Gene Information

Name : Echvi_4481 (Echvi_4481)
Accession : YP_007226669.1
Strain : Echinicola vietnamensis DSM 17526
Genome accession: NC_019904
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 5359779 - 5361722 bp
Length : 1944 bp
Strand : -
Note : PFAM: Pyridine nucleotide-disulphide oxidoreductase; Heavy-metal-associated domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: mercuric reductase; copper ion binding protein

DNA sequence :
ATGGTTAAAATAAGAAATATGTTTACTCCTAAGAGTAACAAGATCGGTGAAGGACAAAAAAGTTTATCGGAAGTTGTGCT
GGAAATAGAAGGCATGACCTGCGATCATTGCGCCACCGGTATTGAGAAAAAGGTTGGTCATCTTGTTGGAACAGCAAGTC
AGAAGGTAAACTATCCGGAGGGAAAGGGAATATTCTCCTACGATCCTGAAAAGGTTTCAAAGAAAGAGATCATAGATACC
ATTAACGGCATGGGCAATTACTCCGTTAAGAAGGAATTGCCTGCATCATCAAATGGTCAGGGAACTGAAGAAGAAGTAAC
GTTTAGCATTTCCGGGATGACCTGTGACCATTGCGCCACCTCCATTGAGAAGCGCTTTGAAGGCCATGAAGGTTTGATCT
CCAAATCGGTGAGTTATGCCGATGAAAAAGGCACATTTATCTTCAACCCCGATAAAATAAGCCGTCAGGAAATTATTGAA
ACGATCAACAAGGAGGGCAATTACAAAGTACAAAAGGAAATTGGAGGAAACGGCAACCTGGAACGCGCAGATCCCGGGCA
ACACGATCTGATCATCATAGGTGGAGGATCTGCGGCATTTTCAGCGGCCACTACGGCCAATGAACTTGGGTTGACCGTGT
TGATGGTGAATGCCGGACTGGACATTGGCGGCACCTGTGTGAATGTGGGTTGCGTACCCTCCAAACATTTGATCAGAGCT
GCAGAGCAGGTTCACCGGGCGCAGCATTCGCCTTTTAATGGCGTGTCAGGCGCAAATCCAACTTTTGATTTCAAGGCTAC
CATACAACAGAAAAAAGAATTGGTGGCAGCCCTGCAAAAGAAGAAATACCTGGGCGTGGTGGGTGACCTGGATAATATCA
CTATTCTGGAGGGTTGGGCCAGGTTCGTGGATGCGCACACCATTGAAGTGGATGGAAAGCCGTACAAAGGCATGAAGTAT
TTGCTGGCAACTGGCGCCACAACCAATGTGCCTGACCTGCCAGGCTTAGAGGATGTTGGGTACCTGACGAATGAAACACT
GTTTGACCTGGAGGAACAGCCCGAACACTTAATCGTGCTTGGAGCCGGATACATTGCGTTGGAGATTGCCCAGGCATATC
ATCGCTTTGGCACTAAGGTCACCATGTTGCATCGGTCAGAAAGAATTCTACGAACACAGGCTGCCGATATTACGGATGAC
CTGACATCCCATTTTACAGAGGAAGGCATTGAGGTCCATACCAATGTCAGTATTCAAAAATTCGAAAAGAACGGAGATGC
CATAGTGGCCCATACCAATGAGGGGACTTTTGAAGCTTCTCATGTGCTGGTAGCCACAGGAACCAGACCGAATACCAGCG
GTCTGGCGATTGAAAACGCTGGTGTCAATCTCAATAAAACAGGTCATATTTTAGTCAATACTAAACAGGAGACGAATGTA
GGCCACATTTATGCGGCAGGGGATTGTACCGATACACCTGCATTCGTATATACCGCTGCAAAAGAAGGAAAGGTCGCTGT
ATTAAACGCTTTCCAAAGCACCGGCGATATGGTCGATTATACAGGCCTTCCATGGGTCGTATTTACAGATCCGCAGATAG
CAGGGGCTGGCTTGGACGAAAAGGAGGCCGAAGAAGCAGGGATACCTTATGAAACCAGTGTGATGCCGTTAACCGAGGTG
CCACGTGCACAAGCAGCTTTGGACACGCGGGGGGTTATCAAACTGATCAGAAACAGTGAGACAGATAAACTTATTGGTGG
ACGAATCATCGCTCCTGAGGGAGGCGAATTGGCTATGCAAGTCAGTCTGGCAATTAAAGCCGGAATGACTATTCAGGAAC
TGGCCGATGCATTTCACCCTTACCTGACCTTATCAGAAGGAGTGAAACTGGCTGCCATCACCTTTAATAAAGATGTGTCA
GAATTGAGTTGTTGTGCCAGTTAA

Protein sequence :
MVKIRNMFTPKSNKIGEGQKSLSEVVLEIEGMTCDHCATGIEKKVGHLVGTASQKVNYPEGKGIFSYDPEKVSKKEIIDT
INGMGNYSVKKELPASSNGQGTEEEVTFSISGMTCDHCATSIEKRFEGHEGLISKSVSYADEKGTFIFNPDKISRQEIIE
TINKEGNYKVQKEIGGNGNLERADPGQHDLIIIGGGSAAFSAATTANELGLTVLMVNAGLDIGGTCVNVGCVPSKHLIRA
AEQVHRAQHSPFNGVSGANPTFDFKATIQQKKELVAALQKKKYLGVVGDLDNITILEGWARFVDAHTIEVDGKPYKGMKY
LLATGATTNVPDLPGLEDVGYLTNETLFDLEEQPEHLIVLGAGYIALEIAQAYHRFGTKVTMLHRSERILRTQAADITDD
LTSHFTEEGIEVHTNVSIQKFEKNGDAIVAHTNEGTFEASHVLVATGTRPNTSGLAIENAGVNLNKTGHILVNTKQETNV
GHIYAAGDCTDTPAFVYTAAKEGKVAVLNAFQSTGDMVDYTGLPWVVFTDPQIAGAGLDEKEAEEAGIPYETSVMPLTEV
PRAQAALDTRGVIKLIRNSETDKLIGGRIIAPEGGELAMQVSLAIKAGMTIQELADAFHPYLTLSEGVKLAAITFNKDVS
ELSCCAS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 6e-91 41
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 8e-91 41
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 2e-79 41
merA AFG30120.1 MerA Not tested PAGI-2 Protein 2e-79 41
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 3e-79 41
merA ABQ57371.1 MerA Not tested SGI1 Protein 4e-79 41
merA AGK07021.1 MerA Not tested SGI1 Protein 4e-79 41
merA AGK07079.1 MerA Not tested SGI1 Protein 4e-79 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Echvi_4481 YP_007226669.1 mercuric reductase BAC0649 Protein 4e-143 58
Echvi_4481 YP_007226669.1 mercuric reductase BAC0651 Protein 4e-91 41