Gene Information

Name : metB (LPV_1023)
Accession : YP_006508105.1
Strain : Legionella pneumophila HL06041035
Genome accession: NC_018140
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase, PLP-dependent
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 1021141 - 1022292 bp
Length : 1152 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3307782, 6361020, 87326410, 90148970, 9843488; Product type e : enzyme

DNA sequence :
ATGAATAAGACTCATTTCGATACACGTGCAATTCATGCTGGGCAAGAACCATGTAAAAGTACAGGGGCCGTGATGACCCC
TATTTATGCTACCTCCACCTATAAACAAATTGCTCCTGGCGAACATCTTGGCTATGAATACTCACGCACCCAGAACCCCA
CCAGAAAGGCCTATGAGGATTGCATAGCAAGTCTTGAATCAGGCCAAAAAGGATTTGCGTTTGCTTCAGGTATGGCTGCC
ATCAATACAGTTATTGATTTATTAGGTTCCGGAGATCACGTCGTTGCCATGGATGATCTTTATGGAGGGACTTTCCGGCT
TTTTGATAAAGTAAAAACCCGAACTTCTAATTTATCCTTTTCTTTTATTGATATGTCAGTACCCGAGAATATTGAAGCTG
CAATAACTCCGAAGACAAAATTACTATGGTTGGAAACCCCTTCCAATCCCATGCTAAAGCTAGCTAATTTACGAAAAATC
GCTGCTATTGCAAAAAAATATAATTTGATTACAGTTGCCGATAACACCTTTGCAACTCCCTGGATTCAACGCCCTCTTGA
ACTCGGATTTGACATTGTACTTCATTCAGCAACCAAATATCTGAACGGACATTCTGATGTAGTCAGTGGTGTCGTTGTGG
TCGGTGACAATTCAGTGTTGTCTGATAAAATTGCTTTTTTGCAAAATTCATGCGGCGCTGTAGCTGGCCCTTTCGACAGT
TTCCTGGTTCTGAGAAGCTTAAAAACATTATCCGTTCGTATGCAAAGGCACTGTGAAAACGCTAACCATCTGGCTAACTG
GCTTAGCAGCCACCCCAAGATTGAAAAAGTCATTTATCCCGGATTAAAAAGTCATCCGCAATATTCTCTTGCCAAGGAAC
AAATGAACAATTTCGGTGGTATGATATCTTTGGTACTTAAAGGTAGTCTTGAAGATGCCAAACGATTTTTAGCTCGCTGC
GAATTATTTACTTTGGCTGAAAGCCTGGGGGGTGTAGAAAGTTTAATTGAGCATCCTGCAATTATGACCCATGCCTCTAT
TCCAGTCGAACAACGCAAAGCCCTGGGCATAGAAGATGGTTTCATAAGATTATCAGTTGGTATTGAACACATTGATGATC
TGCGTGCCGATCTGGAGCATGCTTTAGGTTAA

Protein sequence :
MNKTHFDTRAIHAGQEPCKSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLGSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKYNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSVRMQRHCENANHLANWLSSHPKIEKVIYPGLKSHPQYSLAKEQMNNFGGMISLVLKGSLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-74 47
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-75 47
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-55 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_006508105.1 cystathionine gamma-synthase, PLP-dependent BAC0207 Protein 5e-67 45