Gene Information

Name : cadA (LPO_p0084)
Accession : YP_006510302.1
Strain :
Genome accession: NC_018141
Putative virulence/resistance : Resistance
Product : cadmium-transporting ATPase (Cadmium efflux ATPase)
Function : -
COG functional category : -
COG ID : -
EC number : 3.6.3.3
Position : 71557 - 73464 bp
Length : 1908 bp
Strand : +
Note : Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology

DNA sequence :
ATGGGCTGCTCCACTTGTCCTTCTCACAAAGAACCAATGCCCAAACTGTGGCATAATCCTAAAGTCATTACGGCAGCAAT
AGCCGGTATATTATTAACTATTGGTTTTGTAGGCTCATATTTGACACTACCAAGGATAATTGCTAACGGGTTTTACATAG
GCGCGGTGTTAATTGGTGGATATTATTTCGCACGGGAAGCTATAGAAGAATTTTTCAAAGAACATGAAATCGGTATTGAG
TTTTTGATGTCTACCGCTGCTATTGTTGCTGGTGTGATGGGACAATGGGCAGAATCGGCAACACTGGTTTTTTTATATTC
TATTTCTGAAGCAGCAGAGGGTTATGCTGGTGAAAGGGCGCGACATGCTATCAGAGTATTGATGGAACTTGCCCCAAAAT
CCGCATTAGTCCGACGTAATAATAGCGAGTTCCTAATACCTTTAGAAGACATTCAAATTGGAGATGAGTTTATTGTTCGT
CCTGGTGAAAGCATCGCTACAGATGGAGAGGTCATATCTGGACATTCTAGTGTAAACCAAGCGCCTATCACGGGTGAATC
AATTCCTGTTGAGAAATTTGTGGGAAATAAAGTATTTTCTGCAACTATTAACGGCGAGGGGACTCTTACTATTCGCGCTA
CCAAAAAATTTGCTGAGAACACGTTATCTCGTATTATTTTTCTTGTTGAAAAAGCACAGGATAAAAAAGGTCGCAGTCAA
CGATTTATAGAGCGTTTTGGCAATCTCTACAGTCCATTCGTTCTTTTAGCAGGGGTACTAATAGCTACCCTACCTCCTCT
ATTTGGGCTGCATTGGCAAGAATGGGTGCTACGTGCAACGGTGTTTATTGTTGCAGCTGCACCATGTGCTTTAGTAATTT
CTATCCCAATTACCCTTGTAGCTGCTCTTGGTACAGCCAGTCGAAACGGAATATTACTTAAGGGTGGGATATATTTAGAA
AAATTGGTTCAAATAAAGGTTATTGCGCTTGATAAAACAGGAACCTTAACACAAGGACAACCCAAGGTCACCGATATCAT
TTCGTTAAATAATTATACTCAGAACCAAATATTAAATGTAGCTGCCACCCTTGAATCGCGTTCCCAGCATCCACTGGCAC
ATGCCATTTTACAACAAGCAAAGGCAGAAAGTGTTGCATATAAACCTGTTGAACATTTTAAGTCATTGACTGGTTCAGGG
GTTCAGGGTTTTATAAATGGAGAACAATTTTATATTGGCAATCCAAAATTATTTATTGATATGGGTCTATTGGTAGAAAC
TGTAATTCAAGAAATAAATAAATTACAGACCGTTGGAAAGACTGTCGTATTAGTAGGAACAGATAAGGAAATTCTCGGTT
TAATTGCAATTACTGATCCTCTAAGATCTACAGCAAGGCAGATGGTATCGTCCCTAAAATTGATGGGTATTGAGCGTGTT
GTTATGCTCACTGGAGATAACTCGATAACTGCCGCGTCAATTGGAGTTCAAGCAGGTGTAGATGAAGTATTCTCTGATTT
ATCACCAGAAGATAAGACACGAAAAATTGAGGAACTGGAAAGACGTTACGGTAAGGTAATGATGGTTGGCGATGGAGTAA
ATGATGCTCCAGCACTTGCAGCAGCACATGTAGGAGTTGCAATGGGCGCCGCTGGAACCGATGTTGCATTAGAAACTGCG
GATGTAGCATTAATGGGTGATAATTTATTAAAATTACCTTATCTCATCGAGTTTAGTCATCGAACCTGGAATATAATTTT
ACAAAATTTAGGACTATCTATAATTGTTATTAGCTCTCTTATTGTCGGGGCGGTAACTGGCTATTTTACGTTGCCAATAG
CAGTTTTAGCCCATGAAATAAGTGAGCTTATTGTTATTGCAAGTGGTCTTCGCATGTTAAAATCTTAA

Protein sequence :
MGCSTCPSHKEPMPKLWHNPKVITAAIAGILLTIGFVGSYLTLPRIIANGFYIGAVLIGGYYFAREAIEEFFKEHEIGIE
FLMSTAAIVAGVMGQWAESATLVFLYSISEAAEGYAGERARHAIRVLMELAPKSALVRRNNSEFLIPLEDIQIGDEFIVR
PGESIATDGEVISGHSSVNQAPITGESIPVEKFVGNKVFSATINGEGTLTIRATKKFAENTLSRIIFLVEKAQDKKGRSQ
RFIERFGNLYSPFVLLAGVLIATLPPLFGLHWQEWVLRATVFIVAAAPCALVISIPITLVAALGTASRNGILLKGGIYLE
KLVQIKVIALDKTGTLTQGQPKVTDIISLNNYTQNQILNVAATLESRSQHPLAHAILQQAKAESVAYKPVEHFKSLTGSG
VQGFINGEQFYIGNPKLFIDMGLLVETVIQEINKLQTVGKTVVLVGTDKEILGLIAITDPLRSTARQMVSSLKLMGIERV
VMLTGDNSITAASIGVQAGVDEVFSDLSPEDKTRKIEELERRYGKVMMVGDGVNDAPALAAAHVGVAMGAAGTDVALETA
DVALMGDNLLKLPYLIEFSHRTWNIILQNLGLSIIVISSLIVGAVTGYFTLPIAVLAHEISELIVIASGLRMLKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 3e-112 45
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 2e-109 44
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 2e-109 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_006510302.1 cadmium-transporting ATPase (Cadmium efflux ATPase) BAC0100 Protein 6e-70 44
cadA YP_006510302.1 cadmium-transporting ATPase (Cadmium efflux ATPase) BAC0092 Protein 9e-93 43
cadA YP_006510302.1 cadmium-transporting ATPase (Cadmium efflux ATPase) BAC0298 Protein 3e-85 42
cadA YP_006510302.1 cadmium-transporting ATPase (Cadmium efflux ATPase) BAC0124 Protein 2e-76 41