Gene Information

Name : mbtA (MSMEI_4404)
Accession : YP_006569153.1
Strain : Mycobacterium smegmatis MC2 155
Genome accession: NC_018289
Putative virulence/resistance : Virulence
Product : bifunctional enzyme mbtA: salicyl-AMP ligase + salicyl-S-ArCP synthetase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 4605449 - 4607125 bp
Length : 1677 bp
Strand : +
Note : -

DNA sequence : 
GTGACTCTGACCACGCCCCACCCCCGCCCCGAGCAATCCGAATCTGCAGCTCAGTCAAGCCTGCTGGCCGGATTCACGCC
GTTTCCGGCCGAGCGCGCACAGGCCTATCGGGCGGCCGGGTACTGGCGGGACCAGCTACTGGATTCGGTCCTGCGGACGG
CGGCCCGCACATGGCCGGACCACATCGCGGTGATCGATGCGGACCACCGGCACACCTACGCCGAACTCGACCGCCTCGCC
GACCGCGCCGCGGCAGGTATCGCGGGCCTGGGCATCCGCCCCGGCGACCGTGTGCTGGTCCAGCTGCCCAACACCGCGGA
GTTCGCCGTCGCACTGTTCGGCCTGCTGCGCGCGGGCGCGGTACCCGTGATGTGTCTGCCCGGGCACCGGCTGGCCGAGC
TCACGCATTTCGCCGAGGTCAGCTCGGCGGTGGCGCTCGTCGTGGCCGACACCGCAGGCGGTTTCGACCACCGCGACCTT
GCACGCGAACTCGTGAGGTCCCATCCGGACGTGCGTCACGTCCTCGTCGACGGCGACGCCGCGGAGTTCCTGTCCTGGGC
GGAGGTGACGCGTGCGGCGCCCGGGCCCGTCCCCGAGATCGCGCCCGATCCGGCCGCCCCGGCGCTGCTGCTCGTGTCGG
GCGGCACCACCGGTGCACCGAAACTCATCCCGCGCACACATCAGGACTACGTCTACAACGCCACGGCCAGTGCCGAGCTG
TGCCGGCTGACCGCCGACGACGTCTATCTCGTGGCGCTGCCTGCCGCCCACAACTTCCCACTGGCGTGCCCCGGCCTGCT
CGGTGCGATGACCGTCGGTGCCACCACGGTGTTCACCACCGACCCGAGCCCCGAGGCCGCGTTCGCCGCGATCGACGAGC
ACGGCGTCACGGCCACCGCACTGGTGCCTGCGCTGGCCAAGCTGTGGGCGCAGGCGTGTGCGTGGGAACCCTTGGCTCCC
AAGACGCTGCGCCTGCTCCAGGTGGGCGGGGCCAAGCTGGCTGCGCCGGACGCGGCGCTGGTGCGCGGGGCCCTCACCCC
GGGACTGCAGCAGGTGTTCGGCATGGCCGAGGGCCTGCTGAACTACACGCGCATAGGCGATCCCCCCGAGGTGCTGGAGA
ACACCCAGGGCCGCCCGTTGTCACCGGACGACGAGATCCGCATCGTCGACGAGGTCGGCAACGAGGTGCCGCCCGGCGCC
GAGGGGGAACTGCTGGTGCGCGGACCGTACACGCTCAACGGCTATTTCAACGCCGAGGCGGCCAACGAGCGCTCGTTCAG
CCCGGACGGCTTCTACCGCAGCGGCGACCGGGTACGCCGCTTCGCCGACGGCCCGCTCGCCGGGTATCTGGAGGTGACCG
GCCGGATCAAGGACGTCATCGTGCGCGGCGGCGAGAACGTCTCCGCACTCGATCTCGAAGAGCACCTGCTGACCCACCCG
AGCGTGTGGGCCGCCGCAGCGGTTGCGCTGCCCGACGAGTTCCTCGGCGAGAAGATCTGCGCCGTGGTCGTTTTCAACGG
ACCCCCGGTCAGCCTGGCCGAGTTGCACGCGCATCTGGAGCAGCGCGGCGTCGCTGCCCACAGCAGGCCCGACGCGCTGG
TCCCGATGCCGAGCCTGCCCACCACGGCCGTCGGCAAGATCGACAAGAAGGCGATCGTGCGTCAGCTCGGCGGGTAG

Protein sequence : 
MTLTTPHPRPEQSESAAQSSLLAGFTPFPAERAQAYRAAGYWRDQLLDSVLRTAARTWPDHIAVIDADHRHTYAELDRLA
DRAAAGIAGLGIRPGDRVLVQLPNTAEFAVALFGLLRAGAVPVMCLPGHRLAELTHFAEVSSAVALVVADTAGGFDHRDL
ARELVRSHPDVRHVLVDGDAAEFLSWAEVTRAAPGPVPEIAPDPAAPALLLVSGGTTGAPKLIPRTHQDYVYNATASAEL
CRLTADDVYLVALPAAHNFPLACPGLLGAMTVGATTVFTTDPSPEAAFAAIDEHGVTATALVPALAKLWAQACAWEPLAP
KTLRLLQVGGAKLAAPDAALVRGALTPGLQQVFGMAEGLLNYTRIGDPPEVLENTQGRPLSPDDEIRIVDEVGNEVPPGA
EGELLVRGPYTLNGYFNAEAANERSFSPDGFYRSGDRVRRFADGPLAGYLEVTGRIKDVIVRGGENVSALDLEEHLLTHP
SVWAAAAVALPDEFLGEKICAVVVFNGPPVSLAELHAHLEQRGVAAHSRPDALVPMPSLPTTAVGKIDKKAIVRQLGG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE CAA21394.1 - Virulence HPI Protein 6e-88 45
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-88 45
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 5e-88 45
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-88 45
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 7e-88 45
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-88 45
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 6e-88 45
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-88 45
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-88 45

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mbtA YP_006569153.1 bifunctional enzyme mbtA: salicyl-AMP ligase + salicyl-S-ArCP synthetase VFG1817 Protein 5e-173 71
mbtA YP_006569153.1 bifunctional enzyme mbtA: salicyl-AMP ligase + salicyl-S-ArCP synthetase VFG0168 Protein 3e-91 46
mbtA YP_006569153.1 bifunctional enzyme mbtA: salicyl-AMP ligase + salicyl-S-ArCP synthetase VFG0932 Protein 8e-81 42