Gene Information

Name : metB (LPO_0971)
Accession : YP_006504986.1
Strain : Legionella pneumophila Lorraine
Genome accession: NC_018139
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase, PLP-dependent
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 992062 - 993213 bp
Length : 1152 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3307782, 6361020, 87326410, 90148970, 9843488; Product type e : enzyme

DNA sequence :
ATGAATAAGACTCATTTCGATACACGTGCAATTCATGCAGGACAAGAACCATGTCAAAGTACAGGGGCCGTGATGACCCC
TATTTATGCTACCTCCACCTATAAGCAAATTGCCCCTGGCGAACATCTTGGCTATGAATACTCACGTACCCAGAACCCCA
CCAGAAAAGCCTATGAGGATTGCATAGCAAGCCTTGAATCAGGCCAAAAAGGATTTGCGTTTGCTTCGGGCATGGCTGCA
ATCAATACAGTTATTGATTTATTAGATTCCGGAGATCACGTCGTTGCCATGGATGATCTTTATGGAGGAACTTTCCGGCT
TTTTGATAAAGTAAAAACCCGAACTTCTAATTTATCCTTTTCTTTTATTGATATGTCAGTACCCGAGAATATTGAAGCTG
CAATAACTCCGAAGACAAAATTACTATGGTTGGAAACCCCTTCCAATCCCATGCTAAAGCTAGCTAATTTACGAAAAATC
GCTGCTATTGCAAAAAAACATAATTTGATTACAGTTGCCGATAACACCTTTGCAACTCCCTGGATTCAACGCCCTCTTGA
GCTCGGATTTGACATTGTACTTCATTCAGCAACCAAATATCTGAACGGACATTCTGATGTAATCAGTGGTGTCGTTGTGG
TCGGTGACAATCCCATGTTGTCTGATAAAATTGCTTTTTTGCAAAATTCATGCGGCGCTGTAGCTGGCCCTTTCGACAGT
TTCCTGGTTCTGAGAAGCTTAAAAACATTATCTCTTCGTATGCAAAGGCACTGTGAAAATGCCAACCATCTGGCTAACTG
GCTTAACGGCCACCCCAAGATTGAAAAAGTCATTTATCCCGGATTAAAAAGTCATCCGCAATATTCTCTTGCCAAGGAAC
AAATGAACGATTTCGGTGGTATGATCTCTTTGGTACTTAAAGGTGGTCTTGAAGATGCCAAACGATTTTTAGCTCGCTGC
GAATTATTTACTTTGGCTGAAAGCCTTGGGGGTGTAGAAAGTTTAATTGAACACCCTGCAATTATGACCCATGCCTCTAT
TCCAGTCGAACAACGCAAAGCCCTGGGCATAGAAGATGGTTTCATAAGATTATCAGTTGGTATTGAACACATTGATGATC
TGCGTGCCGATCTGGAGCATGCTTTAGGTTAA

Protein sequence :
MNKTHFDTRAIHAGQEPCQSTGAVMTPIYATSTYKQIAPGEHLGYEYSRTQNPTRKAYEDCIASLESGQKGFAFASGMAA
INTVIDLLDSGDHVVAMDDLYGGTFRLFDKVKTRTSNLSFSFIDMSVPENIEAAITPKTKLLWLETPSNPMLKLANLRKI
AAIAKKHNLITVADNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVISGVVVVGDNPMLSDKIAFLQNSCGAVAGPFDS
FLVLRSLKTLSLRMQRHCENANHLANWLNGHPKIEKVIYPGLKSHPQYSLAKEQMNDFGGMISLVLKGGLEDAKRFLARC
ELFTLAESLGGVESLIEHPAIMTHASIPVEQRKALGIEDGFIRLSVGIEHIDDLRADLEHALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-80 50
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-79 49
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-56 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_006504986.1 cystathionine gamma-synthase, PLP-dependent BAC0207 Protein 1e-69 46