Gene Information

Name : metB (BN45_30121)
Accession : YP_007267763.1
Strain : Mycobacterium canettii CIPT 140070017
Genome accession: NC_019952
Putative virulence/resistance : Resistance
Product : Cystathionine gamma-synthase, PLP-dependent
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 1260465 - 1261631 bp
Length : 1167 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3307782, 6361020, 87326410, 90148970, 9843488; Product type e : enzyme

DNA sequence :
ATGAGCGAAGACCGCACGGGACACCAGGGAATCACTGGATTGGCCACCCGAGCCATCCACGCCGGCTACCGCCCTGACCC
GGCTACCGGGGCGGTCAACGCGCCGATCTATGCCAGCAGCACCTTCGCCCAAGACGGCGTCGGCGGTCTGCGCGGCGGAT
TCGAATACGCACGCACCGGCAACCCCACCCGGGCGGCGTTGGAAGCCTCGCTGGCGGCCGTCGAGGAGGGTGCTTTTGCG
CGGGCATTCAGTTCCGGGATGGCCGCGACCGACTGCGCCCTGCGGGCGATGTTGCGGCCCGGAGACCACGTCGTCATTCC
CGATGACGCCTACGGCGGCACATTCCGGTTGATAGACAAGGTGTTCACCCGGTGGGATGTCCAGTACACGCCGGTGCGGC
TTGCCGATCTGGATGCGGTGGGTGCCGCGATTACGCCGCGCACCCGGCTGATTTGGGTGGAGACGCCCACCAATCCGCTA
CTGTCGATCGCCGATATCACGGCCATTGCCGAGCTGGGCACAGAAAGATCGGCAAAAGTATTGGTGGACAATACCTTTGC
CTCACCCGCGTTGCAGCAGCCGTTGCGGCTGGGCGCCGATGTGGTGCTGCACTCGACTACCAAGTACATCGGCGGCCATT
CCGACGTGGTGGGAGGTGCGCTGGTCACCAACGACGAAGAGCTGGACGAGGAGTTCGCTTTCCTGCAGAACGGCGCCGGC
GCGGTGCCCGGACCATTCGACGCCTACCTGACCATGCGCGGCCTGAAGACCTTGGTGCTGCGGATGCAGCGGCACAGTGA
AAATGCCTGTGCGGTAGCGGAATTCCTCGCTGATCATCCGTCGGTGAGTTCTGTGTTGTATCCGGGTTTGCCCAGTCACC
CCGGGCATGAGATTGCCGCGCGACAGATGCGCGGCTTCGGCGGCATGGTTTCGGTGCGGATGCGGGCCGGTCGGCGTGCG
GCGCAGGACCTGTGTGCCAAGACCCGCGTCTTCATCCTGGCCGAGTCGTTGGGTGGGGTGGAGTCGCTGATTGAACATCC
CAGCGCCATGACCCATGCGTCGACGGCCGGTTCGCAATTGGAGGTGCCCGACGATCTGGTGCGGCTTTCGGTCGGTATCG
AAGACATTGCCGACCTGCTCGGCGATCTCGAACAGGCCCTGGGTTAA

Protein sequence :
MSEDRTGHQGITGLATRAIHAGYRPDPATGAVNAPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFA
RAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPL
LSIADITAIAELGTERSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG
AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRA
AQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-71 46
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-72 46
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-55 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_007267763.1 Cystathionine gamma-synthase, PLP-dependent BAC0207 Protein 2e-61 43