Gene Information

Name : betB (LPV_0320)
Accession : YP_006507456.1
Strain : Legionella pneumophila HL06041035
Genome accession: NC_018140
Putative virulence/resistance : Virulence
Product : betaine aldehyde dehydrogenase, NAD-dependent
Function : -
COG functional category : -
COG ID : -
EC number : 1.2.1.8
Position : 330365 - 331831 bp
Length : 1467 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1879697, 89124888, 90304165, 92065800; Product type e : enzyme

DNA sequence : 
ATGGAAATTTACGAAATGTACATTGATGGAAAATTTACTTTAGCCAAAAGCGGAACTACTCGCGACATTTTTGATCCGGC
TAACGGGGAATTGATTGCAAGAGTGCCAGAAAGTGCCAAAGAAGATGCCATACTTGCTATCAAAGCAGCGAGAAAAGCCT
TCGATGAAGGAGAGTGGAGAAGATCACTGGCGCTTGATCGAGGCAAATTGTTATTCAAGCTTGCTGATTTGATTCGAGCC
AATGCTAAAATGTTGGCAGAGCTGGAAACTCGAAATTGCGGAAAGCCGTTACCCGAAGCGGAGTTTGATGTCACTGATGC
TGCCAATTGCTTTGAGTTTTACGGTGGGCTTGCGACTAAAATTCATGGTGAAACGATGTCGGTTCCAGCGAATTCATTTA
GTTACGTAGTACGTGAACCCATAGGCGTGTGTGGGCAAATCATTCCATGGAATTTTCCACTGCTTATGGCGGCCTGGAAA
CTTGCTCCCGCGCTTGCCGCAGGCAATACCGTGGTATTAAAACCATCAGAATTGACCCCGATAACAGCACTTGAGTTATT
CAAGTTGATTGATCAATGCGGATTTCCAGCGGGCGTGGTTAACCTCATTACTGGGCCGGGTATAGGAGTTGGAGAGGAGT
TGGCAAGTAATGCTATGGTGGATAAGGTTGCTTTCACCGGAGGATCGGTAACAGGCAGAAAAATCATGCAGGCGGCTACT
GGCAATTTGAAAAAAATCTCGTTAGAGCTTGGCGGAAAAAATCCAAATATTGTCTTTGCAGACTGTGACCTTGAAATGGC
AATCGACGGCGCCCTTTTTGGTGCTTTTGCAAATCAAGGGGAAGTCTGTTCTGCGGGTTCCCGCTTGCTAGTGGAGCGCT
CTATTCACAAAAAAATAGTAGAGGGAATGTTGAAAAAAATTCCAAATATCAAGCTTGGCCATGGTTTGGACGCCGGGGTA
AAAATGGGGCCTTTGGTTTCAAGTGCACATCGTGAAAAAGTGGAAAGTTATGTCAAGCTTGGAATGGAAGAAGGAGCCAA
ATTACTTTGCGGCGGTAAACGCCCGACAGGGAGTGAATTTGCAAAGGGAAATTTTTTCGAGCCAACCATTTTCGATGAAG
TGAAATCCACGATGCGCATTGCTCGTGAAGAAATTTTTGGTCCAGTACTTGTGGTCATCCCCTTTGACAACGAAGAAGAA
GCCATTCGCATTGCAAACGATACTGATTATGGCTTATCCGGGGCTGTATGGACGAAGAGCGTTACTCGGGCCCATCGAGT
CACATCTCAAATCCGTGCCGGGATTCTTTGGGTGAATCATTACCATCCAACCTATAATGAAATGCCTTGGGGCGGATACA
AACAAAGCGGAGCAGGTCGTGAGTTAGGTTTGTATGGCATTGAGAGTTACCTTGAGGTCAAGCAAGTGAATATTAACCTG
GATGAAACACCAATTGGTTGGTACTAA

Protein sequence : 
MEIYEMYIDGKFTLAKSGTTRDIFDPANGELIARVPESAKEDAILAIKAARKAFDEGEWRRSLALDRGKLLFKLADLIRA
NAKMLAELETRNCGKPLPEAEFDVTDAANCFEFYGGLATKIHGETMSVPANSFSYVVREPIGVCGQIIPWNFPLLMAAWK
LAPALAAGNTVVLKPSELTPITALELFKLIDQCGFPAGVVNLITGPGIGVGEELASNAMVDKVAFTGGSVTGRKIMQAAT
GNLKKISLELGGKNPNIVFADCDLEMAIDGALFGAFANQGEVCSAGSRLLVERSIHKKIVEGMLKKIPNIKLGHGLDAGV
KMGPLVSSAHREKVESYVKLGMEEGAKLLCGGKRPTGSEFAKGNFFEPTIFDEVKSTMRIAREEIFGPVLVVIPFDNEEE
AIRIANDTDYGLSGAVWTKSVTRAHRVTSQIRAGILWVNHYHPTYNEMPWGGYKQSGAGRELGLYGIESYLEVKQVNINL
DETPIGWY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 2e-76 44
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-71 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 7e-74 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 7e-74 41
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 7e-74 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-73 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
betB YP_006507456.1 betaine aldehyde dehydrogenase, NAD-dependent VFG0082 Protein 7e-72 41