Gene Information

Name : ureC (BN45_50114)
Accession : YP_007268524.1
Strain : Mycobacterium canettii CIPT 140070017
Genome accession: NC_019952
Putative virulence/resistance : Virulence
Product : Urease subunit alpha
Function : -
COG functional category : -
COG ID : -
EC number : 3.5.1.5
Position : 2175622 - 2177355 bp
Length : 1734 bp
Strand : +
Note : Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme

DNA sequence :
ATGGCGCGGCTGTCAAGGGAGCGCTACGCGCAGCTGTACGGACCTACCACCGGCGACCGGATCCGGCTGGCCGACACCAA
CCTGCTGGTTGAGGTCACCGAAGACCGGTGTGGGGGACCGGGACTGGCCGGTGACGAGGCGGTGTTCGGCGGCGGCAAGG
TGCTGCGCGAGTCCATGGGCCAGGGCCGTGCGAGCCGGGCCGACGGTGCCCCCGACACCGTGATCACCGGTGCGGTGATC
ATCGACTACTGGGGAATCATCAAGGCCGACATCGGGATTCGCGATGGCCGCATCGTCGGAATCGGAAAGGCCGGCAATCC
CGACATCATGACAGGTGTGCATCGGGATCTCGTCGTCGGGCCATCCACCGAAATCATCAGCGGCAACCGTCGAATCGTCA
CCGCGGGCACCGTCGACTGTCACGTGCACTTGATCTGTCCGCAGATCATCGTCGAAGCCTTGGCCGCGGGCACCACCACG
ATCATCGGCGGTGGCACCGGACCCGCCGAGGGCACCAAGGCCACCACAGTCACCCCCGGCGAGTGGCACCTGGCCCGGAT
GCTGGAGTCACTGGACGGTTGGCCGGTGAACTTCGCCCTGCTCGGCAAGGGAAACACCGTGAATCCCGACGCGCTGTGGG
AGCAATTGCGCGGCGGCGCATCGGGTTTCAAACTCCACGAAGACTGGGGATCGACACCTGCTGCCATCGATACCTGCTTG
GCGGTCGCCGACGTGGCCGGGGTGCAAGTTGCGCTGCACTCCGACACCCTCAACGAGACCGGATTCGTCGAAGACACCAT
CGGCGCGATCGCCGGACGGTCGATTCACGCCTACCACACCGAGGGCGCCGGCGGCGGGCACGCACCGGACATCATTACCG
TCGCGGCGCAACCGAATGTGCTGCCCAGCTCGACCAATCCGACCCGCCCGCATACGGTGAACACCCTTGACGAGCATCTC
GACATGCTGATGGTGTGCCACCACCTCAACCCCCGGATCCCGGAGGACCTCGCGTTTGCCGAAAGCCGGATCCGACCGTC
CACCATTGCGGCAGAAGATGTGTTGCACGATATGGGGGCAATCTCGATGATTGGCAGCGATTCCCAGGCGATGGGCCGTG
TCGGCGAGGTGGTGCTGCGCACCTGGCAGACCGCGCACGTGATGAAAGCCCGCCGCGGGGCACTGGAAGGTGACCCGTCC
GGTAGCCAAGCCGCCGACAACAACCGGGTCCGCCGCTACATCGCCAAATACACCATCTGCCCGGCCATCGCACACGGCAT
GGATCACCTGATCGGTTCGGTGGAGGTGGGAAAGTTGGCCGACCTGGTGTTGTGGGAGCCGGCGTTTTTCGGGGTTCGCC
CGCACGTCGTGCTCAAAGGCGGGGCGATCGCCTGGGCGGCGATGGGCGACGCGAACGCGTCGATCCCGACCCCGCAACCG
GTGCTCCCGCGACCGATGTTCGGCGCGGCCGCGGCAACCGCGGCGGCGACCTCGGTGCACTTCGTCGCGCCGCAATCCAT
CGACGCGCGCCTGGCGGACCGGCTCGCGGTCAATCGGCGACTAGCGCCGGTGGCCGACGTGCGCGCAGTGGGCAAGACCG
ACCTGCCGCTCAATGACGCCCTACCGAGCATCGAGGTCGATCCCGACACCTTCACCGTGCGCATCGACGGCCAGGTGTGG
CAACCGCAGCCGGCCGCCGAACTACCTATGACACAACGGTATTTCCTGTTCTAA

Protein sequence :
MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAGDEAVFGGGKVLRESMGQGRASRADGAPDTVITGAVI
IDYWGIIKADIGIRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTT
IIGGGTGPAEGTKATTVTPGEWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCL
AVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIHAYHTEGAGGGHAPDIITVAAQPNVLPSSTNPTRPHTVNTLDEHL
DMLMVCHHLNPRIPEDLAFAESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMKARRGALEGDPS
GSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKLADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTPQP
VLPRPMFGAAAATAAATSVHFVAPQSIDARLADRLAVNRRLAPVADVRAVGKTDLPLNDALPSIEVDPDTFTVRIDGQVW
QPQPAAELPMTQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 9e-147 62
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 9e-147 62
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-147 58
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-147 58
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-147 58
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-147 58

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_007268524.1 Urease subunit alpha VFG0270 Protein 4e-131 55