Gene Information

Name : R0052_00500 (R0052_00500)
Accession : YP_006654938.1
Strain : Lactobacillus helveticus R0052
Genome accession: NC_018528
Putative virulence/resistance : Virulence
Product : alkaline phosphatase synthesis transcriptional regulatory proteinphoP
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 87798 - 88514 bp
Length : 717 bp
Strand : +
Note : COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

DNA sequence :
ATGCCAAAAAAGATTCTCGTCGTCGACGATGAAAAGCCGATTTCTGATATCATTAAATTTAATTTAACTAAGGAAGGCTT
TGATGTCGACACCGCCTATGATGGTGAAGAAGCTGTTAAGAAAGTTGACGAATACGATCCAGACTTAATGATCCTGGATT
TGATGTTACCAAAGAAAGATGGACTCGAGGTTGCTCGTGAAGTTCGTCAAACGCACGATATGCCAATTATCATGGTAACA
GCTAAAGATACTGAAATTGATAAAGTACTTGGTCTAGAAATGGGTGCCGATGACTATGTCACTAAGCCTTTCTCTAATAG
AGAATTAGTTGCCCGCGTTAAGGCTAACTTGCGCCGTCGTGACATTGTTAAGAAGGCAGAAGCAGCTAACCAAGACGATA
CAGATAAGAATATTAAGATCGGTAACTTGGTTATCATGCCAGATGCCTATATCGTTGAAAAAGATGGTCGGAAGATTGAG
CTTACTCACCGTGAATTTGGGCTTCTTTACTACTTAGCTCAACATATGGGGCAAGTTATGACTCGTGAACACCTTTTACA
AACTGTTTGGGGCTATGACTACTTTGGCGATGTGCGTACAGTAGACGTAACTGTTCACCGTTTGAGAGAAAAGATTGAAG
ACAACCCAATCCAACCTCAAGTTTTGGTTACTCGTCGTGGTGTAGGATATTACGTAAAACAGCCAAGTGAAGGTTAA

Protein sequence :
MPKKILVVDDEKPISDIIKFNLTKEGFDVDTAYDGEEAVKKVDEYDPDLMILDLMLPKKDGLEVAREVRQTHDMPIIMVT
AKDTEIDKVLGLEMGADDYVTKPFSNRELVARVKANLRRRDIVKKAEAANQDDTDKNIKIGNLVIMPDAYIVEKDGRKIE
LTHREFGLLYYLAQHMGQVMTREHLLQTVWGYDYFGDVRTVDVTVHRLREKIEDNPIQPQVLVTRRGVGYYVKQPSEG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD42044.1 hypothetical protein Not tested PAI II 536 Protein 3e-31 41
c3565 NP_755440.1 response regulator Not tested PAI I CFT073 Protein 3e-31 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_012469.1.7685629. Protein 3e-65 65
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002952.2859905.p0 Protein 9e-50 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_009782.5559369.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002951.3237708.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_003923.1003749.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002758.1121668.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_007622.3794472.p0 Protein 8e-50 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_009641.5332272.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_013450.8614421.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_007793.3914279.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002745.1124361.p0 Protein 1e-49 53
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP HE999704.1.gene2815. Protein 2e-42 52
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_012469.1.7686381. Protein 4e-38 46
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP CP001918.1.gene5135. Protein 3e-28 45
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP AE000516.2.gene3505. Protein 2e-32 44
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002695.1.915041.p Protein 4e-33 44
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP CP000034.1.gene3834. Protein 4e-33 44
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP FJ349556.1.orf0.gene Protein 5e-34 44
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP BAC0533 Protein 2e-32 43
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP CP001138.1.gene4273. Protein 3e-32 43
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP CP000647.1.gene4257. Protein 2e-32 43
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP AF155139.2.orf0.gene Protein 8e-34 43
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_010079.5776364.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002952.2859858.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_007622.3794948.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_003923.1003417.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_013450.8614146.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002951.3238224.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_007793.3914065.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_002758.1121390.p0 Protein 3e-32 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP AE016830.1.gene1681. Protein 4e-37 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP AM180355.1.gene1830. Protein 1e-33 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP CP004022.1.gene3215. Protein 3e-31 42
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP AE015929.1.gene1106. Protein 5e-26 41
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_014475.1.orf0.gen Protein 6e-33 41
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_005054.2598277.p0 Protein 6e-33 41
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_010410.6002989.p0 Protein 2e-23 41
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_010400.5986590.p0 Protein 9e-23 41
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP NC_011595.7057856.p0 Protein 2e-23 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP VFG1563 Protein 1e-31 41
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP VFG1702 Protein 1e-31 41
R0052_00500 YP_006654938.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP VFG1389 Protein 2e-28 41