGGTCTACGCCGGCGCGATCAACGAAGAGGGGTACCTCGAGGTAGAGGTC
ACCTCGACCGCTGGCGATTCGACGCTCTCGCGCATCATCGAGATGGTACAGGGCGCACAGGCGAAGAAGACCGAGTCTGA
GCAGTTCGTCGACCGCTTCTCCGGCTACTACACACCCCTCGTCGTCGTGCTGGCAATCCTGACCGCCGCTATCCCGCCGC
TGGTTATCGCCGACCCCATCTCGGTGGACGTGGCCGGGTACGGGTTCACTTTCGCCGGCGACTGGCAGACCTGGTTCATC
CGCGGGCTCACCCTGCTGGTAATCGCCTGCCCCTGTGCGTTCGTCATCTCCACACCCGTCTCGGTGGTGTCGGGCATCAC
CAGCGCCGCGAAGAACGGCGTCCTGATCAAGGGCGGCAACTACCTCGAAGCGATGGGCGAAGTCGATGCCGTCGCGCTCG
ACAAGACGGGGACGCTCACGAAGGGCGAACTCGCCGTCACCGATGTCGTCCCGGTCGGCGACACCACTGAGGATGATCTG
CTCCGTCGCGCCGCCGGGCTGGAGCGGCGCAGTGAGCACCCCATCGCTGCGGCGATTCTCGCCCGTGCTGAGGAGGCGGG
CGTGGGCGACCTGCCCGACCCGAGTGGCTTCGAGAGCCTCACGGGGAAGGGCATCCGGGGCGAGATCGACGGCGAGACGT
ACTATGCGGGCAAGCCCGCGCTCTTCGAGGAGCTGGGCTTCGACCTCGCTCGAGCACGCCGCGAGACAGACGGCGGCGTC
GTGGCGGAAGAGGCGACCGAGGCCGACGACGGGGCGTTCGCCGAGGACGCGCTCACCTCACTGGAGCGGGAGGGCAAGAC
GGTCGTTATCGTCGGGACGGAGTCGGAACTGCTGGGTGCAATCGCCATCGCCGACGAGGTGCGCCCGGCCTCGAAGCGGG
CTGTCGAACGCCTGCACGAGCTGGGCGTCGAGCGCGTGGTGATGCTGACCGGGGACAACGAGGGCACCGCCCGCGCCATC
GCCGAGCAGGTCGGTGTCGATGAATATCGCGCCGAACTCCTACCCGACGAGAAGGTCGACGCAGTCGAGGAGTTACAGGC
GGAGTACGGGGAGGTCGCGATGGTCGGCGACGGCATCAATGACGCCCCCGCGCTGGCCACTGCGGAGGTCGGCATCGCGA
TGGGCGCGGCGGGCACCGACACCGCCCTCGAAACGGCTGATATTGCGTTGATGGGCGACGACATCGGGAAACTCCCGTAC
CTGTACGACCTGTCGCATACGGCCAACGGCGTGATCCGGCAGAACATCTGGGCGAGCCTCGGCGTGAAGCTTCTGCTCGC
GTTAGGCGTGCCGCTGGGCCTGGTCAGCGTTGCGCTGGCAGTCGTTGTCGGAGATATGGGGATGAGCCTCGGCGTCACCG
GGAACGCGATGCGGTTGTCACGAATCGAGCCCGATCGAATCATCGACGCCTGA

Protein sequence :
MTENPDAAGETSGGGQRRELTARLAVPEMDCPSCAQKVDKSLQRVDGITDATLQPTTGTANVTYDPDRTSEADVIKAIEG
AGYEVVGGSDAEGDDEDNQATDGVDIAPPSEVWTSPRAKKTWLGAAFVTLGLLFEFLLTGQNVTVASVLEYPLHIADVLF
LGAVAASGIPVVRSGYYSAKNRSLDIDLLMGTAIIAATGIGYFVEAATLAVLFSIAELLEDYAMDRARDSLRELMELSPD
EATVLRDGEEVTVPAEEVDVGETVVVRPGDKIPLDGTVIDGESAVDQSPITGESVPVDKTAGDEVYAGAINEEGYLEVEV
TSTAGDSTLSRIIEMVQGAQAKKTESEQFVDRFSGYYTPLVVVLAILTAAIPPLVIADPISVDVAGYGFTFAGDWQTWFI
RGLTLLVIACPCAFVISTPVSVVSGITSAAKNGVLIKGGNYLEAMGEVDAVALDKTGTLTKGELAVTDVVPVGDTTEDDL
LRRAAGLERRSEHPIAAAILARAEEAGVGDLPDPSGFESLTGKGIRGEIDGETYYAGKPALFEELGFDLARARRETDGGV
VAEEATEADDGAFAEDALTSLEREGKTVVIVGTESELLGAIAIADEVRPASKRAVERLHELGVERVVMLTGDNEGTARAI
AEQVGVDEYRAELLPDEKVDAVEELQAEYGEVAMVGDGINDAPALATAEVGIAMGAAGTDTALETADIALMGDDIGKLPY
LYDLSHTANGVIRQNIWASLGVKLLLALGVPLGLVSVALAVVVGDMGMSLGVTGNAMRLSRIEPDRIIDA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 4e-128 42
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 4e-128 42
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 6e-127 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Natpe_4232 YP_007282574.1 heavy metal translocating P-type ATPase BAC0298 Protein 4e-101 45
Natpe_4232 YP_007282574.1 heavy metal translocating P-type ATPase BAC0092 Protein 7e-90 42
Natpe_4232 YP_007282574.1 heavy metal translocating P-type ATPase BAC0100 Protein 1e-67 41