Gene Information

Name : mbtA (BN42_40317)
Accession : YP_007265127.1
Strain : Mycobacterium canettii CIPT 140070010
Genome accession: NC_019951
Putative virulence/resistance : Virulence
Product : Bifunctional enzyme MbtA: salicyl-AMP ligase (Sal-AMP ligase)-salicyl-S-ArCP synthetase
Function : -
COG functional category : -
COG ID : -
EC number : 6.-.-.-
Position : 2797179 - 2798861 bp
Length : 1683 bp
Strand : +
Note : Evidence 2b : Function of strongly homologous gene; PubMedId : 10419938, 11029592, 12775759, 9831524; Product type e : enzyme

DNA sequence :
ATGCCACCGAACGCGGCAGATGGCCGCCGACCTAGTCCCGACGGCGGCCTGGGCGGCTTTGTACCGTTCCCCGCGGATCG
GGCCGCGTCGTACCGGGCGGCCGGCTATTGGTCGGGGCGAACCCTGGACACCGTGCTCTCCGATGCCGCGCGGCGCTGGC
CTGACCGCCTCGCGGTGGCCGACGCCGGCGATAGTCCTGGCCACGGCGGCCTCAGTTACGCCGAACTCGACCAGCGGGCC
GACCGGGCCGCCGCGGCGCTGCATGGCCTGGGCATCACGCCAGGCGACCGGATACTGCTCCAGCTGCCCAACGGCTGCCA
GTTCGCGGTCGCCCTGTTCGCGCTATTGCGGGCGGGGGCGATCCCGGTAATGTGCCTGCCCGGTCACCGCGCCGCCGAAT
TGGGCCACTTCGCCGCCGTCAGCGCGGCCACTGGGCTGGTGGTCGCCGATGTGGCCAGCGGGTTCGACTATCGGCCGATG
GCGCGCGAACTTGTTGCCGATCACCCCACCCTGCGCCATGTCATCGTCGATGGCAATCCGGGACCGTTCGTGTCGTGGGC
GCAGCTGTGCGCCCAGGCCGGCACCGGTTCGCCGGCACCGCCGGCCGATCCCGGATCGCCGGCGCTGCTGCTGGTCTCCG
GCGGCACCACCGGCATGCCCAAACTCATTCCACGCACCCACGACGACTACGTGTTCAACGCGACGGCCAGCGCCGCACTC
TGTCGGCTTAGCGCCGACGACGTCTATCTGGTGGTGCTGGCCGCCGGCCACAATTTCCCGCTGGCCTGCCCGGGCCTGCT
CGGCGCGATGACGGTCGGGGCCACCACCGTCTTCGGCCCCGATCCCAGCCCGGAGGCCGCCTTCGCCACCATCGAGCGCC
ACGGCGTCACCGTCACCGCGTTGGTTCCGGCACTGGCCAAACTGTGGGCCCAATCCTGTGAGTGGGAGCCGGTGAGACCG
AAGTCACTACGGTTGTTGCAGGTTGGCGGGTCCAAGCTAGAACCCGAGGACGCTCGCCGGGTACGTACCGCGCTCACCCC
GGGCCTGCAGCAGGTGTTCGGCATGGCGGAGGGGCTGCTGAACTTCACCCGCATCGGCGACCCACCCGAAGTGGTGGAGC
ACACCCAGGGGCGGCCACTATGCCCGGCCGACGAACTGCGCATCGTCAACGCCGATGGCCAGCCGGCGGGATCCGGGGAG
GAAGGCGAACTCTTGGTGCGCGGGCCCTACACGCTGAACGGCTATTTTGCTGCCGAACGCGACAACGAGCGCTGCTTCGA
TCCGGACGGCTTCTACCGCAGCGGCGACCTGGTCCGCCGCCGCGACGACGGCAATCTGGTGGTCACCGGGCGCGTCAAGG
ATGTCATCTGCCGTGCGGGAGAAACCATCGCCGCCAGCGACCTCGAAGAACAGCTGCTGAGCCATCCGGCGATCTTCTCG
GCCGCGGCGGTGGGACTGCCTGACCAGTATCTGGGGGAAAAGATCTGCGCTGCAGTCGTTTTCGCGGGAGCTCCGATGAC
GCTTGCGGAGTTGAACGGCTACCTTGACCAGCGTGGTGTGGCCGCGCATACGCGACCCGACCAGCTGGTCGCGATGCCGG
CGCTGCCCACAACGCCGATCGGGAAGATCGACAAACGAGCGATCGTCCGCCAGATCGGCATCGCGACGGGCCCCATTGAC
TGA

Protein sequence :
MPPNAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAGDSPGHGGLSYAELDQRA
DRAAAALHGLGITPGDRILLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPM
ARELVADHPTLRHVIVDGNPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAAL
CRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATTVFGPDPSPEAAFATIERHGVTVTALVPALAKLWAQSCEWEPVRP
KSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGQPAGSGE
EGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFS
AAAVGLPDQYLGEKICAAVVFAGAPMTLAELNGYLDQRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQIGIATGPID

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-89 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-89 44
ybtE CAA21394.1 - Virulence HPI Protein 1e-88 43
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-88 43
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-88 43
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 43
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-88 43
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 43
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mbtA YP_007265127.1 Bifunctional enzyme MbtA: salicyl-AMP ligase (Sal-AMP ligase)-salicyl-S-ArCP synthetase VFG1817 Protein 0.0 98
mbtA YP_007265127.1 Bifunctional enzyme MbtA: salicyl-AMP ligase (Sal-AMP ligase)-salicyl-S-ArCP synthetase VFG0168 Protein 6e-90 45