Gene Information

Name : Theos_0971 (Theos_0971)
Accession : YP_006972121.1
Strain : Thermus oshimai JL-2
Genome accession: NC_019386
Putative virulence/resistance : Virulence
Product : 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 925362 - 926915 bp
Length : 1554 bp
Strand : +
Note : PFAM: Aldehyde dehydrogenase family; TIGRFAM: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase

DNA sequence :
ATGAGGTACGCAGACCAGGTGGCGGGCATCCCTTGGGAGACCATTGAGGCCATCCGGAAGGCCCTAAAGGAGAGGCCCGC
CCTGCACTTCATCGGCGGGGCCTTCGCCCCTTCGGAGGACGGGGCCACCTTCCCCTCCTTAGACCCCGCCACGGGGGAGG
TCCTGGGCCAGGCGGCCCGGGGCGGGGAAAAGGAGGTGGAGCGGGCGGCCCGGGCGGCCCACGAGGCCTTTCAGCGCTGG
AGCCGCACCCCGGCCCGGGAAAGGAAGCGCTACCTCCTGAAGATCGCCGAGCTCATAGAGAAGCGGGCGGACGAGCTTGC
GGTCACGGAGTGCCTGGACGCGGGGCAGGTCTTGAGGATCGTCCGGGCCCAGGTGGCCCGCGCGGCGGAGAACTTCGCCT
TCTACGCGGAGTACGCCGAGCACGCCATGGAGGACCGCACCTACCCCGTGGACCGGGACTGGCTCTACTACGCCCTTCGG
GTCCCCGCGGGGCCGGTGGGCATCATCACCCCCTGGAACGCCCCCCTGATGCTCTCCACCTGGCGCATCGCCCCCGCCCT
GGCCGCGGGGGACACCGTGGTCTTGAAGCCCGCGGAGTGGAGCCCCTTCACCGCCTCCAAGCTTGCGGAGATCGTCCAGG
AGGCCGACCTTCCCCCTGGGGTCTTCAACGTGGTCCAGGGCTTTGGGGAGGAGGCGGGGGCCGCGCTGGTGGCCCACCCC
CTCGTCCCCCTCATCACCCTCACGGGGGAGACGGAGACGGGGAAGATCGTCATGCGGGAGGCCGCCCGCCACCTCAAGCG
GCTTTCCCTGGAGCTTGGGGGGAAAAGCCCGGCCCTGGTCTTTGCCGACGCGGACCTGGAACGGGCCTTGGACGCGGTGG
TCTTCCAGATCTACTCCTTTAACGGCGAGCGGTGCACGGCAAGCTCCCGCCTCCTCGTGGAGGCCTCCATCTTTGAGGAC
TTCGTGGGGAAGGTGGCGGAGCGCGCCCGGGCCATCCGCGTGGGCCACCCCCTGGACCCGGAGACGGAGGTGGGCCCCCT
CATCCACCCCGAGCACCTGGAACGGGTCTTGGGCTACGTCCGGCTGGGCCTCGAGGAGGGGGCGAGGCTCCTCGTGGGCG
GGGAAAGGGCCCTCCGCTCCTTCCGGGGGGAGGACCTCTCCCGGGGCAACTACCTCCTCCCCACCCTCTTCGTGGGGGAG
AACCGCATGCGCATCGCCCAGGAGGAGATCTTCGGGCCCGTCCTCGTGGCCATCCCCTTCCGGGACGAGGAGGAGGCCTT
AAGGCTTGCCAACGACACCAGGTACGGCCTTGCGGCCTACGTCTTCACCCGGGACCTGGAGCGGGCCCACCGCCTGGCCC
TGGAGCTCCAGGCCGGGCTCATCTACCTCAACAGCCACAACGTCCGCCACCTCCCCACCCCCTTCGGCGGGGTGAAGGGG
AGCGGAGACCGCCGGGAAGGCGGCCACTACGCCTTTGAGTTCTACACCGACCTCAAGGCCGTGGGGCTTCCCCTAAGGCC
CCCCCACGTGCCCAAGTTCGGGAAAGGAGGCTAG

Protein sequence :
MRYADQVAGIPWETIEAIRKALKERPALHFIGGAFAPSEDGATFPSLDPATGEVLGQAARGGEKEVERAARAAHEAFQRW
SRTPARERKRYLLKIAELIEKRADELAVTECLDAGQVLRIVRAQVARAAENFAFYAEYAEHAMEDRTYPVDRDWLYYALR
VPAGPVGIITPWNAPLMLSTWRIAPALAAGDTVVLKPAEWSPFTASKLAEIVQEADLPPGVFNVVQGFGEEAGAALVAHP
LVPLITLTGETETGKIVMREAARHLKRLSLELGGKSPALVFADADLERALDAVVFQIYSFNGERCTASSRLLVEASIFED
FVGKVAERARAIRVGHPLDPETEVGPLIHPEHLERVLGYVRLGLEEGARLLVGGERALRSFRGEDLSRGNYLLPTLFVGE
NRMRIAQEEIFGPVLVAIPFRDEEEALRLANDTRYGLAAYVFTRDLERAHRLALELQAGLIYLNSHNVRHLPTPFGGVKG
SGDRREGGHYAFEFYTDLKAVGLPLRPPHVPKFGKGG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hpaE AAO17179.1 HpaE Not tested tcd island Protein 3e-99 48
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 9e-69 43
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-66 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 3e-68 41
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 3e-68 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 3e-68 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-67 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Theos_0971 YP_006972121.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase VFG0082 Protein 7e-67 41