Gene Information

Name : HMPREF1038_01230 (HMPREF1038_01230)
Accession : YP_006743393.1
Strain : Streptococcus pneumoniae gamPNI0373
Genome accession: NC_018630
Putative virulence/resistance : Virulence
Product : DNA-binding response regulator VicR
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1139409 - 1140113 bp
Length : 705 bp
Strand : -
Note : KEGG: ava:Ava_1878 4.1e-48 two component transcriptional regulator, winged helix family K07659; Psort location: Cytoplasmic, score: 9.98

DNA sequence : 
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTACGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Protein sequence : 
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD42044.1 hypothetical protein Not tested PAI II 536 Protein 2e-33 42
c3565 NP_755440.1 response regulator Not tested PAI I CFT073 Protein 3e-33 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_012469.1.7685629. Protein 7e-101 100
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_002952.2859905.p0 Protein 8e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_009782.5559369.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_002951.3237708.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_002758.1121668.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_009641.5332272.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_013450.8614421.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_007622.3794472.p0 Protein 8e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_007793.3914279.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_003923.1003749.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_002745.1124361.p0 Protein 6e-52 56
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR HE999704.1.gene2815. Protein 8e-50 55
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_012469.1.7686381. Protein 2e-41 48
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR AE016830.1.gene1681. Protein 2e-44 47
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR FJ349556.1.orf0.gene Protein 4e-40 45
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR CP004022.1.gene3215. Protein 3e-33 44
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR CP001918.1.gene5135. Protein 1e-26 44
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR AM180355.1.gene1830. Protein 1e-36 43
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR NC_002695.1.915041.p Protein 6e-31 43
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR CP000034.1.gene3834. Protein 6e-31 43
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR CP001138.1.gene4273. Protein 6e-31 43
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR HE999704.1.gene1528. Protein 3e-32 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR AF162694.1.orf4.gene Protein 4e-33 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR AF155139.2.orf0.gene Protein 1e-37 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR DQ212986.1.gene4.p01 Protein 2e-35 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR AE000516.2.gene3505. Protein 5e-33 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR BAC0533 Protein 9e-31 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR CP000647.1.gene4257. Protein 9e-31 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR BAC0596 Protein 3e-27 41
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR CP001138.1.gene2239. Protein 3e-27 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR VFG1389 Protein 6e-31 45
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR VFG1563 Protein 9e-34 42
HMPREF1038_01230 YP_006743393.1 DNA-binding response regulator VicR VFG1702 Protein 1e-33 42