Gene Information

Name : pilR (LPO_1189)
Accession : YP_006505182.1
Strain : Legionella pneumophila Lorraine
Genome accession: NC_018139
Putative virulence/resistance : Virulence
Product : fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator ; sigma54 interaction protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1231377 - 1232705 bp
Length : 1329 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11243806, 21140164, 2666400, 89327164, 92255260, 94089392; Product type r : regulator

DNA sequence : 
ATGACCAAAAGTAAAGTGCTTGTTATAGATGACGAACCAGATATAAGAGAGTTATTAACTCTTACTTTATCACGTATGGG
TTTAACTTGCGATGCAGTGTCTGACTTTAAGCAAGGCATAGAACATATAAAACAAAATTATTATTCTTTGGTTTTAACCG
ATATGCGTTTACCTGATGGAGATGGTATAGAAATTGTTAAATTCATTCAGAAATACAAACCGCAGGTGCCAGTTGCCGTC
ATTACTGCCTATGGAAATGTCGAGGGTGCGGTCAACACTTTAAAGGCGGGTGCATTTGATTACGTATCAAAACCTATAGA
CTTAAAAATGCTTAGAGATCTCGTTAAGACGGCATTATCCATGCAAAACCCGCCTACCGAGAAGCCTGATGAAGGTCTAC
TGGTTGGTGAAAGTTTGGTAATGCAACAACTTCGTGAAAACATTCATAAATTAGCTCGCAGTCAGGCACCAGTTTTTATT
CAAGGAGCTTCAGGTGTTGGAAAAGAATTGGTCGCTCAGTTGATCCATGCTAATGGTCCCAGAAAGGATAAGCCATTTAT
TCCTGTAAACTGTGGCGCTATACCTGGTGAGTTGATGGAATCAGAGTTTTTTGGCCATAAAAAAGGGAGCTTTACAGGAG
CGATTTCTGATAAAACAGGGTTGTTTGTTGCGGCTCATGGTGGCACTTTGTTTCTTGATGAAATCGCCGAACTTCCTCTC
GCCATGCAGGTTAAATTGCTACGTGCCATTCAGGAGAAGGCAATTAAGCCGATAGGTGAGTTATATGAAGTTCCTGTGGA
TGTTCGCATCCTAAGTGCGAGTCATAAAAATTTGATTGAGGAAGTTAATGCAGGGGCGTTTCGTCAAGATTTGTATTATC
GAATTAATGTGATTGAATTGCGCGTCCCAACTTTAATGGAAAGGCTTTCAGATATTCCTTGCCTGACAGAGGCGATATTA
AGAAAGTTATCTAAAAATCAAAACAGAAACCTGGTGAAAATAAATCCATCCTGTTTTGAAATATTGAGTCGTTATCATTT
TCCAGGAAATGTCAGAGAACTGGAGAATATCCTCGAGCGTGCTATGGCTATGTGTGAAGGAGAGGTTATAGAACCATCCG
ATTTACATTTGCCAAGAACAACAATAACCCCAGCTGTTGCCGTACCCTCCACGTCAGCTAACTTAAATGGTTACCTTCAG
GATCAGGAAAAAGAGTTAATTCTTGATGCGCTTGAGAAAACAAAATGGAACAGAACCGCTGCTGCACAACTACTGGGGGT
CAGCTTCCGAACTCTCCGTTATCGATTAAAAAAACTGGGCCTTGATTAG

Protein sequence : 
MTKSKVLVIDDEPDIRELLTLTLSRMGLTCDAVSDFKQGIEHIKQNYYSLVLTDMRLPDGDGIEIVKFIQKYKPQVPVAV
ITAYGNVEGAVNTLKAGAFDYVSKPIDLKMLRDLVKTALSMQNPPTEKPDEGLLVGESLVMQQLRENIHKLARSQAPVFI
QGASGVGKELVAQLIHANGPRKDKPFIPVNCGAIPGELMESEFFGHKKGSFTGAISDKTGLFVAAHGGTLFLDEIAELPL
AMQVKLLRAIQEKAIKPIGELYEVPVDVRILSASHKNLIEEVNAGAFRQDLYYRINVIELRVPTLMERLSDIPCLTEAIL
RKLSKNQNRNLVKINPSCFEILSRYHFPGNVRELENILERAMAMCEGEVIEPSDLHLPRTTITPAVAVPSTSANLNGYLQ
DQEKELILDALEKTKWNRTAAAQLLGVSFRTLRYRLKKLGLD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00300 YP_008207765.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Not tested AbaR25 Protein 2e-97 49
BJAB0868_00304 YP_008211630.1 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Not tested AbaR26 Protein 2e-97 49

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pilR YP_006505182.1 fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator ; sigma54 interaction protein BAC0467 Protein 3e-78 42
pilR YP_006505182.1 fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator ; sigma54 interaction protein BAC0089 Protein 3e-71 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pilR YP_006505182.1 fused DNA-binding response regulator in two-component regulatory system with ZraS: response regulator ; sigma54 interaction protein VFG1214 Protein 9e-132 60