Gene Information

Name : hsdM (BN42_40735)
Accession : YP_007265483.1
Strain : Mycobacterium canettii CIPT 140070010
Genome accession: NC_019951
Putative virulence/resistance : Unknown
Product : Putative type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase)
Function : -
COG functional category : -
COG ID : -
EC number : 2.1.1.-
Position : 3190039 - 3191700 bp
Length : 1662 bp
Strand : -
Note : Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme

DNA sequence :
ATGCCGCCCAGGAAGAAGCAGGCGCCGCAGGCGCCGTCGACGATGAAGGAGCTCAAAGACACGCTCTGGAAGGCCGCCGA
CAAGCTGCGCGGGTCGGTGTCGGCCAGCCAATACAAGGACGTGATCCTGGGCCTGGTGTTCCTTAAGTACGTGTCCGACG
CCTACGACGAGCGGCGCGAGGCGATCCGTGCCGAGTTGGCGGCCGACGGGATGGAGGAGTCTCAGATAGAAGACTTGATC
GACGATCCCGAGGAGTACCAGGGTTACGGCGTGTTCGTGGTGCCGGTGAGTGCGCGCTGGAAGTTCTTGGCAGAGAACAC
AAAAGGCAAGCCGGCCGTTGGTGGTGAGCCGGCGAAGAACATCGGTCAGCTGATCGACGAGGCGATGGACGCGGTAATGA
AGGCCAATCCAACACTCGGTGGGACGCTGCCGCGGCTGTATAACAAGGACAACATCGACCAGCGCCGGCTCGGTGAGCTG
ATCGACCTATTTAACAGTGCGCGCTTCAGCCGGCAGGGCGAGCACCGCGCCCGGGATCTGATGGGGGAGGTCTACGAATA
CTTCCTCGGCAATTTCGCTCGCGCGGAAGGGAAGCGGGGTGGCGAGTTCTTTACCCCGCCCAGCGTGGTCAAGGTGATCG
TGGAGGTGCTGGAGCCGTCGAGTGGGCGGGTGTATGACCCGTGCTGCGGTTCCGGAGGCATGTTTGTGCAGACCGAAAAG
TTCATCTACGAACACGACGGCGATCCGAAGGATGTCTCGATCTATGGCCAGGAAAGCATTGAGGAGACCTGGCGGATGGC
GAAGATGAACCTCGCCATCCACGGCATCGACAATACGGGGCTCGGCGCCCGATGGGGTGATAGCTTCGCTCGCGACCAGC
ACCCGGACGTGCGGATGGACTACGTGATGGCCAATCCACCGTTCAACATCAAAGACTGGGCCCGCAACGAGGAAGACCCA
CGCTGGCGCTTCGGTGTTCCGCCCGCCAACAACGCCAACTACGCATGGATTCAGCACATCCTGTACAAGTTGGCGCCGGG
GGGTAGGGCGGGCGTGGTGATGGCCAACGGGTCGATGTCGTCGAACTCCAACGGCGAGGGGGATATTCGCGCGCAGATCG
TGGAGGCGGATTTGGTCTCTTGCATGGTCGCGTTACCCACCCAGCTGTTCCGCAGCACCGGAATCCCGGTGTGCCTGTGG
TTTTTCGCCAAGGACAAGGCGGCGGGTAAGCAGGGGTCTATCGACCGGTGCGGGCAGGTGCTGTTCATCGATGCGCGCGA
ACTGGGCTACATGGTGGACCGAGCCGAGCGGGCGCTGACCAACGAGGAGATCGTTCGCATCGGTGACACCTATCACGCAT
GGCGCGGGTCGAAGTCGGCTGCTGCCAAAGGGATTATGTACGAGGATGTTCCGGGTTTCTGTAAGTCGGCGACGTTGGCG
GAGATCAAGGCGACCGACTATGCGCTCACGCCGGGGCGGTATGTGGGTACGCCCGCGGTCGAGGACGACGGAGAGCCGAT
CGACGAGAAGATGGCCCGGTTGACGAAGGCGTTGCTGGAGGCGTTCGATGAGTCGGCGCGGCTGGAAAGGGTCGTGCGGG
AGCAACTGGGGCGGCTGAGACGAGCGATGGATGGAAAACCTTGCGGTTCGGGGAGTCCTTGA

Protein sequence :
MPPRKKQAPQAPSTMKELKDTLWKAADKLRGSVSASQYKDVILGLVFLKYVSDAYDERREAIRAELAADGMEESQIEDLI
DDPEEYQGYGVFVVPVSARWKFLAENTKGKPAVGGEPAKNIGQLIDEAMDAVMKANPTLGGTLPRLYNKDNIDQRRLGEL
IDLFNSARFSRQGEHRARDLMGEVYEYFLGNFARAEGKRGGEFFTPPSVVKVIVEVLEPSSGRVYDPCCGSGGMFVQTEK
FIYEHDGDPKDVSIYGQESIEETWRMAKMNLAIHGIDNTGLGARWGDSFARDQHPDVRMDYVMANPPFNIKDWARNEEDP
RWRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMSSNSNGEGDIRAQIVEADLVSCMVALPTQLFRSTGIPVCLW
FFAKDKAAGKQGSIDRCGQVLFIDARELGYMVDRAERALTNEEIVRIGDTYHAWRGSKSAAAKGIMYEDVPGFCKSATLA
EIKATDYALTPGRYVGTPAVEDDGEPIDEKMARLTKALLEAFDESARLERVVREQLGRLRRAMDGKPCGSGSP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 1e-123 50
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 3e-124 50
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 3e-123 49
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 1e-109 45