Gene Information

Name : cadA (LPO_2817)
Accession : YP_006506679.1
Strain : Legionella pneumophila Lorraine
Genome accession: NC_018139
Putative virulence/resistance : Resistance
Product : zinc, cobalt and lead efflux system
Function : -
COG functional category : -
COG ID : -
EC number : 3.6.3.3
Position : 2940649 - 2942784 bp
Length : 2136 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10660539, 12746428, 21305696, 9364914, 9405611, 98070750, 99428388; Product type t : transporter

DNA sequence :
ATGACAACACCTTTAACCTTAACGACCTTTTTTGTTGCAGGGCTTGATTGTCCTGCTGAAGAGCAATTAATTAGGCGACA
ATTACAAACAATTCCGGAAATCGAAAAGATGGATTTTAACTTCATTGCCGAAGAAGTGACGATTCATCATCGTTTAAATA
CGATTGAGCCACTCCAGAGACAAATTGAAGCATTGGGCATGAGTGTTCGCACCAAAAGCAGCACTAAAAGTGATAGCCCA
AAAGAGGCCAATGATTTTTCTTGGTGGTGGCTTGCTGTAGCTGGATTGTTGGCTCTTTTCTCGGAAGTGCTCTCCTATTT
ATTTGGGACCGAGAAGTCAGTTTGGGTAGCGGCATTGGCATTAGTGGCTATGGCCATAAGTGGACCGCCTACCTTCAAAA
AGGGTTGGCTTGCTCTGCGCACGAAAGCCTTGAATATCAACAGCTTGATGATGATTGCAATAACAGGTGCCATACTCATC
GGCGAATGGCCGGAAGCGGCGATGGTCACCGTGTTATTTGCATTGGCTGAGCGTATTGAACGCTACTCATTGGATAAAGC
ACGATTAGCCATTCGAAGCCTGATGCAGATTGCACCGGATGAAGCAACCGTCAAAACGACGGAAGGAAAATGGCAAAAAT
TAGCGGTCGAGAACATCAAGTCAGGTGCAATTATCCTGGTTAAGCCAGGTGAGCGGATTGCCTTGGACGGCGTTATTGTG
AGTGGCCAAAGTAGCGTTAATCAAGCGCCCATTACTGGTGAGTCGATGCCTGTGAGCAAACAAACAGGAGACAGTGTGTT
TGCCGGTACGCTCAATGAGCGAGGCTCCTTTGAAGTGAAGGTGACCAAAGAATCAGGCGATACCCTGTTGGCTAAAATTG
GCAAAGCAATAGAACAAGCACAAGCAGAGCGGGCACCAACCCAGCGATTTGTTGATGAGTTCGCCAAATATTACACGCCA
ATCATGGTGCTCATTGCAGTAGCCGTTGCTCTGATTCCACCAATTGCATTGGGGTATCCTTTTTATGATTGGCTGTATAA
GGCACTCACCTTGCTTGTAATCGCTTGCCCTTGTGCGTTGGTTATTTCAACGCCTGTGACCGTAGTAAGTGGCTTGGCAG
CGGCAGCTCATCACGGACTTCTTATCAAGGGCGGAAGTTATTTAGAAATCGGCTATCAGTTAAAACTCATTGCGCTGGAT
AAAACGGGAACACTGACTGAAGGAAAGCCGGTGGTCACGGATTTTATTGCCTATGAAAGCACGCAAACCAAAGGTGATTT
ACTGCTCTTGGCAGCCAGTTTAGACAGTCACTCCGAACATCCTGTTGCCCACGCTTTGGTCGAATACTGGCGAGAAGAAC
AACCAACGGGGTCGTTATTGACGGTGAGTCGGTTTGAAGCAATTCCTGGTCGGGGCGTCATGGGGAGCGTCAATAATGAG
CAGTATTTTGTTGGGAATCATCAGCTGGCTGAAGACAATGGGGTGTGTAATTCCGGTATCGAAAAACAACTTGCTCAGTT
AGAGCAAGAAGGAAAGACCACAGTTATTTTAAGTAATGACACAACCGTGTTGGCTATTTTTGCAGTAGCGGATACCCTTC
GTTCAACCAGCCAATTAGCCATCCAATCCTTGCATCAACGTGGCATCAAAACAGCCATGTTAACTGGAGATAATGCCGTC
ACCGCTGCCGCTATTGCCAAAGAGGTGGGAATTGATGAAGTCAATGCCAATATCTTGCCTACAGAGAAGCTGAATGCCAT
GAACGCCCTGTTGGCTCATTACCACACCGTGGGTATGGTTGGTGATGGCATTAATGATGCCCCTGCACTTGCAAAGGCAA
CGATTAGTTTCGCGATGGGAAAAGGGACTGATACCGCACTTGAAACAGCGGATGTGGCCCTGATGAACGATAATTTAGCG
ATGCTGTCTTTTTTTATCGATTTAAGTCATAAAACAGCTCGGGTGCTACGTCAAAATATCAGTTTATCGATTGCTATCAA
GGTTGTTTTTTTCATCTTGGCTTTGGCTGGGTTGGCGACACTTTGGATGGCGGTTTTTGCCGATATGGGAGCAAGTCTCA
TTGTTGTTGCGAATGGTTTGCGATTGTTGAATTTTCAAAATAAAAACACCAGTTAA

Protein sequence :
MTTPLTLTTFFVAGLDCPAEEQLIRRQLQTIPEIEKMDFNFIAEEVTIHHRLNTIEPLQRQIEALGMSVRTKSSTKSDSP
KEANDFSWWWLAVAGLLALFSEVLSYLFGTEKSVWVAALALVAMAISGPPTFKKGWLALRTKALNINSLMMIAITGAILI
GEWPEAAMVTVLFALAERIERYSLDKARLAIRSLMQIAPDEATVKTTEGKWQKLAVENIKSGAIILVKPGERIALDGVIV
SGQSSVNQAPITGESMPVSKQTGDSVFAGTLNERGSFEVKVTKESGDTLLAKIGKAIEQAQAERAPTQRFVDEFAKYYTP
IMVLIAVAVALIPPIALGYPFYDWLYKALTLLVIACPCALVISTPVTVVSGLAAAAHHGLLIKGGSYLEIGYQLKLIALD
KTGTLTEGKPVVTDFIAYESTQTKGDLLLLAASLDSHSEHPVAHALVEYWREEQPTGSLLTVSRFEAIPGRGVMGSVNNE
QYFVGNHQLAEDNGVCNSGIEKQLAQLEQEGKTTVILSNDTTVLAIFAVADTLRSTSQLAIQSLHQRGIKTAMLTGDNAV
TAAAIAKEVGIDEVNANILPTEKLNAMNALLAHYHTVGMVGDGINDAPALAKATISFAMGKGTDTALETADVALMNDNLA
MLSFFIDLSHKTARVLRQNISLSIAIKVVFFILALAGLATLWMAVFADMGASLIVVANGLRLLNFQNKNTS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 9e-151 52
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 7e-115 48
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 2e-112 47
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-112 47

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_006506679.1 zinc, cobalt and lead efflux system BAC0298 Protein 7e-151 53
cadA YP_006506679.1 zinc, cobalt and lead efflux system BAC0461 Protein 2e-77 41