Gene Information

Name : fliI (TPAMA_0402)
Accession : YP_006869723.1
Strain : Treponema pallidum Mexico A
Genome accession: NC_018722
Putative virulence/resistance : Virulence
Product : IIISP family Type III (virulence-related) secretory pathway protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 428218 - 429561 bp
Length : 1344 bp
Strand : +
Note : flagellum-specific ATP synthase FliI

DNA sequence :
ATGGAAGCAGACCTGTTGTGCAAGTATGAGGTGGCGCTCCGCGAGAGTGAGCCGGTAAAGTACGTTGGGCATGTGACAGC
AGTGAGGGGTTTATTGATTGAAAGTCGTGGCCCTCACGCGGTAGTTGGTGAATTGTGTCGGATTGTGTTGCGCCGCCAGG
GGCGACCGTTGATAGCAGAGGTAGTAGGACTTGCAGGATCGACGGTAAAACTGATGAGCTACACCGATACGCACGGGGTT
GAAGTTGGCTGTGCGGTGGTAGCAGAAGGGGCGGCACTTTCAGTCCCCGTAGGAGATGCTTTACTCGGACGCGTTTTGAA
CGCGTTTGGGAAGGCAATTGACGGGAAGGGGGAGATATATGCGCCGCTCCGCTCCGAGGTGTTGCGCGCGTCTTCTAATC
TTATGGAGCGTCTTCCGATTACGCGTCAAATGGTAACAGGAGTGCGGGTGCTTGATTCGTTGCTGGCAGTTGGTTGCGGA
CAACGTCTGGGTATTTTTTCCGGTTCGGGGGTTGGGAAGTCGACGCTGATGGGGATGATCGCGCGCAATACAGACGCAGA
TGTGTCGGTCATTGCCCTTATCGGGGAGCGTGGCCGTGAAGTGATGGATTTTGTTGCGCATGATTTGGGTCCTGAGGGTT
TGAAGCGCTCGGTAATAGTTAGTGCGACGTCTGATGAAAGTCCGCTTGCGCGGGTACGAGGTGCGTACACGGCGACAGCG
ATTGCAGAGTACTTTCGGGATCAAGGCAAACAGGTGCTGCTGCTGTTTGATTCTCTGACGCGCTTTGCAAAAGCTCAGCG
TGAGATTGGGTTAGCGTCGGGGGAGCTCCCTGCAACGCGTGGATATACCCCGGGGGTATTCGAAACGTTACCGAAACTGC
TTGAGCGTGCAGGTTCTTTTTCCATGGGGAGCGTCACCGCTTTTTATACTGTTTTGGTAGATGGGGACGATCTCGATGAG
CCGATATCAGACGCCGTGCGTGGAATTGTAGACGGGCACATTGTACTCAGTCGCGCGCTTGCGCAGCGCAATCACTATCC
TGCAATAGACGTGTTGCAAAGCGTTTCTCGCTTGGCGCACCGCGTGCTGGGTGCAGACATGAAAGAGGCAGTGCGCATAG
TGCGTCGTGCGCTTGCAGTGTACGCAGAAGTAGAGGATTTGGTACGAGTTGGTGCGTACCAGCAGGGGAGTGATGCAGAA
CTTGATCGAGCTATTGCGATGCGCGCAGAGCTTGAACGGTTCCTAACGCAAGGAGCCCAGGAGCGCGTGCGTTTTCAGGA
TACTGTAACGTCGCTGTCCATGCTGACAGGGCTCAGTATAGCACAGCCGCCTTCGGGTGTGTGA

Protein sequence :
MEADLLCKYEVALRESEPVKYVGHVTAVRGLLIESRGPHAVVGELCRIVLRRQGRPLIAEVVGLAGSTVKLMSYTDTHGV
EVGCAVVAEGAALSVPVGDALLGRVLNAFGKAIDGKGEIYAPLRSEVLRASSNLMERLPITRQMVTGVRVLDSLLAVGCG
QRLGIFSGSGVGKSTLMGMIARNTDADVSVIALIGERGREVMDFVAHDLGPEGLKRSVIVSATSDESPLARVRGAYTATA
IAEYFRDQGKQVLLLFDSLTRFAKAQREIGLASGELPATRGYTPGVFETLPKLLERAGSFSMGSVTAFYTVLVDGDDLDE
PISDAVRGIVDGHIVLSRALAQRNHYPAIDVLQSVSRLAHRVLGADMKEAVRIVRRALAVYAEVEDLVRVGAYQQGSDAE
LDRAIAMRAELERFLTQGAQERVRFQDTVTSLSMLTGLSIAQPPSGV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 2e-85 49
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 3e-85 49
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-85 49
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-87 49
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 4e-88 49
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 4e-87 49
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 1e-87 49
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 3e-88 49
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 3e-88 49
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 6e-87 49
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 1e-84 49
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-84 49
lscN AAO18044.1 LscN Virulence TTSS locus Protein 2e-85 48
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-86 48
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 2e-86 48
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 7e-70 47
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 3e-72 47
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 1e-72 46
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 1e-72 46
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 4e-69 46
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 4e-69 46
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 1e-73 46
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 2e-66 45
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 4e-78 45
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 4e-78 45
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 4e-79 44
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 8e-81 44
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 1e-72 44
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 7e-73 44
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 2e-73 44
escN YP_003236088.1 translocator EscN Virulence LEE Protein 1e-80 43
escN CAI43874.1 EscN protein Virulence LEE Protein 1e-79 43
escN AAC38383.1 EscN Virulence LEE Protein 6e-80 43
escN YP_003223475.1 translocator EscN Virulence LEE Protein 1e-79 43
escN AAC31513.1 L0034 Virulence LEE Protein 3e-80 43
escN NP_290268.1 hypothetical protein Virulence LEE Protein 4e-80 43
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 3e-80 43
ECs4568 NP_312595.1 EscN Virulence LEE Protein 4e-80 43
unnamed AAL06369.1 EscN Virulence LEE Protein 3e-80 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 2e-68 42
escN AAK26715.1 EscN Virulence LEE Protein 7e-79 42
escN AAL57542.1 EscN Virulence LEE Protein 7e-79 42
escN CAC81862.1 EscN protein Virulence LEE II Protein 2e-79 42
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 3e-79 42
invC AAS66861.1 InvC Not tested SSR-2 Protein 4e-66 42
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 3e-65 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2144 Protein 3e-92 51
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0048 Protein 6e-88 49
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0515 Protein 1e-85 49
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG1254 Protein 2e-80 49
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0192 Protein 5e-92 48
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0390 Protein 2e-87 48
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2499 Protein 1e-79 47
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2331 Protein 6e-77 46
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG2459 Protein 2e-68 43
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0730 Protein 3e-80 43
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG0812 Protein 2e-80 43
fliI YP_006869723.1 IIISP family Type III (virulence-related) secretory pathway protein VFG1778 Protein 1e-67 41