Gene Information

Name : aphE (MYCMA_1289)
Accession : YP_006521038.1
Strain : Mycobacterium abscessus GO 06
Genome accession: NC_018150
Putative virulence/resistance : Resistance
Product : streptomycin 3''-kinase
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.1.87
Position : 2442906 - 2443619 bp
Length : 714 bp
Strand : +
Note : -

DNA sequence :
GTGTACCGCTCGCCCGACGGTTCTCGCTATGCGAAAGAAGGCGGTGCCGATCTTGCGGGTGAGCGGGACCGCATCGAATG
GCTTAGTGCTCAACGTATCCCGGGCCCGTCGGTGCTCGAGTGGGCGACCACGCCGGACGGCCCGCTGCTGATCACCTCGG
CGGTACCGGGCGTACCCGCCGACCAGCTCGACTCCGAGGGTTTGGGCAGGGCATGGTCTGCCATCGCCGCAGCGGTGCGG
GACCTGCACGCGCTGCCGACAGCGGGCTGTCCGTTTTCGCGGGAACTGGCCGCCATGGCAACGTTGGCCCGCGACGTCGT
GGCCCGCGACGCCGTGAACCCGGATTTTCTGACCGACGAAGACCGGGAGAGGCCGGCGACCGAGCTGCTATGCCGTGTTG
TGGCCGAACTGCCTCGGCGCCTGGCTCAGGAGCCCGACGACCTGGTGGTGTGCCATGGGGACTTGTGCCTGCCGAATATC
GTCATCGCGCCCGGAGACTTCTCGGTGGCAGGTTTCATCGATCTCGGCCGGCTCGGGTTGGCCGACCGGCACGCCGATCT
GGCCCTGCTCTTCGCCAATGCCCGGGAGACCTGGCCCGGGGACGGCTGGGTCGCGGCCGCCGCCCACGAGCGGTTCCTGA
ACCCGTACGGAGCGCCTGCCGACCCCGAACGGTTGGCGTTCTACCTGCGGTTGGATCCGCTGACCTGGGGATAG

Protein sequence :
MYRSPDGSRYAKEGGADLAGERDRIEWLSAQRIPGPSVLEWATTPDGPLLITSAVPGVPADQLDSEGLGRAWSAIAAAVR
DLHALPTAGCPFSRELAAMATLARDVVARDAVNPDFLTDEDRERPATELLCRVVAELPRRLAQEPDDLVVCHGDLCLPNI
VIAPGDFSVAGFIDLGRLGLADRHADLALLFANARETWPGDGWVAAAAHERFLNPYGAPADPERLAFYLRLDPLTWG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
strA YP_005176180.1 aminoglycoside 3''-phosphotransferase protein Not tested ICEPmu1 Protein 8e-50 49
strA AEA34675.1 aminoglycoside phosphotransferase Not tested Not named Protein 7e-50 49
strA YP_001800932.1 aminoglycoside-3''-phosphotransferase Not tested Not named Protein 1e-49 49
strA AFH57207.1 streptomycin resistance protein Not tested AbaR4a Protein 7e-50 49
strA AEQ20909.1 StrA, APH(3')-Ib streptomycin(3') phosphotransferase Not tested Tn6166 Protein 1e-49 49
strA AGK07031.1 StrA streptomycin phosphotransferase Not tested SGI1 Protein 7e-50 49
strA AEZ06049.1 StrA, APH(3')-Ib, streptomycin(3') phosphotransferase Not tested Tn6167 Protein 1e-49 49
strA AGK07089.1 StrA streptomycin phosphotransferase Not tested SGI1 Protein 7e-50 49
strA AFV47972.1 streptomycin (3') phosphotransferase StrA Not tested AbaR25 Protein 7e-50 49
strA AFV48000.1 streptomycin (3') phosphotransferase StrA Not tested delta-AbaR25 Protein 7e-50 49
strA ACK44539.1 StrA Not tested SGI1 Protein 7e-50 49
strA CAJ77025.1 Streptomycin phosphotransferase A Not tested AbaR1 Protein 4e-50 49
ABK1_0266 YP_005512838.1 StrA Not tested AbaR4d Protein 9e-50 49
BJAB07104_00282 YP_008207747.1 Aminoglycoside phosphotransferase Not tested AbaR25 Protein 9e-50 49
ABZJ_00266 YP_005524222.1 hypothetical protein Not tested AbaR22 Protein 9e-50 49
ABK1_0258 YP_005512830.1 StrA Not tested AbaR4d Protein 1e-49 49
BJAB0868_00286 YP_008211612.1 Aminoglycoside phosphotransferase Not tested AbaR26 Protein 4e-49 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
aphE YP_006521038.1 streptomycin 3''-kinase DQ336355.1.orf1.gene Protein 1e-51 55
aphE YP_006521038.1 streptomycin 3''-kinase AF024602.1.gene5.p01 Protein 5e-50 49
aphE YP_006521038.1 streptomycin 3''-kinase K00432.1.orf2.gene.p Protein 6e-29 44